Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice

Autor: Tulika Arora, Udo Wegmann, Anup Bobhate, Ying Shiuan Lee, Thomas U. Greiner, Daniel J. Drucker, Arjan Narbad, Fredrik Bäckhed

Publikováno v: Molecular Metabolism, Vol 5, Iss 8, Pp 725-730 (2016)

Objective: The enteroendocrine hormone glucagon-like peptide 1 (GLP-1) is an attractive anti-diabetic therapy. Here, we generated a recombinant Lactococcus lactis strain genetically modified to produce GLP-1 and investigated its ability to improve gl

Externí odkaz: https://doaj.org/article/b048ec4f1b7d4a9d9cb7601cb75249e3

The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism

Autor: Christina N. Heiss, Randy J. Seeley, Ying Shiuan Lee, Fredrik Bäckhed, Anna Håkansson Gladh, Daniel J. Drucker, Louise Mannerås-Holm, Julia Serrano-Lobo, Louise E. Olofsson

Publikováno v: Heiss, C N, Mannerås-Holm, L, Lee, Y S, Serrano-Lobo, J, Håkansson Gladh, A, Seeley, R J, Drucker, D J, Bäckhed, F & Olofsson, L E 2021, ' The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism ', Cell Reports, vol. 35, no. 8, 109163 . https://doi.org/10.1016/j.celrep.2021.109163

Mice lacking a microbiota are protected from diet-induced obesity. Previous studies have shown that feeding a Western diet causes hypothalamic inflammation, which in turn can lead to leptin resistance and weight gain. Here, we show that wild-type (WT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1246c48efc4ba88cddca0f7c9a69b5f7
https://doi.org/10.1016/j.celrep.2021.109163

Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production

Autor: Fredrik Bäckhed, Valentina Tremaroli, Anita Wichmann, Filipe De Vadder, Gilles Mithieux, Ying Shiuan Lee

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 5, Iss 4, Pp 263-270 (2016)

Objective Insulin-like peptide 5 (INSL5) is a recently identified gut hormone that is produced predominantly by L-cells in the colon, but its function is unclear. We have previously shown that colonic expression of the gene for the L-cell hormone GLP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa80bf3d7320546daa5775c5407c7a9c
https://doi.org/10.1016/j.molmet.2016.01.007

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

Autor: Ruth E. Ley, Erik Larsson, Omry Koren, Intawat Nookaew, Jens Nielsen, Fredrik Bäckhed, Valentina Tremaroli, Ashwana D. Fricker, Ying Shiuan Lee

Publikováno v: Gut

Background The gut microbiota has profound effects on host physiology but local hostemicrobial interactions in the gut are only poorly characterised and are likely to vary from the sparsely colonised duodenum to the densely colonised colon. Microorga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0610543c213b68bde1c11753210991c
https://doi.org/10.1136/gutjnl-2011-301104

Evaluation of meisoindigo, an indirubin derivative: in vitro antileukemic activity and in vivo pharmacokinetics

Autor: Meng Huang, Paul C. Ho, Hai-Shu Lin, Ying Shiuan Lee

Publikováno v: International journal of oncology. 45(4)

Meisoindigo has been a routine therapeutic agent in the clinical treatment of chronic myelogenous leukemia (CML) in China since the 1980s. In the present study, the in vitro antileukemic activity of meisoindigo was investigated in acute promyelocytic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68816063af8a9f6edc2eaab015eb64a9
https://pubmed.ncbi.nlm.nih.gov/25050545