Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ying Hua Cheng"'
Autor:
Debora L. Gisch, Michelle Brennan, Blue B. Lake, Jeannine Basta, Mark S. Keller, Ricardo Melo Ferreira, Shreeram Akilesh, Reetika Ghag, Charles Lu, Ying-Hua Cheng, Kimberly S. Collins, Samir V. Parikh, Brad H. Rovin, Lynn Robbins, Lisa Stout, Kimberly Y. Conklin, Dinh Diep, Bo Zhang, Amanda Knoten, Daria Barwinska, Mahla Asghari, Angela R. Sabo, Michael J. Ferkowicz, Timothy A. Sutton, Katherine J. Kelly, Ian H. De Boer, Sylvia E. Rosas, Krzysztof Kiryluk, Jeffrey B. Hodgin, Fadhl Alakwaa, Seth Winfree, Nichole Jefferson, Aydın Türkmen, Joseph P. Gaut, Nils Gehlenborg, Carrie L. Phillips, Tarek M. El-Achkar, Pierre C. Dagher, Takashi Hato, Kun Zhang, Jonathan Himmelfarb, Matthias Kretzler, Shamim Mollah, the Kidney Precision Medicine Project (KPMP), Sanjay Jain, Michael Rauchman, Michael T. Eadon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract There is a need to define regions of gene activation or repression that control human kidney cells in states of health, injury, and repair to understand the molecular pathogenesis of kidney disease and design therapeutic strategies. Comprehe
Externí odkaz:
https://doaj.org/article/8d81e0f3c4d54dd6b9a6681fc0df894c
Autor:
Victor Hugo Canela, William S. Bowen, Ricardo Melo Ferreira, Farooq Syed, James E. Lingeman, Angela R. Sabo, Daria Barwinska, Seth Winfree, Blue B. Lake, Ying-Hua Cheng, Joseph P. Gaut, Michael Ferkowicz, Kaice A. LaFavers, Kun Zhang, Fredric L. Coe, Elaine Worcester, the Kidney Precision Medicine Project, Sanjay Jain, Michael T. Eadon, James C. Williams, Tarek M. El-Achkar
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Kidney stone disease causes significant morbidity and increases health care utilization. In this work, we decipher the cellular and molecular niche of the human renal papilla in patients with calcium oxalate (CaOx) stone disease and healthy
Externí odkaz:
https://doaj.org/article/9079daace87a49889ca16163b6717e46
Autor:
Ricardo Melo Ferreira, Angela R. Sabo, Seth Winfree, Kimberly S. Collins, Danielle Janosevic, Connor J. Gulbronson, Ying-Hua Cheng, Lauren Casbon, Daria Barwinska, Michael J. Ferkowicz, Xiaoling Xuei, Chi Zhang, Kenneth W. Dunn, Katherine J. Kelly, Timothy A. Sutton, Takashi Hato, Pierre C. Dagher, Tarek M. El-Achkar, Michael T. Eadon
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Single-cell sequencing studies have characterized the transcriptomic signature of cell types within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional and affects cells heterogeneously. We first optimized coordinat
Externí odkaz:
https://doaj.org/article/71daba4ad199461d95bffa086ab6c6bf
Autor:
Danielle Janosevic, Jered Myslinski, Thomas W McCarthy, Amy Zollman, Farooq Syed, Xiaoling Xuei, Hongyu Gao, Yun-Long Liu, Kimberly S Collins, Ying-Hua Cheng, Seth Winfree, Tarek M El-Achkar, Bernhard Maier, Ricardo Melo Ferreira, Michael T Eadon, Takashi Hato, Pierre C Dagher
Publikováno v:
eLife, Vol 10 (2021)
Sepsis is a dynamic state that progresses at variable rates and has life-threatening consequences. Staging patients along the sepsis timeline requires a thorough knowledge of the evolution of cellular and molecular events at the tissue level. Here, w
Externí odkaz:
https://doaj.org/article/95a72248ab2e4edb9c901a6ce089d3b0
Autor:
