Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Ying Xian Pan"'
Autor:
Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Publikováno v:
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://doaj.org/article/dc31183697a3454e95268139bbe3d9fd
Autor:
Shan Liu, Wen-Jia Kang, Anna Abrimian, Jin Xu, Luca Cartegni, Susruta Majumdar, Patrick Hesketh, Alex Bekker, Ying-Xian Pan
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1525 (2021)
Most opioid analgesics used clinically, including morphine and fentanyl, as well as the recreational drug heroin, act primarily through the mu opioid receptor, a class A Rhodopsin-like G protein-coupled receptor (GPCR). The single-copy mu opioid rece
Externí odkaz:
https://doaj.org/article/8fc2fb547d2a4b66bb43e4e59c47db7e
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3779 (2021)
There exist three main types of endogenous opioid peptides, enkephalins, dynorphins and β-endorphin, all of which are derived from their precursors. These endogenous opioid peptides act through opioid receptors, including mu opioid receptor (MOR), d
Externí odkaz:
https://doaj.org/article/ae19a461e45943d5ac9248d8e46db19f
Autor:
Bronwyn M. Kivell, Shainnel O. Eans, Abdullah Allaoa, András Váradi, Lisa L. Wilson, Gavril W. Pasternak, Rajendra Uprety, Andrew C. Kruegel, John E. Pintar, Xiaohai Li, Samuel T. Slocum, Takeshi Irie, Jay P. McLaughlin, Brittany Scouller, Amy F. Alder, Michael D. Cameron, Sanjay Kalra, Ying-Xian Pan, Amanda Hunkele, Susruta Majumdar, Michael Ansonoff, Valerie Le Rouzic, Dalibor Sames, Soumen Chakraborty, Jin Xu
Publikováno v:
J Med Chem
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacolo
Autor:
Abdelfattah Faouzi, Haoqing Wang, Saheem A. Zaidi, Jeffrey F. DiBerto, Tao Che, Qianhui Qu, Michael J. Robertson, Manish K. Madasu, Amal El Daibani, Balazs R. Varga, Tiffany Zhang, Claudia Ruiz, Shan Liu, Jin Xu, Kevin Appourchaux, Samuel T. Slocum, Shainnel O. Eans, Michael D. Cameron, Ream Al-Hasani, Ying Xian Pan, Bryan L. Roth, Jay P. McLaughlin, Georgios Skiniotis, Vsevolod Katritch, Brian K. Kobilka, Susruta Majumdar
Publikováno v:
Nature.
Mu opioid receptor (µOR) agonists like fentanyl have long been used for pain management, but are considered a major public health concern due to their adverse side effects, including lethal overdose.
Autor:
Gavril W. Pasternak, Rahul Jilakara, Ying Xian Pan, Rajendra Uprety, Amanda Hunkele, Kevin Appourchaux, Tao Che, Amal El Daibani, Shainnel O. Eans, Jay P. McLaughlin, Lisa Thammavong, Soumen Chakraborty, Susruta Majumdar, Valerie Le Rouzic, Nitin Nuthikattu
Publikováno v:
ACS Chem Neurosci
Dry leaves of kratom (mitragyna speciosa) are anecdotally consumed as pain relievers and antidotes against opioid withdrawal and alcohol use disorders. There are at least 54 alkaloids in kratom; however, investigations to date have focused around mit
Autor:
Bing Xie, Valerie P. Le Rouzic, Alexander Goldberg, Meng-Hua M. Tsai, Li Chen, Tiffany Zhang, Antara Sinha, Ying-Xian Pan, Michael H. Baumann, Lei Shi
Publikováno v:
Neuropharmacology. 227:109442
Publikováno v:
Cellular and Molecular Neurobiology. 41:827-834
This special issue is a tribute to our mentor, colleague and friend, Gavril W. Pasternak, MD, PhD. Homage to the breadth and depth of his work (~ 450 publications) over a 40 career in pharmacology and medicine cannot be captured fully in one special
Autor:
Abdelfattah Faouzi, Hye Jean Yoon, Rajendra Uprety, John M. Streicher, Lakshmi A. Devi, Susruta Majumdar, Michael Ansonoff, Ivone Gomes, Nicolas Massaly, Tiffany Zhang, Valerie Le Rouzic, Attila Keresztes, Jose A. Morón, Ying-Xian Pan, Achla Gupta, Abdullah Allaoa, John E. Pintar
Publikováno v:
J Med Chem
In this work, we studied a series of carfentanyl amide-based opioid derivatives targeting the mu opioid receptor (μOR) and the delta opioid receptor (δOR) heteromer as a credible novel target in pain management therapy. We identified a lead compoun