Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ying Shuan Lee"'
Autor:
Wei-Chun Huang, Li-Juan Huang, Liang-Sheng Hsu, Shih-Ting Huang, Wen-Ting Lo, Tzu-Fan Wang, Wei-Ting Sun, Win-Yin Wei, Ying-Shuan Lee, Shih-Hsien Chuang, Chao-Pin Lee, Ho-Hsuan Chou, Shu-Hui Chen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The site selectivity for lysine conjugation on a native protein is difficult to control and characterize. Here, we applied mass spectrometry to examine the conjugation kinetics of Trastuzumab-IgG (Her-IgG) and α-lactalbumin under excess lin
Externí odkaz:
https://doaj.org/article/ae57a14857544249a44e7cc16ab89855
Autor:
Johnson Y.N. Lau, Her-Sheng Lin, Chia-Wei Liu, Pei-Yi Tsai, Gillian M.G. Lau, Kuo-Jang Kao, Shih-Hsien Chuang, Jiann-Jyh Huang, Jia-Ming Chang, Ying-Shuan Lee, Chia-Chi Chang, Lynn Y.L. Huang
Current cytotoxic chemotherapy produces clinical benefit in patients with breast cancer but the survival impact is modest. To explore novel cytotoxic agents for the treatment of advanced disease, we have characterized a new and pharmacokinetically im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3a1cce64a84b11cad22e18b8aee0b62
https://doi.org/10.1158/1535-7163.c.6536740.v1
https://doi.org/10.1158/1535-7163.c.6536740.v1
Autor:
Johnson Y.N. Lau, Her-Sheng Lin, Chia-Wei Liu, Pei-Yi Tsai, Gillian M.G. Lau, Kuo-Jang Kao, Shih-Hsien Chuang, Jiann-Jyh Huang, Jia-Ming Chang, Ying-Shuan Lee, Chia-Chi Chang, Lynn Y.L. Huang
PDF - 126K, Includes the methods for preparation of TAI-95, drug-drug synergy experiments, and preliminary subacute toxicology, Table S1: Combination index of TAI-95 with anticancer agents, and supplementary figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cd2d4da138a03a29f6a3af653804d2
https://doi.org/10.1158/1535-7163.22501294
https://doi.org/10.1158/1535-7163.22501294
Autor:
Liang Sheng Hsu, Wei Chun Huang, Ying Shuan Lee, Shu Hui Chen, Wen Ting Lo, Shih Ting Huang, Win Yin Wei, Tzu Fan Wang, Shih Hsien Chuang, Wei Ting Sun, Ho Hsuan Chou, Chao Pin Lee, Li Juan Huang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
The site selectivity for lysine conjugation on a native protein is difficult to control and characterize. Here, we applied mass spectrometry to examine the conjugation kinetics of Trastuzumab-IgG (Her-IgG) and α-lactalbumin under excess linker conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67509fc182a9f0548cde9e7ab56824cb
https://doaj.org/article/ae57a14857544249a44e7cc16ab89855
https://doaj.org/article/ae57a14857544249a44e7cc16ab89855
Autor:
Lynn Y. L. Huang1 lynnhuang.lh245@gmail.com, Ying-Shuan Lee2 yslee@dcb.org.tw, Jiann-Jyh Huang2 lukehuang@mail.ncyu.edu.tw, Chia-chi Chang1 chichang@taivex.com, Jia-Ming Chang2 jiaming@dcb.org.tw, Shih-Hsien Chuang2 Shchuang51@mail.dcb.org.tw, Kuo-Jang Kao1 kuojang.kao@gmail.com, Yung-Jen Tsai2 yungjentsai@dcb.org.tw, Pei-Yi Tsai2 pytsai@dcb.org.tw, Chia-Wei Liu2 chiawei@dcb.org.tw, Her-Sheng Lin2 sheng@dcb.org.tw, Lau, Johnson Y. N.1 JohnsonYNLau@aol.com
Publikováno v:
Journal of Experimental & Clinical Cancer Research (17569966). 2014, Vol. 33 Issue 1, p1-31. 30p.
