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of 3
pro vyhledávání: '"Yin-Ta Wu"'
Autor:
Po-Huang Liang, Jim-Min Fang, Jia-Tsrong Jan, Hung-Jyun Huang, Yin-Ta Wu, Jiun-Jie Shie, Tun-Hsun Kuo, Yih-Shyun E. Cheng, Chi-Huey Wong, Chih-Jung Kuo
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract The dipeptide-conjugated ester derived from Phe-Phe dipeptide and 4-(dimethylamino)cinnamic acid shows a potent anti-SARS activity by inhibition of the 3CL protease.
The proteolytic processing of polyproteins by the 3CL protea
The proteolytic processing of polyproteins by the 3CL protea
Autor:
Ana Lucia da Costa, Doman Kim, Hong Quang Nguyen, Paul de Vlieger, Vincent Breton, Young-Min Kim, Nam Hai Truong, Yin-Ta Wu, Lydia Maigne, Romain Reuillon, David Sarramia
Publikováno v:
Infectious disorders drug targets. 9(3)
The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, o
Autor:
Jim-Min Fang, Chih-Jung Kuo, Chun-Hung Lin, Tun-Hsun Kuo, Yin-Ta Wu, Wen-Bin Yang, Hung-Jyun Huang, Jiun-Ling Chen, Chi-Huey Wong, Jiun-Jie Shie, Po-Huang Liang
Publikováno v:
Journal of medicinal chemistry. 48(13)
A diversified library of peptide anilides was prepared, and their inhibition activities against the SARS-CoV 3CL protease were examined by a fluorogenic tetradecapeptide substrate. The most potent inhibitor is an anilide derived from 2-chloro-4-nitro