Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ying Kwong Yee"'
Autor:
Linebarger Jh, Michael Robert Wiley, Leonard C. Weir, Trelia J. Craft, Goodson T, Donetta S. Gifford-Moore, Kyle Ja, Jason Scott Sawyer, Valentine J. Klimkowski, David K. Herron, Anne Louise Tebbe, Smith Gf, Douglas W. Beight, Ying Kwong Yee, Jennifer M. Tinsley, Richard D. Towner
Publikováno v:
Journal of Medicinal Chemistry. 43:873-882
Reversal of the A-ring amide link in 1,2-dibenzamidobenzene 1 (fXa K(ass) = 0.81 x 10(6) L/mol) led to a series of human factor Xa (hfXa) inhibitors based on N(2)-aroylanthranilamide 4. Expansion of the SAR around 4 showed that only small planar subs
Autor:
R D Krell, David W. Snyder, Howard S. Shapiro, Frederick J. Brown, J. J. Maloney, Peter R. Bernstein, Ying Kwong Yee, Edward Vacek, C. L. Lerman, V. G. Matassa, Laura A. Cronk, T. P. Jun. Maduskuie
Publikováno v:
ChemInform. 22
Autor:
Brian J. Eastwood, Guy Milot, Anne Louise Tebbe, Andrew Michael Ratz, Douglas W. Beight, Michael Robert Wiley, Ying Kwong Yee, Steven E. Hall, Leonard C. Weir, Jason Scott Sawyer, Jennifer M. Tinsley, Kyle Ja, Jeffry Bernard Franciskovich, Joseph John Masters, David Mendel, Richard D. Towner, Valentine J. Klimkowski, Smith Gf, Trelia J. Craft, James H. Wikel, David K. Herron, Donetta S. Gifford-Moore, Goodson T
Publikováno v:
Journal of medicinal chemistry. 43(5)
High-throughput screening of a combinatorial library of diamidophenols yielded lead compounds with the ability to inhibit human factor Xa (fXa) at micromolar concentrations (e.g. compound 4, fXa apparent K(ass) = 0.64 x 10(6) L/mol). SAR studies in t