Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ying-Chao Duan"'
Autor:
Yi-Chao Zheng, Long-Zhen Wang, Li-Jie Zhao, Li-Juan Zhao, Qian-Na Zhan, Jin-Lian Ma, Bin Zhang, Meng-Meng Wang, Zhi-Ru Wang, Jin-Feng Li, Ying Liu, Zhe-Sheng Chen, Dan-Dan Shen, Xue-Qi Liu, Meng Ren, Wen-Lei Lv, Wen Zhao, Ying-Chao Duan, Hong-Min Liu
Publikováno v:
Cellular Physiology and Biochemistry, Vol 38, Iss 1, Pp 185-193 (2016)
Background/Aims: Human SIRT1 is reported to be involved in tumorgenesis, mainly due to its modulating effect on p53 by deacetylation on lysine382. A large quantity of SIRT1 inhibitors was applied in chemotherapeutic study, but few of them were applie
Externí odkaz:
https://doaj.org/article/b5950129454c4ef5b1fd2a5ca7ffddfa
Autor:
Ming‐Ti Lv, He‐Cheng Wang, Xiao‐Wen Meng, Ya‐Ting Shi, Yi‐Min Zhang, Lin‐Lin Shan, Ru‐Ling Shi, Tian‐Jun Ni, Ying‐Chao Duan, Zhi‐Jun Yang, Wei Zhang
Publikováno v:
CNS Neuroscience & Therapeutics.
Autor:
Meiting Wang, Zongya Zhao, Chang Wang, Yi Yu, Yunlong Gao, Min Yang, Ziqing Wu, Ying-Chao Duan, Junqiang Zhao, Yongtao Xu, Jiarui Lu, Di Han, Qinghe Gao
Publikováno v:
Future Medicinal Chemistry. 13:1415-1433
Background: Overexpression of LSD1 is associated with the occurrence of many diseases, including cancers, which makes LSD1 a significant target for anticancer drug research. Methodology & Results: With the aid of 3D quantitative structure–activity
Autor:
Yuan Zhao, Yuan-Yuan Guan, Fang Zhao, Tong Yu, Shao-Jie Zhang, Yi-Zhe Zhang, Ying-Chao Duan, Xiao-Li Zhou
Publikováno v:
European journal of medicinal chemistry. 231
The polycomb repressive complex 2 (PRC2), which comprised of the core subunits: Enhancer of Zeste Homolog 2 (EZH2), Suppressor of Zeste 12 (SUZ12), and Embryonic Ectoderm Development (EED), is an essential epigenetic gene silencer responsible for dep
Autor:
Xiao-Li, Zhou, Fang, Zhao, Yong-Tao, Xu, Yuan-Yuan, Guan, Tong, Yu, Yi-Zhe, Zhang, Ying-Chao, Duan, Yuan, Zhao
Publikováno v:
Bioorganic & Medicinal Chemistry. 73:117033
Targeted protein degradation using proteolysis-targeting chimeras (PROTACs) has emerged as an effective strategy for drug discovery, given their unique advantages over target protein inhibition. The bromodomain and extra-terminal (BET) family protein
Autor:
Ying-Chao Duan, Hong-Min Liu, Yi-Chao Zheng, Xiaoyu Zhai, Xiaojuan Wang, Qin Wenping, Yuan-Yuan Guan, Feng-Zhi Suo
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:6000-6014
LSD1 is implicated in a number of malignancies and has emerged as an exciting target. As part of our sustained efforts to develop novel reversible LSD1 inhibitors for epigenetic therapy of cancers, in this study, we reported a series of stilbene deri
Autor:
Ying-Chao Duan, Yongtao Xu, Zongya Zhao, Songjie Zhang, Min Yang, Junqiang Zhao, Yi-Chao Zheng, Zihao He, Qinghe Gao, Chang Wang, Xiaoyuan Lu, Yunlong Gao, Meiting Wang, Lin-Feng Jin
Publikováno v:
Molecules
Volume 24
Issue 24
Volume 24
Issue 24
Overexpression of lysine specific demethylase 1 (LSD1) has been found in many cancers. New anticancer drugs targeting LSD1 have been designed. The research on irreversible LSD1 inhibitors has entered the clinical stage, while the research on reversib
Autor:
Ying-Chao Duan, Yi-Chao Zheng, Chao-Ya Ma, Yong-Cheng Ma, Xiaoyu Zhai, Lina Ding, Qin Wenping, Ying-Li Zhu, Yuan-Yuan Guan, Jing Yang
Publikováno v:
European Journal of Medicinal Chemistry. 140:392-402
Lysine specific demethylase 1 (LSD1) and Histone deacetylases (HDACs) are promising drug targets for cancers. Recent studies reveal an important functional interplay between LSD1 and HDACs, and there is evidence for the synergistic effect of combined
Autor:
Lin-Feng Jin, Tong Yu, Ying-Chao Duan, Xiao-Jing Shi, Yu Song, Yuan-Yuan Guan, Shao-Jie Zhang
Publikováno v:
European Journal of Medicinal Chemistry. 222:113588
Abnormal epigenetics is a critical hallmark of human cancers. Anticancer drug discovery directed at histone epigenetic modulators has gained impressive advances with six drugs available for cancer therapy and numerous other candidates undergoing clin
Autor:
Ying-Chao Duan, Yuan-Yuan Guan, Hong-Min Liu, Yi-Chao Zheng, Xu-Dong Sun, Xiaoyu Zhai, Qin Wenping, Dan-Dan Shen, Xue-Qi Liu, Lina Ding
Publikováno v:
European Journal of Medicinal Chemistry. 126:246-258
Inhibition of lysine-specific demethylase 1 (LSD1) has recently emerged as an attractive therapeutic target for treating cancer and other diseases. As a continuity of our ongoing effort to identify novel small-molecule LSD1-inhibitors, we designed an