Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Ying Xim, Tan"'
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Akademický článek
Small molecule inhibition of Csk alters affinity recognition by T cells
Autor: Boryana N Manz, Ying Xim Tan, Adam H Courtney, Florentine Rutaganira, Ed Palmer, Kevan M Shokat, Arthur Weiss
Publikováno v: eLife, Vol 4 (2015)
The C-terminal Src kinase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in controlling basal and inducible receptor signaling. To investigate how Csk activity regulates T cell antigen receptor (TCR) signaling
Externí odkaz: https://doaj.org/article/e6653f63875c4a5a97e6f38492b929c7
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6
Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling
Autor: Kevan M. Shokat, Tanya S. Freedman, Arthur Weiss, Boryana N. Manz, Chao Zhang, Ying Xim Tan
Publikováno v: Nature Immunology. 15:186-194
Signaling via the T cell antigen receptor (TCR) is initiated by Src-family kinases (SFKs). To understand how the kinase Csk, a negative regulator of SFKs, controls the basal state and the initiation of TCR signaling, we generated mice that express a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22a1636ae4cff911d2ac8e215a0a9515
https://doi.org/10.1038/ni.2772
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7
Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance
Autor: Mina J. Bissell, Mikala Egeblad, Miriam R. Fein, Eirik Frengen, Jae-Hyun Park, Jing Qiu, Zena Werb, Hanne A. Askautrud, Vicki Plaks, Pranay Sinha, Elizabeth S. Nakasone, Juwon Park, Morten Grønbech Rasch, Ying Xim Tan, Tim Kees, Andrew J. Ewald
Publikováno v: Cancer Cell. 21:488-503
SummaryLittle is known about the dynamics of cancer cell death in response to therapy in the tumor microenvironment. Intravital microscopy of chemotherapy-treated mouse mammary carcinomas allowed us to follow drug distribution, cell death, and tumor-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daeb7e39ef9d478318b5400544e3b28e
https://doi.org/10.1016/j.ccr.2012.02.017
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8
The role of PRDMs in cancer: one family, two sides
Autor: Slim Mzoughi, Ying Xim Tan, Ernesto Guccione, Diana Low
Publikováno v: Current opinion in geneticsdevelopment. 36
The PRDM family of proteins share a unique structure, with an N-terminal PR domain, which has a potential methyltransferase activity, followed by a distinct number of zinc fingers at the C-terminus, potentially mediating protein-protein, protein-RNA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44380a7e374dad9f38ea650d8c08aa9a
https://pubmed.ncbi.nlm.nih.gov/27153352
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9
Small molecule inhibition of Csk alters affinity recognition by T cells
Autor: Boryana N. Manz, Ed Palmer, Kevan M. Shokat, Arthur Weiss, Adam H. Courtney, Ying Xim Tan, Florentine U. Rutaganira
Publikováno v: eLife, vol 4, iss AUGUST2015
Manz, BN; Tan, YX; Courtney, AH; Rutaganira, F; Palmer, E; Shokat, KM; et al.(2015). Small molecule inhibition of Csk alters affinity recognition by T cells. eLife, 4(AUGUST2015). doi: 10.7554/eLife.08088. UCSF: Retrieved from: http://www.escholarship.org/uc/item/95p5m15s
eLife
eLife, Vol 4 (2015)
The C-terminal Src kinase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in controlling basal and inducible receptor signaling. To investigate how Csk activity regulates T cell antigen receptor (TCR) signaling
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5849a45ee081fe8e947fa12d4548ccd4
https://escholarship.org/uc/item/95p5m15s
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