Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

Autor: Miaomiao Li, Chih Yean Ong, Christophe J Langouët-Astrié, Lisi Tan, Ashwni Verma, Yimu Yang, Xiaoxiao Zhang, Dhaval K Shah, Eric P Schmidt, Ding Xu

Publikováno v: eLife, Vol 11 (2022)

RAGE, a druggable inflammatory receptor, is known to function as an oligomer but the exact oligomerization mechanism remains poorly understood. Previously we have shown that heparan sulfate (HS) plays an active role in RAGE oligomerization. To unders

Externí odkaz: https://doaj.org/article/fd4241c108454ee0ac24b569c2771b24

Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-α antibodies.

Autor: Rhea Bhargava, Christopher J Altmann, Ana Andres-Hernando, Ryan G Webb, Kayo Okamura, Yimu Yang, Sandor Falk, Eric P Schmidt, Sarah Faubel

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79037 (2013)

Acute kidney injury (AKI) and acute lung injury (ALI) are serious complications of sepsis. AKI is often viewed as a late complication of sepsis. Notably, the onset of AKI relative to ALI is unclear as routine measures of kidney function (BUN and crea

Externí odkaz: https://doaj.org/article/eac2a03b3da04a76b59219e8689773db

The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia

Autor: Christophe Langouët-Astrié, Kaori Oshima, Sarah A. McMurtry, Yimu Yang, Jakub M. Kwiecinski, Wells B. LaRivière, Jeffrey S. Kavanaugh, Igor Zakharevich, Kirk C. Hansen, Deling Shi, Fuming Zhang, Kristina M. Boguslawski, Sofya S. Perelman, Gouwei Su, Victor J. Torres, Jian Liu, Alexander R. Horswill, Eric P. Schmidt

Publikováno v: Cell reports. 41(9)

Influenza infection is substantially worsened by the onset of secondary pneumonia caused by bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). The bidirectional interaction between the influenza-injured lung microenvironment and MR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c76a3ec94ba78c8f0f826b3cebf8fa0
https://pubmed.ncbi.nlm.nih.gov/36450248

Author response: Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

Autor: Miaomiao Li, Chih Yean Ong, Christophe J Langouët-Astrié, Lisi Tan, Ashwni Verma, Yimu Yang, Xiaoxiao Zhang, Dhaval K Shah, Eric P Schmidt, Ding Xu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1e54c6c086845a2f6f70e078e90b07d
https://doi.org/10.7554/elife.71403.sa2

Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses

Autor: Fuming Zhang, Yimu Yang, Sarah A. McMurtry, Xinping Yue, Sarah M. Haeger, Yilan Ouyang, Eric P. Schmidt, Xiaorui Han, Trevor Lane, Pavel Davizon-Castillo, Robert J. Linhardt, Kaori Oshima, Rana El Masri, Romain R. Vivès

Publikováno v: Am J Physiol Lung Cell Mol Physiol
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2019, ⟨10.1152/ajplung.00175.2019⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2019, ⟨10.1152/ajplung.00175.2019⟩

International audience; 2019.-Sepsis patients are at increased risk for hospital-acquired pulmonary infections, potentially due to postseptic immunosuppression known as the compensatory anti-inflammatory response syndrome (CARS). CARS has been attrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa8a2c6e6090add0aa167a9763200ae
https://doi.org/10.1152/ajplung.00175.2019