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Akademický článek

Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent

Autor: Luise Westernberg, Claire Conche, Yina Hsing Huang, Stephanie Rigaud, Yisong Deng, Sabine Siegemund, Sayak Mukherjee, Lyn'Al Nosaka, Jayajit Das, Karsten Sauer

Publikováno v: eLife, Vol 5 (2016)

β-selection is the most pivotal event determining αβ T cell fate. Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation. Besides the pre-TCR, β-selection al

Externí odkaz: https://doaj.org/article/1ae57ac0454547c3a658659fd48d389b

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Akademický článek

Lipid and protein co-regulation of PI3K effectors Akt and Itk in lymphocytes

Autor: Xinxin eWang, Leonard Benjamin Hills, Yina Hsing Huang

Publikováno v: Frontiers in Immunology, Vol 6 (2015)

The phosphoinositide 3-kinase (PI 3-kinase, PI3K) pathway transduces signals critical for lymphocyte function. PI3K generates the phospholipid PIP3 at the plasma membrane to recruit proteins that contain pleckstrin homology (PH) domains – a conserv

Externí odkaz: https://doaj.org/article/8f01f879a5264b289d50ee40d69a7306

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Molecular Mechanisms of B Lymphocyte Activation by the Immune Response Modifier R-848

Autor: Gail A. Bishop, M A Tomai, Sangita V. Jalukar, Yina Hsing, Luis M. Ramirez, Bruce S. Hostager

Publikováno v: The Journal of Immunology. 165:5552-5557

The imidazoquinoline R-848, originally identified as a highly effective antiviral agent, has recently been shown to be capable of potent B lymphocyte activation. The B cell-activating properties of R-848 are strikingly similar to the effects of the C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7d6dcc276e5a26a8821528129c33a2
https://doi.org/10.4049/jimmunol.165.10.5552

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Requirement for Nuclear Factor-κB Activation by a Distinct Subset of CD40-Mediated Effector Functions in B Lymphocytes

Autor: Yina Hsing, Gail A. Bishop

Publikováno v: The Journal of Immunology. 162:2804-2811

CD40 stimulation, which is crucial for generating an effective T-dependent humoral response, leads to the activation of transcription factors NF-AT (nuclear factor of activated T cells), AP-1 (activator protein-1), and NF-κB (nuclear factor-κB). Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7a91040f0c9873ae10bfaadf20a4deb
https://doi.org/10.4049/jimmunol.162.5.2804

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