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Akademický článek

Bulk anda single-cell transcriptome profiling reveals the molecular characteristics of T cell-mediated tumor killing in pancreatic cancer

Autor: Yin-wei Dai, Ya-ting Pan, Dan-feng Lin, Xiao-hu Chen, Xiang Zhou, Wei-ming Wang

Publikováno v: Heliyon, Vol 10, Iss 5, Pp e27216- (2024)

Background: Despite the potential of immune checkpoint blockade (ICB) as a promising treatment for Pancreatic adenocarcinoma (PAAD), there is still a need to identify specific subgroups of PAAD patients who may benefit more from ICB. T cell-mediated

Externí odkaz: https://doaj.org/article/c2afd298de364008afb7d125b8e559fd

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Akademický článek

Development of a CD8+ T cell-based molecular classification for predicting prognosis and heterogeneity in triple-negative breast cancer by integrated analysis of single-cell and bulk RNA-sequencing

Autor: Yin-wei Dai, Wei-ming Wang, Xiang Zhou

Publikováno v: Heliyon, Vol 9, Iss 9, Pp e19798- (2023)

Background: Triple-negative breast cancer (TNBC), although the most intractable subtype, is characterized by abundant immunogenicity, which enhances responsiveness to immunotherapeutic measures. Methods: First, we identified CD8+ T cell core genes (T

Externí odkaz: https://doaj.org/article/dbd99fffee8942a3a948cd11b7d06884

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Akademický článek

Characterization of chromatin regulators identified prognosis and heterogeneity in hepatocellular carcinoma

Autor: Yin-wei Dai, Han-bin Chen, Ya-ting Pan, Lin-xi Lv, Wei-ming Wang, Xiao-Hu Chen, Xiang Zhou

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Liver carcinogenesis is a multiprocess that involves complicated interactions between genetics, epigenetics, and transcriptomic alterations. Aberrant chromatin regulator (CR) expressions, which are vital regulatory epigenetics, have been found to be

Externí odkaz: https://doaj.org/article/b348a3a9e60d41cfa62fcd305d6fce2e

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Akademický článek

Amino Acid Metabolism-Related lncRNA Signature Predicts the Prognosis of Breast Cancer

Autor: Yin-wei Dai, Zhi-kai Wen, Zhi-xuan Wu, Hao-dong Wu, Lin-xi Lv, Cong-zhi Yan, Cong-hui Liu, Zi-qiong Wang, Chen Zheng

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Background and Purpose: Breast cancer (BRCA) is the most frequent female malignancy and is potentially life threatening. The amino acid metabolism (AAM) has been shown to be strongly associated with the development and progression of human malignanci

Externí odkaz: https://doaj.org/article/16b797d9144e4840bcbc16ec9efd1c66

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