Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Ying K Tam"'
Autor:
Moritz Thran, Jean Mukherjee, Marion Pönisch, Katja Fiedler, Andreas Thess, Barbara L Mui, Michael J Hope, Ying K Tam, Nigel Horscroft, Regina Heidenreich, Mariola Fotin‐Mleczek, Charles B Shoemaker, Thomas Schlake
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 10, Pp 1434-1447 (2017)
Abstract The delivery of genetic information has emerged as a valid therapeutic approach. Various reports have demonstrated that mRNA, besides its remarkable potential as vaccine, can also promote expression without inducing an adverse immune respons
Externí odkaz:
https://doaj.org/article/e38e62606e0c43b694eb441946af61b3
Autor:
Justin B Lee, Kaixin Zhang, Yuen Yi C Tam, Joslyn Quick, Ying K Tam, Paulo JC Lin, Sam Chen, Yan Liu, Jayaprakash K Nair, Ivan Zlatev, Kallanthottathil G Rajeev, Muthiah Manoharan, Paul S Rennie, Pieter R Cullis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expressi
Externí odkaz:
https://doaj.org/article/6f4fc54f8a004c18b091a7dfbda75b0a
Autor:
Barbara L Mui, Ying K Tam, Muthusamy Jayaraman, Steven M Ansell, Xinyao Du, Yuen Yi C Tam, Paulo JC Lin, Sam Chen, Jayaprakash K Narayanannair, Kallanthottathil G Rajeev, Muthiah Manoharan, Akin Akinc, Martin A Maier, Pieter Cullis, Thomas D Madden, Michael J Hope
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Lipid nanoparticles (LNPs) encapsulating short interfering RNAs that target hepatic genes are advancing through clinical trials, and early results indicate the excellent gene silencing observed in rodents and nonhuman primates also translates to huma
Externí odkaz:
https://doaj.org/article/f5677ebf4c334dbe9c9d38a4979393bb
Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
Autor:
Nathan M Belliveau, Jens Huft, Paulo JC Lin, Sam Chen, Alex KK Leung, Timothy J Leaver, Andre W Wild, Justin B Lee, Robert J Taylor, Ying K Tam, Carl L Hansen, Pieter R Cullis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Lipid nanoparticles (LNP) are the leading systems for in vivo delivery of small interfering RNA (siRNA) for therapeutic applications. Formulation of LNP siRNA systems requires rapid mixing of solutions containing cationic lipid with solutions contain
Externí odkaz:
https://doaj.org/article/0c307fb90bf9468baca62b6496dabe0e
Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines
Autor:
John S. Tregoning, David C. Stirling, Ziyin Wang, Katie E. Flight, Jonathan C. Brown, Anna K. Blakney, Paul F. McKay, Robert F. Cunliffe, Valarmathy Murugaiah, Christopher B. Fox, Mitchell Beattie, Ying K. Tam, Cecilia Johansson, Robin J. Shattock
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 29-42 (2023)
To be effective, RNA vaccines require both in situ translation and the induction of an immune response to recruit cells to the site of immunization. These factors can pull in opposite directions with the inflammation reducing expression of the vaccin
Externí odkaz:
https://doaj.org/article/0d6a34fafa0d4648b2111c1434bf06b4
Autor:
Jennifer Connors, David Joyner, Nathan J. Mege, Gina M. Cusimano, Matthew R. Bell, Jennifer Marcy, Bhavani Taramangalam, Kenneth M. Kim, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Michele A. Kutzler, Mohamad-Gabriel Alameh, Elias K. Haddad
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
The role of empty lipid nanoparticles in eliciting dendritic cell maturation and innate immune signaling is shown to be impaired in older adults, potentially contributing to lower immune responses to SARS-CoV-2 mRNA-based vaccines.
Externí odkaz:
https://doaj.org/article/f939a91eb95f4c4fb669b5245aa1ee19
Autor:
Clifford T. H. Hayashi, Yi Cao, Leor C. Clark, Abhai K. Tripathi, Fidel Zavala, Garima Dwivedi, James Knox, Mohamad-Gabriel Alameh, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Nirbhay Kumar
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Malaria is a deadly disease responsible for between 550,000 and 627,000 deaths annually. There is a pressing need to develop vaccines focused on malaria elimination. The complex lifecycle of Plasmodium falciparum provides opportunities not o
Externí odkaz:
https://doaj.org/article/5ee49b242f0f42e2a68eb0e937a5e7d5
Autor:
Brandon Carter, Pinghan Huang, Ge Liu, Yuejin Liang, Paulo J. C. Lin, Bi-Hung Peng, Lindsay G. A. McKay, Alexander Dimitrakakis, Jason Hsu, Vivian Tat, Panatda Saenkham-Huntsinger, Jinjin Chen, Clarety Kaseke, Gaurav D. Gaiha, Qiaobing Xu, Anthony Griffiths, Ying K. Tam, Chien-Te K. Tseng, David K. Gifford
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Licensed COVID-19 vaccines ameliorate viral infection by inducing production of neutralizing antibodies that bind the SARS-CoV-2 Spike protein and inhibit viral cellular entry. However, the clinical effectiveness of these vaccines is transitory as vi
Externí odkaz:
https://doaj.org/article/37d4703fe4c94f879a346594ee70e087
Autor:
Clifford T. H. Hayashi, Yi Cao, Leor C. Clark, Abhai K. Tripathi, Fidel Zavala, Garima Dwivedi, James Knox, Mohamad-Gabriel Alameh, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Nirbhay Kumar
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/567bf426669a49e5821095f8e4be4774
Autor:
Ishita N. Waghela, Katherine L. Mallory, Justin A. Taylor, Cosette G. Schneider, Tatyana Savransky, Chris J. Janse, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Evelina Angov
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The secreted malarial protein, Cell-Traversal protein for Ookinetes and Sporozoites (CelTOS), is highly conserved among Plasmodium species, and plays a role in the invasion of mosquito midgut cells and hepatocytes in the vertebrate host. CelTOS was i
Externí odkaz:
https://doaj.org/article/288fe199656c4f45939cd999d667f874