Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Ying Shan Han"'
Autor:
Mark A. Wainberg, Ying-Shan Han
Publikováno v:
Journal of Virus Eradication, Vol 1, Iss 1, Pp 13-16 (2015)
Integrase strand transfer inhibitors (INSTIs) are the latest class of potent anti-HIV drugs. Currently, three INSTIs have been approved by the US Food and Drug Administration: raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG). Resistance m
Externí odkaz:
https://doaj.org/article/f38777e814404a9cac2a4f453dfe5cbb
Publikováno v:
Chemistrybiodiversity. 19(10)
Investigations on the twigs and leaves of Antirhea chinensis have led to the discovery of two undescribed pentacyclic triterpenoids (1 and 2) and nine known analogs. Compounds 1 and 2, each assigned as the ursane and 24-noroleanane-type triterpenoids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4027de23fae9a6f9965c0320fb6cb1c
https://pubmed.ncbi.nlm.nih.gov/36008326
https://pubmed.ncbi.nlm.nih.gov/36008326
Publikováno v:
Journal of Natural Products. 83:2416-2424
An ethanol extract of the powdered twigs of Podocarpus imbricatus afforded 14 new diterpenoids (1–14), which all share an aromatized C ring. These isolates belong to five diterpenoid types that inc...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffe8e11f634eeabe9b4e06b4ca00f852
https://doi.org/10.1021/acs.jnatprod.0c00291
https://doi.org/10.1021/acs.jnatprod.0c00291
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128310 (2015)
Understanding the HIV integrase protein and mechanisms of resistance to HIV integrase inhibitors is complicated by the lack of a full length HIV integrase crystal structure. Moreover, a lentiviral integrase structure with co-crystallised DNA has not
Externí odkaz:
https://doaj.org/article/d251431c5d4b4d68bddc6b3ba8585b8f
Publikováno v:
Journal of natural products. 83(8)
An ethanol extract of the powdered twigs of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2badd58fb58e6fcd0801c6bd35b7b263
https://pubmed.ncbi.nlm.nih.gov/32786878
https://pubmed.ncbi.nlm.nih.gov/32786878
Autor:
Ying-Shan Han, Thibault Mesplède
Publikováno v:
Expert Opinion on Investigational Drugs. 27:951-962
The Zika virus (ZIKV) infection results in severe neurological complications and has emerged as a threat to public health worldwide. No drugs or vaccines are available for use in the clinic and the need for novel and effective therapeutic agents is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca15d090fa39052ab488ff927931345
https://doi.org/10.1080/13543784.2018.1548609
https://doi.org/10.1080/13543784.2018.1548609
Autor:
Hu Zhou, Xiao-Jing Yuan, Mark A. Wainberg, Jian-Min Yue, Ying-Zi Ge, Yechun Xu, Bin Zhou, Ruo-Xuan Xiao, Ying-Shan Han
Publikováno v:
Science China Chemistry. 61:1430-1439
Anti-HIV screening with the MT-4/MTT assay on a focused library of structurally diverse natural products has led to the discovery of a group of steroids with potent activities, which include four new ergostane-type steroids, named amotsterols A-D (1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f6886bdbb0f52b490de0a1f06db3894
https://doi.org/10.1007/s11426-018-9283-3
https://doi.org/10.1007/s11426-018-9283-3
Publikováno v:
Expert Opinion on Investigational Drugs. 26:1207-1213
To date, three HIV integrase strand transfer inhibitors (INSTIs), i.e. raltegravir, elvitegravir and dolutegravir, have been approved for clinical use. Recent research has focused on new integrase inhibitors including those targeting non-catalytic si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58554d9a3c6a4201786f59cc0ca459dd
https://doi.org/10.1080/13543784.2017.1378643
https://doi.org/10.1080/13543784.2017.1378643
Publikováno v:
Infection, Genetics and Evolution. 46:286-291
Three integrase strand transfer inhibitors (INSTIs), raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG), have been approved by the FDA. Resistance against these three INSTIs have been reported and cross-resistance among them has been docume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5057bffa6f0170514b5906f2aefe25
https://doi.org/10.1016/j.meegid.2016.06.047
https://doi.org/10.1016/j.meegid.2016.06.047
Autor:
Hongtao Xu, Ying-Shan Han, Peter A. Crooks, Maureen Oliveira, Thibault Mesplède, Yudong Quan, Mark A. Wainberg, Narsimha Reddy Penthala
Publikováno v:
Journal of Medical Virology. 89:397-407
Dengue virus (DENV) causes a variety of difficult-to-treat diseases that threaten almost half of the world's population. Currently, no effective vaccine or antiviral therapy is available. We have examined a series of synthetic resveratrol analogs to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e76e916a055fdeca83b950fad601baa
https://doi.org/10.1002/jmv.24660
https://doi.org/10.1002/jmv.24660