Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Ying Ann Chiao"'
Autor:
Kylene M. Harold, Satoshi Matsuzaki, Atul Pranay, Brooke L. Loveland, Albert Batushansky, Maria F. Mendez Garcia, Craig Eyster, Stavros Stavrakis, Ying Ann Chiao, Michael Kinter, Kenneth M. Humphries
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 7 (2024)
Background Phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase (PFK‐2) is a critical glycolytic regulator responsible for upregulation of glycolysis in response to insulin and adrenergic signaling. PFKFB2, the cardiac isoform of PFK‐2, is
Externí odkaz:
https://doaj.org/article/7b80fa90133942b79d878e1f4b38ac6e
Autor:
Maria F. Mendez Garcia, Satoshi Matsuzaki, Albert Batushansky, Ryan Newhardt, Caroline Kinter, Yan Jin, Shivani N. Mann, Michael B. Stout, Haiwei Gu, Ying Ann Chiao, Michael Kinter, Kenneth M. Humphries
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107131- (2023)
Summary: A healthy heart adapts to changes in nutrient availability and energy demands. In metabolic diseases like type 2 diabetes (T2D), increased reliance on fatty acids for energy production contributes to mitochondrial dysfunction and cardiomyopa
Externí odkaz:
https://doaj.org/article/ffdebaa794634e58a940833770287078
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Heart failure with preserved ejection fraction (HFpEF) is a multi-organ disorder that represents about 50% of total heart failure (HF) cases and is the most common form of HF in the elderly. Because of its increasing prevalence caused by the aging po
Externí odkaz:
https://doaj.org/article/49800a62740f4eb3a65d952618c3af11
Autor:
Ying Ann Chiao, Huiliang Zhang, Mariya Sweetwyne, Jeremy Whitson, Ying Sonia Ting, Nathan Basisty, Lindsay K Pino, Ellen Quarles, Ngoc-Han Nguyen, Matthew D Campbell, Tong Zhang, Matthew J Gaffrey, Gennifer Merrihew, Lu Wang, Yongping Yue, Dongsheng Duan, Henk L Granzier, Hazel H Szeto, Wei-Jun Qian, David Marcinek, Michael J MacCoss, Peter Rabinovitch
Publikováno v:
eLife, Vol 9 (2020)
Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial targeted peptide SS-31 (elamipretide) can substantially reverse this deficit. SS-31 normalize
Externí odkaz:
https://doaj.org/article/720f135c89f7440e948956a2b4dd4a5d
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2039 (2021)
Free radicals, or reactive oxygen species, have been implicated as one of the primary causes of myocardial pathologies elicited by chronic diseases and age. The imbalance between pro-oxidants and antioxidants, termed “oxidative stress”, involves
Externí odkaz:
https://doaj.org/article/2e36732bc189469998f0f13eb245fc50
Autor:
Harold, Kylene M., Satoshi Matsuzaki, Pranay, Atul, Loveland, Brooke L., Batushansky, Albert, Garcia, Maria F. Mendez, Eyster, Craig, Stavrakis, Stavros, Ying Ann Chiao, Kinter, Michael, Humphries, Kenneth M.
Publikováno v:
Journal of the American Heart Association; 4/2/2024, Vol. 13 Issue 7, p1-20, 20p
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(4)
Nicotinamide adenine dinucleotide (NAD
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H774-H781
We examined the effects of SARM1 deletion on NAD+ pool, transcripts of NAD+ metabolism, and fibrotic pathway for the first time in mouse hearts. We observed the sexually dimorphic effects of SARM1 deletion. How these sex-dependent effects influence t
Publikováno v:
Current Heart Failure Reports. 19:157-169
Autor:
Matthew D. Campbell, Ashton T. Samuelson, Ying Ann Chiao, Mariya T. Sweetwyne, Warren C. Ladiges, Peter S. Rabinovitch, David J. Marcinek
Publikováno v:
GeroScience.
The pathology of aging impacts multiple organ systems including the kidney, skeletal, and cardiac muscle. Long-term treatment with the mitochondrial targeted peptide elamipretide has previously been shown to improvein vivomitochondrial function in ag