Discovery of novel 1,2,4-triazine-chalcone hybrids as anti-gastric cancer agents via an axis of ROS-ERK-DR5 in vitro and in vivo

Autor: Chong Liu, Jian Song, Xin-Xin Cui, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Xin-Yi Tian, Ya-Feng Wang, Yang Liu, Sai-Yang Zhang

Publikováno v: Arabian Journal of Chemistry, Vol 15, Iss 3, Pp 103644- (2022)

In this work, a series of novel 1,2,4-triazine-chalcone hybrids were designed through the molecular hybridization strategy, synthesized by two step chlorinations and further aldol condensation and evaluated their antiproliferative activity against MG

Externí odkaz: https://doaj.org/article/3178ed9210dd4b6c8d738a9a4b82750a

Discovery of Novel Diarylamide N-Containing Heterocyclic Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity

Autor: Xu Liu, Xiao-Jing Pang, Yuan Liu, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Yan-Bing Zhang, Jian Song, Sai-Yang Zhang

Publikováno v: Molecules, Vol 26, Iss 13, p 4047 (2021)

Tubulin has been regarded as an attractive and successful molecular target in cancer therapy and drug discovery. Vicinal diaryl is a simple scaffold found in many colchicine site tubulin inhibitors, which is also an important pharmacophoric point of

Externí odkaz: https://doaj.org/article/dab30dc0e5ca44a2b3e3d4a153556412

Synthesis and Biological Evaluation of Amino Chalcone Derivatives as Antiproliferative Agents

Autor: Chao-Fan Lu, Sheng-Hui Wang, Xiao-Jing Pang, Ting Zhu, Hong-Li Li, Qing-Rong Li, Qian-Yu Li, Yu-Fan Gu, Zhao-Yang Mu, Min-Jie Jin, Yin-Ru Li, Yang-Yang Hu, Yan-Bing Zhang, Jian Song, Sai-Yang Zhang

Publikováno v: Molecules, Vol 25, Iss 23, p 5530 (2020)

Chalcone is a common scaffold found in many biologically active compounds. The chalcone scaffold was also frequently utilized to design novel anticancer agents with potent biological efficacy. Aiming to continue the research of effective chalcone der

Externí odkaz: https://doaj.org/article/e99955b3d1a64f949f7cdee869c622d4

Discovery of N-aryl sulphonamide-quinazoline derivatives as anti-gastric cancer agents in vitro and in vivo via activating the Hippo signalling pathway

Autor: Jian Song, Sai-Yang Zhang, Jin-Bo Niu, Chun-Quan Hua, Cheng-Yun Jin, Jia-Jia Yang, Yan-Bing Zhang, Guang-Xi Yu, Yuan Liu, Ying-Qiu Qi, Yin-Ru Li

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1715-1731 (2021)

Hippo signalling pathway plays a crucial role in tumorigenesis and cancer progression. In this work, we identified an N-aryl sulphonamide-quinazoline derivative, compound 9i as an anti-gastric cancer agent, which exhibited potent antiproliferative ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47daa120769670ada9991db4d05cac08
http://europepmc.org/articles/PMC8386742

A Novel Aromatic Amide Derivative SY-65 co-Targeting Tubulin and Histone Deacetylase 1 with Potent Anticancer Activity in Vitro and in Vivo

Autor: Jian Song, Fang-Fang Liu, Yin-Ru Li, Wen-Bo Liu, Guang-Xi Yu, Xin-Yi Tian, Yan-Bing Zhang, Sai-Yang Zhang

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb9a1ef1a7cf417c31079639fd9e1bc5
https://doi.org/10.2139/ssrn.4044224