Výsledky vyhledávání

Spontaneous γH2AX Foci in Human Solid Tumor-Derived Cell Lines in Relation to p21WAF1 and WIP1 Expression

Autor: Bonnie Andrais, David Murray, Razmik Mirzayans, Ying W Wang, Robert H. Weiss, April Scott

Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 5, Pp 11609-11628 (2015)
International journal of molecular sciences, vol 16, iss 5
International Journal of Molecular Sciences
Volume 16
Issue 5
Pages 11609-11628

Phosphorylation of H2AX on Ser139 (γH2AX) after exposure to ionizing radiation produces nuclear foci that are detectable by immunofluorescence microscopy. These so-called γH2AX foci have been adopted as quantitative markers for DNA double-strand br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbb26043c2b0f1a3909e6c2e849d95e
http://www.mdpi.com/1422-0067/16/5/11609

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Multinucleated Giant Cancer Cells Produced in Response to Ionizing Radiation Retain Viability and Replicate Their Genome

Autor: David Murray, Bonnie Andrais, April Scott, Piyush Kumar, Razmik Mirzayans, Ying W Wang

Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 2, p 360 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 2; Pages: 360
International Journal of Molecular Sciences

Loss of wild-type p53 function is widely accepted to be permissive for the development of multinucleated giant cells. However, whether therapy-induced multinucleation is associated with cancer cell death or survival remains controversial. Herein, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acc02cc72c3945fe588c6188e1ec184
http://www.mdpi.com/1422-0067/18/2/360

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Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status

Autor: David Murray, Razmik Mirzayans, Ying W Wang, Bonnie Andrais, April Scott

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 14, Iss 11, Pp 22409-22435 (2013)

Ionizing radiation triggers diverse responses in human cells encompassing apoptosis, necrosis, stress-induced premature senescence (SIPS), autophagy, and endopolyploidy (e.g., multinucleation). Most of these responses result in loss of colony-forming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060049e0de6c134ba8b68184b6bd73b4
http://europepmc.org/articles/PMC3856071

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Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells

Autor: Minna Woo, Gary M. Pigeau, Jelena Kolic, Michael B. Hoppa, Ying W. Wang, Patrick E. MacDonald, Thomas Rückle, Jocelyn E. Manning Fox, Brandon J. Ball

Publikováno v: Diabetes

OBJECTIVE Phosphatidylinositol 3-OH kinase (PI3K) has a long-recognized role in β-cell mass regulation and gene transcription and is implicated in the modulation of insulin secretion. The role of nontyrosine kinase receptor–activated PI3K isoforms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9037d1f251c2b3fd5aecd3bd02688e05
https://doi.org/10.2337/db08-1371

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