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Dysregulated Rbfox2 produces aberrant splicing of CaV1.2 calcium channel in diabetes-induced cardiac hypertrophy.

Autor: Li, Pengpeng, Qin, Dongxia, Chen, Tiange, Hou, Wei, Song, Xinyu, Yin, Shumin, Song, Miaomiao, Fernando, W.C. Hewith A., Chen, Xiaojie, Sun, Yu, Wang, Juejin

Publikováno v: Cardiovascular Diabetology; 7/6/2023, Vol. 22 Issue 1, p1-16, 16p

Aberrant splicing of Ca V 1.2 calcium channel induced by decreased Rbfox1 enhances arterial constriction during diabetic hyperglycemia.

Autor: Hou W; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China.; The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, China., Yin S; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China., Li P; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China., Zhang L; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China., Chen T; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China., Qin D; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China., Mustafa AU; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China., Liu C; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China., Song M; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China., Qiu C; Nanjing Comprehensive Stroke Center, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China., Xiong X; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China. xqxiong@njmu.edu.cn.; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China. xqxiong@njmu.edu.cn.; The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, China. xqxiong@njmu.edu.cn., Wang J; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China. juejinwang@njmu.edu.cn.; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, China. juejinwang@njmu.edu.cn.; The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, China. juejinwang@njmu.edu.cn.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 Apr 04; Vol. 81 (1), pp. 164. Date of Electronic Publication: 2024 Apr 04.