Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Yin-Biao Sun"'
Autor:
Chengyao Jiang, Xiaoying Zhang, Jiahui Rao, Shu Luo, Liang Luo, Wei Lu, Mengyao Li, Shumei Zhao, Dan Ren, Jiaming Liu, Yu Song, Yangxia Zheng, Yin-Biao Sun
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Kiwifruit bacterial canker, caused by Pseudomonas syringae pv. actinidiae (PSA), poses a grave threat to the global kiwifruit industry. In this study, we examined the role of microRNAs (miRNAs) in kiwifruit’s response to PSA. Kiwifruit seedlings su
Externí odkaz:
https://doaj.org/article/19f278d818b644e688514c2039885243
Publikováno v:
eLife, Vol 6 (2017)
The Frank-Starling relation is a fundamental auto-regulatory property of the heart that ensures the volume of blood ejected in each heartbeat is matched to the extent of venous filling. At the cellular level, heart muscle cells generate higher force
Externí odkaz:
https://doaj.org/article/20dbbd77c4244cd48fe3a024b1103a02
Autor:
Viola F Gnocchi, Juergen Scharner, Zhe Huang, Ken Brady, Jaclyn S Lee, Robert B White, Jennifer E Morgan, Yin-Biao Sun, Juliet A Ellis, Peter S Zammit
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16651 (2011)
LMNA encodes both lamin A and C: major components of the nuclear lamina. Mutations in LMNA underlie a range of tissue-specific degenerative diseases, including those that affect skeletal muscle, such as autosomal-Emery-Dreifuss muscular dystrophy (A-
Externí odkaz:
https://doaj.org/article/73e492a68abf478296efc077c4ca2123
Autor:
Ivanka R. Sevrieva, Saraswathi Ponnam, Ziqian Yan, Malcolm Irving, Thomas Kampourakis, Yin-Biao Sun
Publikováno v:
The Journal of biological chemistry.
Protein kinase A (PKA)-mediated phosphorylation of sarcomeric proteins enhances heart muscle performance in response to β-adrenergic stimulation and is associated with accelerated relaxation and increased cardiac output for a given preload. At the c
Autor:
Yin-Biao Sun, Birgit Brandmeier, Saraswathi Ponnam, Thomas Kampourakis, Kenneth S. Campbell, Malcolm Irving, Mathias Gautel, Ivanka Sevrieva
Publikováno v:
The Journal of Biological Chemistry
Heart muscle contractility and performance are controlled by posttranslational modifications of sarcomeric proteins. Although myosin regulatory light chain (RLC) phosphorylation has been studied extensively in vitro and in vivo, the precise role of c
Autor:
Giancarlo, Abis, Rebecca L, Charles, Jolanta, Kopec, Wyatt W, Yue, R Andrew, Atkinson, Tam T T, Bui, Steven, Lynham, Simona, Popova, Yin-Biao, Sun, Franca, Fraternali, Philip, Eaton, Maria R, Conte
Publikováno v:
Communications Biology
Human soluble epoxide hydrolase (hsEH) is an enzyme responsible for the inactivation of bioactive epoxy fatty acids, and its inhibition is emerging as a promising therapeutical strategy to target hypertension, cardiovascular disease, pain and insulin
Autor:
Yin-Biao Sun, Ziqian Yan, Thomas Kampourakis, Malcolm Irving, Sandra E. Pineda-Sanabria, Brian D. Sykes, Ian M. Robertson
Publikováno v:
Biochemistry. 55:6032-6045
The binding of Ca2+ to cardiac troponin C (cTnC) triggers contraction in heart muscle. In the diseased heart, the myocardium is often desensitized to Ca2+, which leads to impaired contractility. Therefore, compounds that sensitize cardiac muscle to C
Publikováno v:
Biophysical Journal. 118:280a
Publikováno v:
The Journal of biological chemistry. 293(37)
Myosin-binding protein-C (cMyBP-C) is a key regulator of contractility in heart muscle, and its regulatory function is controlled in turn by phosphorylation of multiple serines in its m-domain. The structural and functional effects of m-domain phosph
Autor:
Yin-Biao Sun, Malcolm Irving, Brian D. Sykes, Brittney A. Klein, Liang Li, Béla Reiz, Ian M. Robertson
Publikováno v:
Biochemistry. 57(15)
The development of calcium sensitizers for the treatment of systolic heart failure presents difficulties, including judging the optimal efficacy and the specificity to target cardiac muscle. The thin filament is an attractive target because cardiac t