Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Yin Yeng, Lee"'
Autor:
Bala S C Koritala, Yin Yeng Lee, Laetitia S Gaspar, Shweta S Bhadri, Wen Su, Gang Wu, Lauren J Francey, Marc D Ruben, Ming C Gong, John B Hogenesch, David F Smith
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3002139 (2023)
Intermittent hypoxia (IH) is a major clinical feature of obstructive sleep apnea (OSA). The mechanisms that become dysregulated after periods of exposure to IH are unclear, particularly in the early stages of disease. The circadian clock governs a wi
Externí odkaz:
https://doaj.org/article/e04c4b5965044dc0abdef46011780cda
Autor:
Gang Wu, Yin Yeng Lee, Evelyn M Gulla, Andrew Potter, Joseph Kitzmiller, Marc D Ruben, Nathan Salomonis, Jeffery A Whitsett, Lauren J Francey, John B Hogenesch, David F Smith
Publikováno v:
eLife, Vol 10 (2021)
Obstructive sleep apnea (OSA) results from episodes of airway collapse and intermittent hypoxia (IH) and is associated with a host of health complications. Although the lung is the first organ to sense changes in oxygen levels, little is known about
Externí odkaz:
https://doaj.org/article/9038c96aee5b4a08b50d43bf52f0264b
Publikováno v:
Bioinformatics. 38:5375-5382
Motivation Years of time-series gene expression studies have built a strong understanding of clock-controlled pathways across species. However, comparatively little is known about how ‘non-clock’ pathways influence clock function. We need a stron
Autor:
Rahul Nahar, Weiwei Zhai, Tong Zhang, Angela Takano, Alexis J. Khng, Yin Yeng Lee, Xingliang Liu, Chong Hee Lim, Tina P. T. Koh, Zaw Win Aung, Tony Kiat Hon Lim, Lavanya Veeravalli, Ju Yuan, Audrey S. M. Teo, Cheryl X. Chan, Huay Mei Poh, Ivan M. L. Chua, Audrey Ann Liew, Dawn Ping Xi Lau, Xue Lin Kwang, Chee Keong Toh, Wan-Teck Lim, Bing Lim, Wai Leong Tam, Eng-Huat Tan, Axel M. Hillmer, Daniel S. W. Tan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
EGFR mutant lung adenocarcinoma (LUAD) exhibit diverse clinical outcomes in response to targeted therapies. Here the authors show that these LUADs involve a complex genomic landscape with high intratumor heterogeneity, providing insights into the evo
Externí odkaz:
https://doaj.org/article/358b10958e814ff3ae9b2917b6e35d5b
Autor:
Daniel S.W. Tan, Anders J. Skanderup, Axel M. Hillmer, Weiwei Zhai, Eng-Huat Tan, Wai Leong Tam, N. Gopalakrishna Iyer, Wan-Teck Lim, Chee Keong Toh, Lisda Suteja, Ming Jie Lim, Alexis Jiaying Khng, Audrey S.M. Teo, Lanying Wang, Yin Yeng Lee, Bien Soo Tan, Ghee Chee Phua, Devanand Anantham, Tanujaa Rajasekaran, Mei Kim Ang, Quan Sing Ng, Ravindran Kanesvaran, Chow Wei Too, Apoorva Gogna, Wan Ling Tan, Amit Jain, Irfahan Kassam, Marjan Mojtabavi Naeini, Kiat Hon Lim, Joe P.S. Yeong, Zaw Win Aung, Gillianne G.Y. Lai, Neha Rohatgi, Rahul Nahar, Jacob J.S. Alvarez, Angela Takano, Aaron C. Tan, Yvonne H.F. Teng, Khi Pin Chua
Purpose:Despite the established role of EGFR tyrosine kinase inhibitors (TKIs) in EGFR-mutated NSCLC, drug resistance inevitably ensues, with a paucity of treatment options especially in EGFRT790M-negative resistance.Experimental Design:We performed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227b720107cfdf35e476c0479af15bbd
