Imperatorin ameliorates learning and memory deficits through BDNF / TrkB and ERK / CaMKIIα / CREB signaling in prenatally‐stressed female offspring

Autor: Yi W. Chen, Ying C. Li, Huan H. Deng, Hui L. Jing, Yan J. Cao, Kai Y. Zhang, Yang Li, Si Z. Xia, Xing X. Zheng, Yi S. Yue

Publikováno v: Phytotherapy Research. 34:2408-2418

Prenatal stress (PS) can lead to impaired spatial learning and memory in offspring. Imperatorin (IMP) is a naturally occurring furanocoumarin with many pharmacological properties. However, the effects of IMP on cognitive impairment induced by PS and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::328cc33f619e9c21400241e6b999f3f3
https://doi.org/10.1002/ptr.6692

Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets

Autor: Ege T. Kavalali, Ying C. Li

Publikováno v: Pharmacological Reviews. 69:141-160

Presynaptic nerve terminals are highly specialized vesicle-trafficking machines. Neurotransmitter release from these terminals is sustained by constant local recycling of synaptic vesicles independent from the neuronal cell body. This independence pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8524cc3df43cedfe43dd07ab57b85e2d
https://doi.org/10.1124/pr.116.013342

Synaptotagmin-1- and Synaptotagmin-7-Dependent Fusion Mechanisms Target Synaptic Vesicles to Kinetically Distinct Endocytic Pathways

Autor: Ege T. Kavalali, Wei Xu, Ying C. Li, Natali L. Chanaday

Publikováno v: Neuron. 93(3)

Synaptic vesicle recycling is essential for maintaining normal synaptic function. The coupling of exocytosis and endocytosis is assumed to be Ca2+ dependent, but the exact role of Ca2+ and its key effector synaptotagmin-1 (syt1) in regulation of endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1195eb0aaf60686d54d5c0727d1eb379
https://pubmed.ncbi.nlm.nih.gov/28111077

VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission

Autor: Jesica Raingo, Denise M.O. Ramirez, Ying C. Li, Mikhail Khvotchev, Ege T. Kavalali, Megumi Adachi, Frédéric Darios, Katalin Tóth, Pei Liu, Philippe Lemieux, Bazbek Davletov

Publikováno v: Nature neuroscience

The authors show that the SNARE protein VAMP4 acts to maintain calcium-dependent asynchronous synaptic vesicle release. These findings suggest that VAMP4 is functionally distinct from synaptobrevin2, which primarily drives fast, synchronous release.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e85282362c39294c038d5c83571702

Addressing non-response data for standardized post-acute functional items.

Autor: Li C-; Department of Occupational Therapy, School of Health Professions, University of Texas Medical Branch, Rm 3.906, 301 University Blvd., Galveston, TX, 77555-1142, USA. chili@utmb.edu.; Department of Population Health and Health Disparities, School of Public and Population Health, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555, USA. chili@utmb.edu., Kim H; Office of Biostatistics, Department of Preventive Medicine & Public Health, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555-1148, USA., Downer B; Department of Population Health and Health Disparities, School of Public and Population Health, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555, USA., Lee MJ; Department of Nutrition, Metabolism, and Rehabilitation Sciences, School of Health Professions, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555, USA., Ottenbacher K; Department of Nutrition, Metabolism, and Rehabilitation Sciences, School of Health Professions, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555, USA., Kuo YF; Office of Biostatistics, Department of Preventive Medicine & Public Health, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555-1148, USA.; Sealy Center On Aging, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555-0177, USA.

Publikováno v: BMC health services research [BMC Health Serv Res] 2023 Sep 06; Vol. 23 (1), pp. 955. Date of Electronic Publication: 2023 Sep 06.