Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot study

Autor: Ying-Gang Zhu, Meng-meng Shi, Antoine Monsel, Cheng-xiang Dai, Xuan Dong, Hong Shen, Su-ke Li, Jing Chang, Cui-li Xu, Ping Li, Jing Wang, Mei-ping Shen, Cheng-jie Ren, De-chang Chen, Jie-Ming Qu

Publikováno v: Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-10 (2022)

Abstract Background Existing clinical studies supported the potential efficacy of mesenchymal stromal cells as well as derived exosomes in the treatment of COVID-19. We aimed to explore the safety and efficiency of aerosol inhalation of the exosomes

Externí odkaz: https://doaj.org/article/3f93988d34ce4945b9a87584a48c2074

Adipose-Derived Mesenchymal Stem Cells Ameliorating Pseudomonas aeruginosa–induced Acute Lung Infection via Inhibition of NLRC4 Inflammasome

Autor: Lu-lu Li, Ying-gang Zhu, Xin-ming Jia, Dong Liu, Jie-ming Qu

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)

BackgroundPseudomonas aeruginosa (PA) is one of the most common Gram-negative bacteria causing hospital-acquired pulmonary infection, with high drug resistance and mortality. Therefore, it is urgent to introduce new non-antibiotic treatment strategie

Externí odkaz: https://doaj.org/article/811ab0c363b04e9fb1c9df3bd46d8da1

Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy

Autor: Ying-Gang Zhu, Jie-Ming Qu, Jing Zhang, Hong-Ni Jiang, Jin-Fu Xu

Publikováno v: Mediators of Inflammation, Vol 2011 (2011)

Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), continue to be a major cause of morbidity and mortality in critically ill patients. The present therapeutic strategies for ALI/ARDS including supportive car

Externí odkaz: https://doaj.org/article/cb8a58b63ff64687a001ea6dd49b3526

Role of miR‐466 in mesenchymal stromal cell derived extracellular vesicles treating inoculation pneumonia caused by multidrug‐resistant Pseudomonas aeruginosa

Autor: Antoine Monsel, Jie-Ming Qu, Meng-Meng Shi, Jiayang Yan, Jean-Jacques Rouby, Ying-gang Zhu, Hanssa Dwarka Summah

Publikováno v: Clinical and Translational Medicine
Clinical and Translational Medicine, Heidelberg : Springer-Verlag, 2021, 11, pp.e287. ⟨10.1002/ctm2.287⟩
Clinical and Translational Medicine, 2021, 11, pp.e287. ⟨10.1002/ctm2.287⟩

Rationale The effects of mesenchymal stromal cells (MSCs) and MSC‐derived extracellular vesicles (MSC EVs) on multidrug‐resistant pseudomonas aeruginosa (MDR‐PA)‐induced pneumonia remain unclear. Materials and methods MicroRNA array and RT‐

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4685d43267154a2d6885938a117c05d
https://doi.org/10.1002/ctm2.287

Microbial Etiology and Prognostic Factors of Ventilator-associated Pneumonia: A Multicenter Retrospective Study in Shanghai

Autor: Ying-gang Zhu, Qijian Cheng, Zhaohui Rong, Jieming Qu, Guifang Wang, Yi Huang, Jin-Fu Xu, Yang Jiao, Jing Zhang, Jin Gong, Ping Li, Lin Song, Yi Li, Huayin Li, Shuo Sun, Shuo Liang, Zhijun Jie, Bin Liu

Publikováno v: Clinical Infectious Diseases. 67:S146-S152

Background The microbial etiology and mortality risk factors of ventilator-associated pneumonia (VAP) have not been investigated extensively in Shanghai. Methods VAP cases were identified from the patients hospitalized during the period from 1 Januar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d209eacaa59cc86042bec41a0d8f3e91
https://doi.org/10.1093/cid/ciy686