https://doi.org/10.1158/1078-0432.c.6530516.v1
https://doi.org/10.1158/1078-0432.c.6530516.v1
Autor:
Daniel S.W. Tan, Anders J. Skanderup, Axel M. Hillmer, Weiwei Zhai, Eng-Huat Tan, Wai Leong Tam, N. Gopalakrishna Iyer, Wan-Teck Lim, Chee Keong Toh, Lisda Suteja, Ming Jie Lim, Alexis Jiaying Khng, Audrey S.M. Teo, Lanying Wang, Yin Yeng Lee, Bien Soo Tan, Ghee Chee Phua, Devanand Anantham, Tanujaa Rajasekaran, Mei Kim Ang, Quan Sing Ng, Ravindran Kanesvaran, Chow Wei Too, Apoorva Gogna, Wan Ling Tan, Amit Jain, Irfahan Kassam, Marjan Mojtabavi Naeini, Kiat Hon Lim, Joe P.S. Yeong, Zaw Win Aung, Gillianne G.Y. Lai, Neha Rohatgi, Rahul Nahar, Jacob J.S. Alvarez, Angela Takano, Aaron C. Tan, Yvonne H.F. Teng, Khi Pin Chua
Supplementary Data from Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166d4b020fca17d01eb4115553cc3afd
https://doi.org/10.1158/1078-0432.22480715
https://doi.org/10.1158/1078-0432.22480715
Autor:
Bala Koritala, Yin Yeng Lee, Laetita S Gaspar, Josette Smith, Jiffin Paulose, Lauren Francey, Gang Wu, Marc Ruben, David Smith
Publikováno v:
SLEEP. 46:A5-A5
Introduction Intermittent hypoxia (IH) is a condition that occurs in people with obstructive sleep apnea (OSA), in which breathing is repeatedly interrupted during sleep. This can cause a lack of oxygen (hypoxia) in the body. OSA is associated with c
Autor:
Yin Yeng Lee, Mehari Endale, Gang Wu, Marc D Ruben, Lauren J Francey, Andrew R Morris, Natalie Y Choo, Ron C Anafi, David F Smith, Andrew C Liu, John B Hogenesch
Publikováno v:
Sleep.
Study Objectives Genetics impacts sleep, yet, the molecular mechanisms underlying sleep regulation remain elusive. In this study, we built machine learning models to predict sleep genes based on their similarity to genes that are known to regulate sl
Autor:
Rahul Nahar, Yin Yeng Lee, Alexis J. Khng, Tong Zhang, Angela Takano, Xingliang Liu, Jacob J.S. Alvarez, Ori Zelichov, Ezra Ella, Zohar Barbash, Chong Hee Lim, Tina P.T. Koh, Zaw Win Aung, Tony Kiat Hon Lim, Chee Keong Toh, Wan-Teck Lim, Bing Lim, Wai Leong Tam, Eng-Huat Tan, Weiwei Zhai, Daniel S.W. Tan, Axel M. Hillmer
Publikováno v:
Canadian Journal of Biotechnology, Vol 1, Iss Special Issue-Supplement, Pp 246-247 (2017)
While, the genomic landscape of early stage, treatment naïve lung adenocarcinomas (LUADs) has been described quite elaborately in recent literature, the genomic profile of late stage, drug resistant tumors remains largely unknown. Further, most of t
Externí odkaz:
https://doaj.org/article/c212bf3746934dea82e305653f18b2d6
Autor:
Yin Yeng Lee, Sibel Cal-Kayitmazbatir, Lauren J. Francey, Michael Seifu Bahiru, Katharina E. Hayer, Gang Wu, Molly J. Zeller, Robyn Roberts, James Speers, Justin Koshalek, Mark E. Berres, Eric L. Bittman, John B. Hogenesch
Publikováno v:
Proceedings of the National Academy of Sciences. 119
SignificanceWe successfully identified theduperallele as a null mutation of Cryptochrome 1 in Syrian hamsters. Here, we have shown the use of fast homozygosity mapping as an effective approach to identify causal mutations in mammals, despite lacking