Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Ying-Chieh Sun"'
Autor:
Zheng-Kui Weng, Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Chih-Hsin Lin, Pei-Hsuan Tseng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen, Chiung-Mei Chen
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 219 (2023)
Misfolded aggregation of the hyperphosphorylated microtubule binding protein Tau in the brain is a pathological hallmark of Alzheimer’s disease (AD). Tau aggregation downregulates brain-derived neurotrophic factor (BDNF)/tropomycin receptor kinase
Externí odkaz:
https://doaj.org/article/9934b3950a89424da630b45ecdf060e8
Autor:
Ni-Ni Chiang, Te-Hsien Lin, Yu-Shan Teng, Ying-Chieh Sun, Kuo-Hsuan Chang, Chung-Yin Lin, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Chiung-Mei Chen, Guey-Jen Lee-Chen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with memory loss and cognitive decline. Neurofibrillary tangles (NFTs) formed by hyperphosphorylated Tau protein are one of the pathological hallmarks of several neurodegenerative
Externí odkaz:
https://doaj.org/article/903563a365794c9a87376fb3f6c6ad59
Autor:
Ching-Chia Huang, Kuo-Hsuan Chang, Ya-Jen Chiu, Yi-Ru Chen, Tsai-Hui Lung, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Ying-Chieh Sun, Chiung-Mei Chen, Wenwei Lin, Guey-Jen Lee-Chen
Publikováno v:
Cells, Vol 10, Iss 11, p 3095 (2021)
Alzheimer’s disease (AD) is a common neurodegenerative disease presenting with progressive memory and cognitive impairments. One of the pathogenic mechanisms of AD is attributed to the aggregation of misfolded amyloid β (Aβ), which induces neurot
Externí odkaz:
https://doaj.org/article/55f12e9aea6649f9b7d98415a9df3644
Autor:
Ya-Jen Chiu, Yu-Shan Teng, Chiung-Mei Chen, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Kuo-Hsuan Chang, Guey-Jen Lee-Chen
Publikováno v:
Biomolecules & Therapeutics. 31:285-297
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cc14cf41526fe1a53aac8b96e9b87e9
https://doi.org/10.4062/biomolther.2022.136
https://doi.org/10.4062/biomolther.2022.136
Autor:
Chih-Hsin, Lin, Yu-Shao, Hsieh, Ying-Chieh, Sun, Wun-Han, Huang, Shu-Ling, Chen, Zheng-Kui, Weng, Te-Hsien, Lin, Yih-Ru, Wu, Kuo-Hsuan, Chang, Hei-Jen, Huang, Guan-Chiun, Lee, Hsiu Mei, Hsieh-Li, Guey-Jen, Lee-Chen
Publikováno v:
Biomolecules & Therapeutics. 31:127-138
Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that implicates in multiple cellular processes and links with the neurodegenerative diseases including Alzheimer's disease (AD). In this study, structure-based virtual scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059f62d91b04ae14a0b5a4f6d01ff152
https://doi.org/10.4062/biomolther.2022.035
https://doi.org/10.4062/biomolther.2022.035
Autor:
Yi-Ching Wang, Hung-Chi Cheng, Wen-Shan Li, Tzu-Ting Chang, Gopula Balraj, Kuan-Wei Wu, Szu-Chi Wang, Ying-Chieh Sun, Li-Wha Wu, Hsueh-Fen Juan, Sin-Ming Huang, Yen-An Tang, Jia-Yang Chen
Supplementary Materials, Figures 1-7, Table 1 from A Novel Sialyltransferase Inhibitor Suppresses FAK/Paxillin Signaling and Cancer Angiogenesis and Metastasis Pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2a3bcd9bb54626152352c47c9c21fa
https://doi.org/10.1158/0008-5472.22385916
https://doi.org/10.1158/0008-5472.22385916
Publikováno v:
Physical Chemistry Chemical Physics. 22:4967-4973
Nowadays identifying a high-performance catalyst for converting methane to methanol is crucial because methanol serves as an excellent energy source and has wide chemical applications. In the present study, we used DFT, a computational chemistry meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ac5105c7073242701f09fc7adb42484
https://doi.org/10.1039/c9cp06002b
https://doi.org/10.1039/c9cp06002b
Autor:
Ya-Jen Chiu, Te-Hsien Lin, Kuo-Hsuan Chang, Wenwei Lin, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Chiung-Mei Chen, Ying-Chieh Sun, Guey-Jen Lee-Chen
Publikováno v:
Aging. 14(18)
Decreased BDNF and impaired TRKB signaling contribute to neurodegeneration in Alzheimer's disease (AD). We have shown previously that coumarin derivative LM-031 enhanced CREB/BDNF/BCL2 pathway. In this study we explored if LM-031 analogs LMDS-1 to -4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b2d49adbac1a8e63d1c9edd06edde4
https://pubmed.ncbi.nlm.nih.gov/36170028
https://pubmed.ncbi.nlm.nih.gov/36170028
Autor:
Chiung Mei Chen, Yi Ru Chen, Hsiu Mei Hsieh-Li, Ming Tsan Su, Ching Chia Huang, Ying Chieh Sun, Kuo-Hsuan Chang, Guey Jen Lee-Chen, Ya Jen Chiu, Tsai Hui Lung, Wenwei Lin
Publikováno v:
Cells
Cells, Vol 10, Iss 3095, p 3095 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 3095, p 3095 (2021)
Volume 10
Issue 11
Alzheimer’s disease (AD) is a common neurodegenerative disease presenting with progressive memory and cognitive impairments. One of the pathogenic mechanisms of AD is attributed to the aggregation of misfolded amyloid β (Aβ), which induces neurot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db79c67896b5992edb9855ee5432a7ce
https://pubmed.ncbi.nlm.nih.gov/34831318
https://pubmed.ncbi.nlm.nih.gov/34831318
Autor:
Guey Jen Lee-Chen, Ying Chieh Sun, Yu Hsuan Hsieh, Ya Jen Chiu, Te Hsien Lin, Chiung Mei Chen, Kuo-Hsuan Chang, Guan Chiun Lee, Hsiu Mei Hsieh-Li
Publikováno v:
Neurochemistry International. 125:175-186
The pathogenesis of Alzheimer's disease (AD) is involved in the aggregation of misfolded amyloid β (Aβ), which upregulates the activity of acetylcholinesterase (AChE), increases the production of reactive oxygen species (ROS), enhances neuroinflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d16e478a0efff8236768990e6df243
https://doi.org/10.1016/j.neuint.2019.01.021
https://doi.org/10.1016/j.neuint.2019.01.021