Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ying Wai Chan"'
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114464- (2024)
Summary: Poly(ADP-ribose) polymerase inhibitors (PARPis) exhibit remarkable anticancer activity in tumors with homologous recombination (HR) gene mutations. However, the role of other DNA repair proteins in PARPi-induced lethality remains elusive. He
Externí odkaz:
https://doaj.org/article/5fc4722e8f114fa48904e18ea5cc55c5
Autor:
Wensheng Li, Cheng Ye, Mulan He, Wendy K. W. Ko, Christopher H. K. Cheng, Ying Wai Chan, Anderson O. L. Wong
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Gonadotropin-releasing hormone (GnRH) is a key stimulator for gonadotropin secretion in the pituitary and its pivotal role in reproduction is well conserved in vertebrates. In fish models, GnRH can also induce prolactin (PRL) release, but little is k
Externí odkaz:
https://doaj.org/article/9f17177a31ff499daab387e3462ffffd
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Adiponectin (AdipoQ) is an adipokine involved in glucose homeostasis and lipid metabolism. In mammals, its role in appetite control is highly controversial. To shed light on the comparative aspects of AdipoQ in lower vertebrates, goldfish was used as
Externí odkaz:
https://doaj.org/article/c2763199f92c42379bff062edcbb5a5e
Publikováno v:
Advanced Science, Vol 10, Iss 12, Pp n/a-n/a (2023)
Abstract Chromatin bridges connecting the two segregating daughter nuclei arise from chromosome fusion or unresolved interchromosomal linkage. Persistent chromatin bridges are trapped in the cleavage plane, triggering cytokinesis delay. The trapped b
Externí odkaz:
https://doaj.org/article/4a6a62f33f6e43678106948dfb8cc769
Autor:
Anaid Benitez, Marie Sebald, Radhakrishnan Kanagaraj, Monica C. Rodrigo-Brenni, Ying Wai Chan, Chih-Chao Liang, Stephen C. West
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112062- (2023)
Summary: Our genomes harbor conserved DNA sequences, known as common fragile sites (CFSs), that are difficult to replicate and correspond to regions of genome instability. Following replication stress, CFS loci give rise to breaks or gaps (termed CFS
Externí odkaz:
https://doaj.org/article/5ee6d94af6324807961f58a87846f6c4
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112032- (2023)
Summary: Resolution of ultrafine anaphase bridges (UFBs) must be completed before cytokinesis to ensure sister-chromatid disjunction. RIF1 is involved in UFB resolution by a mechanism that is not yet clear. Here, we show that RIF1 functions in mitosi
Externí odkaz:
https://doaj.org/article/040031e8f6d84b76bd6203c7ef65777b
Autor:
Wensheng Li, Cheng Ye, Mulan He, Ko, Wendy K. W., Cheng, Christopher H. K., Ying Wai Chan, Wong, Anderson O. L.
Publikováno v:
Frontiers in Endocrinology; 2024, p1-24, 24p
Autor:
Ying Wai Chan, Primrose Chanboonyasitt
Publikováno v:
Cell Cycle
article-version (VoR) Version of Record
article-version (VoR) Version of Record
To ensure genome stability, chromosomes need to undergo proper condensation into two linked sister chromatids from prophase to prometaphase, followed by equal segregation at anaphase. Emerging evidence has shown that persistent DNA entanglements conn
Autor:
Nannan Kong, Ying Wai Chan
Publikováno v:
STAR Protocols. 4:102286
Autor:
Stephen C. West, Ying Wai Chan
Publikováno v:
Cell Cycle
Ultrafine anaphase bridges (UFBs) are a potential source of genome instability that is a hallmark of cancer. UFBs can arise from DNA catenanes at centromeres/rDNA loci, late replication intermediates induced by replication stress, and DNA linkages at