Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Ying K Tam"'
Autor:
Moritz Thran, Jean Mukherjee, Marion Pönisch, Katja Fiedler, Andreas Thess, Barbara L Mui, Michael J Hope, Ying K Tam, Nigel Horscroft, Regina Heidenreich, Mariola Fotin‐Mleczek, Charles B Shoemaker, Thomas Schlake
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 10, Pp 1434-1447 (2017)
Abstract The delivery of genetic information has emerged as a valid therapeutic approach. Various reports have demonstrated that mRNA, besides its remarkable potential as vaccine, can also promote expression without inducing an adverse immune respons
Externí odkaz:
https://doaj.org/article/e38e62606e0c43b694eb441946af61b3
Autor:
Justin B Lee, Kaixin Zhang, Yuen Yi C Tam, Joslyn Quick, Ying K Tam, Paulo JC Lin, Sam Chen, Yan Liu, Jayaprakash K Nair, Ivan Zlatev, Kallanthottathil G Rajeev, Muthiah Manoharan, Paul S Rennie, Pieter R Cullis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expressi
Externí odkaz:
https://doaj.org/article/6f4fc54f8a004c18b091a7dfbda75b0a
Autor:
Barbara L Mui, Ying K Tam, Muthusamy Jayaraman, Steven M Ansell, Xinyao Du, Yuen Yi C Tam, Paulo JC Lin, Sam Chen, Jayaprakash K Narayanannair, Kallanthottathil G Rajeev, Muthiah Manoharan, Akin Akinc, Martin A Maier, Pieter Cullis, Thomas D Madden, Michael J Hope
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Lipid nanoparticles (LNPs) encapsulating short interfering RNAs that target hepatic genes are advancing through clinical trials, and early results indicate the excellent gene silencing observed in rodents and nonhuman primates also translates to huma
Externí odkaz:
https://doaj.org/article/f5677ebf4c334dbe9c9d38a4979393bb
Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
Autor:
Nathan M Belliveau, Jens Huft, Paulo JC Lin, Sam Chen, Alex KK Leung, Timothy J Leaver, Andre W Wild, Justin B Lee, Robert J Taylor, Ying K Tam, Carl L Hansen, Pieter R Cullis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Lipid nanoparticles (LNP) are the leading systems for in vivo delivery of small interfering RNA (siRNA) for therapeutic applications. Formulation of LNP siRNA systems requires rapid mixing of solutions containing cationic lipid with solutions contain
Externí odkaz:
https://doaj.org/article/0c307fb90bf9468baca62b6496dabe0e
Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines
Autor:
John S. Tregoning, David C. Stirling, Ziyin Wang, Katie E. Flight, Jonathan C. Brown, Anna K. Blakney, Paul F. McKay, Robert F. Cunliffe, Valarmathy Murugaiah, Christopher B. Fox, Mitchell Beattie, Ying K. Tam, Cecilia Johansson, Robin J. Shattock
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 29-42 (2023)
To be effective, RNA vaccines require both in situ translation and the induction of an immune response to recruit cells to the site of immunization. These factors can pull in opposite directions with the inflammation reducing expression of the vaccin
Externí odkaz:
https://doaj.org/article/0d6a34fafa0d4648b2111c1434bf06b4
Autor:
Clifford T. H. Hayashi, Yi Cao, Leor C. Clark, Abhai K. Tripathi, Fidel Zavala, Garima Dwivedi, James Knox, Mohamad-Gabriel Alameh, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Nirbhay Kumar
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Malaria is a deadly disease responsible for between 550,000 and 627,000 deaths annually. There is a pressing need to develop vaccines focused on malaria elimination. The complex lifecycle of Plasmodium falciparum provides opportunities not o
Externí odkaz:
https://doaj.org/article/5ee49b242f0f42e2a68eb0e937a5e7d5
Autor:
Ishita N. Waghela, Katherine L. Mallory, Justin A. Taylor, Cosette G. Schneider, Tatyana Savransky, Chris J. Janse, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Evelina Angov
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The secreted malarial protein, Cell-Traversal protein for Ookinetes and Sporozoites (CelTOS), is highly conserved among Plasmodium species, and plays a role in the invasion of mosquito midgut cells and hepatocytes in the vertebrate host. CelTOS was i
Externí odkaz:
https://doaj.org/article/288fe199656c4f45939cd999d667f874
Autor:
Alec W. Freyn, Matthew Pine, Victoria C. Rosado, Marcel Benz, Hiromi Muramatsu, Mitchell Beattie, Ying K. Tam, Florian Krammer, Peter Palese, Raffael Nachbagauer, Meagan McMahon, Norbert Pardi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 84-95 (2021)
Nucleoside-modified, lipid nanoparticle-encapsulated mRNAs have recently emerged as suitable vaccines for influenza viruses and other pathogens in part because the platform allows delivery of multiple antigens in a single immunization. mRNA vaccines
Externí odkaz:
https://doaj.org/article/170090d7563642ec8a6592c47132c75d
Autor:
Chutamath Sittplangkoon, Mohamad-Gabriel Alameh, Drew Weissman, Paulo J. C. Lin, Ying K. Tam, Eakachai Prompetchara, Tanapat Palaga
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
An mRNA with unmodified nucleosides induces type I interferons (IFN-I) through the stimulation of innate immune sensors. Whether IFN-I induced by mRNA vaccine is crucial for anti-tumor immune response remains to be elucidated. In this study, we inves
Externí odkaz:
https://doaj.org/article/d82af9ac297f4c658fd7c70b4472e301
Autor:
Katherine L. Mallory, Justin A. Taylor, Xiaoyan Zou, Ishita N. Waghela, Cosette G. Schneider, Michael Q. Sibilo, Neeraja M. Punde, Leah C. Perazzo, Tatyana Savransky, Martha Sedegah, Sheetij Dutta, Chris J. Janse, Norbert Pardi, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Evelina Angov
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract Human malaria affects the vast majority of the world’s population with the Plasmodium falciparum species causing the highest rates of morbidity and mortality. With no licensed vaccine and leading candidates achieving suboptimal protection
Externí odkaz:
https://doaj.org/article/e05bb1dcc8a24bf8950c79ee7ff517fc