Kimberly S. Collins, Michael T. Eadon, Ying-Hua Cheng, Daria Barwinska, Ricardo Melo Ferreira, Thomas W. McCarthy, Danielle Janosevic, Farooq Syed, Bernhard Maier, Tarek M. El-Achkar, Katherine J. Kelly, Carrie L. Phillips, Takashi Hato, Timothy A. Sutton, Pierre C. Dagher
Publikováno v:
Cells, Vol 11, Iss 7, p 1166 (2022)
Diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease despite decades of study. Alterations in the glomerulus and kidney tubules both contribute to the pathogenesis of DKD although the majority of investigative efforts h
Externí odkaz:
https://doaj.org/article/205429c7ae6b47a2a1e7eb5f55018578
Autor:
Pierre C. Dagher, Tarek M. El-Achkar, Jeanette N. McClintick, Michael T. Eadon, Megan L. Noonan, Danielle Janosevic, Pu Ni, Joseph M. Richardville, Kenneth E. White, Takashi Hato, Ying-Hua Cheng, Erica L. Clinkenbeard
Publikováno v:
Kidney International. 99:598-608
Fibroblast Growth Factor 23 (FGF23) is a bone-derived hormone that reduces kidney phosphate reabsorption and 1,25(OH)2 vitamin D synthesis via its required co-receptor alpha-Klotho. To identify novel genes that could serve as targets to control FGF23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4eac387f3ace2856e91375b0496eb51
https://doi.org/10.1016/j.kint.2020.10.024
https://doi.org/10.1016/j.kint.2020.10.024
Autor:
Ying Hua Cheng, Chloe White, Pierre C. Dagher, Nida A. Khan, Ricardo Melo Ferreira, Danielle Janosevic, Michael T. Eadon, Kimberly S. Collins, Matthew D. Dollins, Hongyu Gao
Publikováno v:
Clinical and Translational Science
Mycophenolic acid (MPA) is an immunosuppressant commonly used to prevent renal transplant rejection and treat glomerulonephritis. MPA inhibits IMPDH2 within stimulated lymphocytes, reducing guanosine synthesis. Despite the widespread use of MPA, inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a071839730edfacf00fbb96e0d6c6c08
https://doi.org/10.1111/cts.12795
https://doi.org/10.1111/cts.12795
Publikováno v:
Proceedings of IMPRS. 4
Background: Worldwide, one in eleven adults have diabetes mellitus and 30% to 40% will develop diabetic kidney disease (DKD). A mechanistic understanding of DKD is crucial to develop treatment strategies. To unravel DKD’s pathogenesis, single cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::790e76ca280da59e0a6bb20904b630ad
https://doi.org/10.18060/25926
https://doi.org/10.18060/25926
The tissue in OCT undergoes cryosectioning, affixment to the cDNA capture slide, H+E staining, 20x Keyence imaging, tissue permeabilization, RNA capture, and cDNA synthesis. Data is analyzed in Loupe browser and in R prior to uploading to the KPMP Da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa870e81f2cc11fb694178e4279424d
https://doi.org/10.17504/protocols.io.bz5hp836
https://doi.org/10.17504/protocols.io.bz5hp836
Autor:
Kenneth W. Dunn, Lauren Casbon, Tarek M. El-Achkar, Chi Zhang, Michael J. Ferkowicz, Timothy A. Sutton, Pierre C. Dagher, Connor J Gulbronson, Ying-Hua Cheng, Xiaoling Xuei, Danielle Janosevic, Takashi Hato, Angela R Sabo, Michael T. Eadon, Ricardo Melo Ferreira, Kimberly S. Collins, Daria Barwinska, Seth Winfree, Katherine J. Kelly
Publikováno v:
JCI Insight
Single-cell sequencing studies have characterized the transcriptomic signature of cell types within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional and affects cells heterogeneously. We first optimized coordinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2537aa6e27c064cb8cc1f782bf9986
https://doi.org/10.1172/jci.insight.147703
https://doi.org/10.1172/jci.insight.147703