Autor:
Chia-chi Chang, Jiann-Jyh Huang, Ying-Shuan Lee, Gillian M.G. Lau, Johnson Y.N. Lau, Her-Sheng Lin, Lynn Y L Huang, Robert G. Gish, Kuo-Jang Kao, Jia-Ming Chang, Shih-Hsien Chuang, Chia-Wei Liu, Pei-Yi Tsai
Publikováno v:
Cancer Chemotherapy and Pharmacology. 74:511-520
Highly expressed in cancer protein 1 (Hec1) is an oncogene and a promising molecular target for novel anticancer drugs. The purpose of this study was to evaluate the potential of a Hec1 inhibitor, TAI-95, as a treatment for primary liver cancer.In vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc93731eed61d9178891ac831dc33e6
https://doi.org/10.1007/s00280-014-2540-7
https://doi.org/10.1007/s00280-014-2540-7
Autor:
Chao-Pin Lee, Shih-Hsien Chuang, Chuan-Lung Hsu, Chia-Cheng Wu, Wei-Ting Sun, Ying-Shuan Lee, Yu-Chin Nieh, Yi-Jen Chen, Wei Win-Yin
Publikováno v:
Cancer Research. 78:813-813
Globo H antigen is a hexasaccharide originally isolated as a ceramide-linked glycolipid from the human breast cancer cell line MCF-7. Globo H is also highly expressed in many other cancers such as colon cancer, ovarian cancer, gastric cancer, pancrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eced47ce1fbb039f99f60d1626989bb6
https://doi.org/10.1158/1538-7445.am2018-813
https://doi.org/10.1158/1538-7445.am2018-813
Autor:
Yu-Wen Tseng, Yann-Yu Lu, Mann-Yan Kuo, Chu-Bin Liao, Shian-Yi Chiou, Chia Wei Liu, Ying-Shuan Lee, Her Sheng Lin, Shao-Zheng Pen, Win Yin Wei
Publikováno v:
Cancer Research. 77:134-134
The Hedgehog (Hh) signaling pathway is a critical regulator of embryonic patterning, and aberrant Hh pathway activation has been implicated in a diverse spectrum of cancers. Therefore, components of the Shh pathway (such as Shh, SMO, and GLI1/2) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fb69950bd82bcd2bf8c8a8a6745e183
https://doi.org/10.1158/1538-7445.am2017-134
https://doi.org/10.1158/1538-7445.am2017-134
Autor:
Chia-Wei Liu, Jia-Ming Chang, Jiann-Jyh Huang, Lynn Y L Huang, Shih-Hsien Chuang, Chia-chi Chang, Johnson Y.N. Lau, Pei-Yi Tsai, Kuo-Jang Kao, Her-Sheng Lin, Ying-Shuan Lee, Gillian M.G. Lau
Publikováno v:
Molecular cancer therapeutics. 13(6)
Current cytotoxic chemotherapy produces clinical benefit in patients with breast cancer but the survival impact is modest. To explore novel cytotoxic agents for the treatment of advanced disease, we have characterized a new and pharmacokinetically im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b158f2339e737f64dd68bcab189d5e69
https://pubmed.ncbi.nlm.nih.gov/24694948
https://pubmed.ncbi.nlm.nih.gov/24694948
Autor:
Jiann-Jyh Huang, Jia-Ming Chang, Her-Sheng Lin, Yung-Jen Tsai, Pei-Yi Tsai, Ying-Shuan Lee, Chia-Wei Liu, Chia-chi Chang, Kuo-Jang Kao, Shih-Hsien Chuang, Lynn Y L Huang, Johnson Y.N. Lau
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Hec1 (NDC80) is an integral part of the kinetochore and is overexpressed in a variety of human cancers, making it an attractive molecular target for the design of novel anticancer therapeutics. A highly potent first-in-class compound targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed010dae9a4854ed80a5ba1a6f98bc12
https://doi.org/10.1186/1756-9966-33-6
https://doi.org/10.1186/1756-9966-33-6