Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ying Ching Liang"'
Long-term potentiation at excitatory synaptic inputs to the intercalated cell masses of the amygdala
Publikováno v:
The International Journal of Neuropsychopharmacology. 17:1233-1242
The intercalated cell masses (ITCs) of the amygdala are clusters of GABAergic interneurons that surround the basolateral complex of the amygdala. ITCs have been increasingly implicated in the acquisition and extinction of conditioned fear responses,
Publikováno v:
Pain. 153:2097-2108
The anterior cingulate cortex (ACC) has been shown to play an important role in pain-related perception and chronic pain. However, little is known about the molecular mechanisms involved. To address this issue, we analyzed excitatory synaptic transmi
Publikováno v:
The International Journal of Neuropsychopharmacology. 14:431-443
Prenatal exposure to cocaine has been reported to produce long-lasting cognitive deficits, but the underlying mechanisms remain largely unknown. Here, we report that the induction of long-term potentiation (LTP) at excitatory synapses onto layer V py
Estrogen modulates sexually dimorphic contextual fear extinction in rats through estrogen receptor β
Publikováno v:
Hippocampus. 19:1142-1150
Females and males are different in brain and behavior. These sex differences occur early during development due to a combination of genetic and hormonal factors and continue throughout the lifespan. Previous studies revealed that male rats exhibited
Publikováno v:
Neuropsychopharmacology. 34:1979-1992
Neural adaptations in the medial prefrontal cortex (mPFC) are thought to be crucial in the development and maintenance of addictive behaviors. The mPFC receives a dense serotonergic (5-hydroxytryptamine, 5-HT) innervation from raphe nuclei and 5-HT e
Publikováno v:
Pain. 114:417-428
Recent work has demonstrated that a brief high-frequency conditioning stimulation to the primary afferent nerve fibers can induce a long-term potentiation (LTP) of synaptic transmission in neurons in the superficial layer of the trigeminal caudal nuc
Publikováno v:
Current Drug Target -CNS & Neurological Disorders. 3:507-514
Trigeminal neuralgia is a disorder of paroxysmal and severely disabling facial pain and continues to be a real therapeutic challenge to the clinicians. While the exact cause and pathology of this disorder is uncertain, it is thought that trigeminal n
Publikováno v:
The Journal of Physiology. 555:85-96
Systemic or intraventricular administration of cannabinoids causes analgesic effects, but relatively little is known for their cellular mechanism. Using brainstem slices with the mandibular nerve attached, we examined the effect of cannabinoids on gl
Publikováno v:
Molecular neurobiology. 52(3)
We previously reported that animals withdrawn from repeated cocaine exposure exhibited a selective deficit in the ability to elicit metabotropic glutamate receptor 5 (mGluR5)-dependent long-term depression (LTD) in the nucleus accumbens (NAc) shell.
Publikováno v:
Journal of Biological Chemistry. 276:48108-48117
Reversal of long term potentiation (LTP) may function to increase the flexibility and storage capacity of neuronal circuits; however, the underlying mechanisms remain incompletely understood. We show that depotentiation induced by low frequency stimu