Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yime Zhang"'
Autor:
Mengwei Han, Luni Hu, Di Wu, Yime Zhang, Peng Li, Xingyu Zhao, Yanyu Zeng, Guanqun Ren, Zhiyuan Hou, Yanli Pang, Tongbiao Zhao, Chao Zhong
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Tissue-resident Natural Killer (trNK) cells are crucial components of local immunity that activate rapidly upon infection. However, under steady state conditions, their responses are tightly controlled to prevent unwanted tissue damage. The
Externí odkaz:
https://doaj.org/article/01225778d4bf44779e5914bbb5405827
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Innate lymphoid cells (ILCs), as the innate counterpart of CD4+ T helper (Th) cells, play crucial roles in maintaining tissue homeostasis. While the ILC subsets and their corresponding Th subsets demonstrate significant similarities in core programmi
Externí odkaz:
https://doaj.org/article/6f5a81c978484140975edc510f5d9362
Autor:
Luni Hu, Mengwei Han, Yichen Deng, Jingjing Gong, Zhiyuan Hou, Yanyu Zeng, Yime Zhang, Jing He, Chao Zhong
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107187- (2023)
Summary: Tissue-residential natural killer (trNK) cells act as pioneering responders during infectious challenges. However, their discrimination with conventional NK (cNK) cells is still an issue. Through an integrative transcriptome comparison of th
Externí odkaz:
https://doaj.org/article/1f150adad3d44e86a32b568e966a4f7c
Autor:
Luni Hu, Xingyu Zhao, Peng Li, Yanyu Zeng, Yime Zhang, Yang Shen, Yukai Wang, Xiaolin Sun, Binbin Lai, Chao Zhong
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Pathogenic Th17, featured by their production of pro-inflammatory cytokines, are considered as a key player in most autoimmune diseases. The transcriptome of them is obviously distinct from that of conventional regulatory Th17. However, chromatin acc
Externí odkaz:
https://doaj.org/article/6f7a852895714fea8b2df784a6794580
Autor:
Xing Wang, Dedao Wang, Ning Ding, Lan Mi, Hui Yu, Meng Wu, Feier Feng, Luni Hu, Yime Zhang, Chao Zhong, Yingying Ye, Jiao Li, Wei Fang, Yunfei Shi, Lijuan Deng, Zhitao Ying, Yuqin Song, Jun Zhu
Publikováno v:
Cancers, Vol 13, Iss 17, p 4249 (2021)
Background: Upregulation of H3K27me3 induced by EZH2 overexpression or somatic heterozygous mutations were implicated in lymphomagenesis. It has been demonstrated that several EZH2-target agents have notable therapeutic effects in EZH2-mutant B-cell
Externí odkaz:
https://doaj.org/article/abf76223b51448c6a46187f92e80b406
Autor:
Di Wu, Luni Hu, Mengwei Han, Yichen Deng, Yime Zhang, Guanqun Ren, Xingyu Zhao, Zongxian Li, Peng Li, Yinlian Zhang, Shanwen Chen, Jun Li, Yanyan Shi, Jianxin Xue, Pengyuan Wang, Chao Zhong
Publikováno v:
Nature metabolism. 4(7)
Anti-programmed death-1 (PD-1) immunotherapy that aims to restore T cell activity in cancer patients frequently leads to immune-related adverse events such as colitis. However, the underlying mechanism is still elusive. Here, we find that Pdcd1-defic
Autor:
Zhitao Ying, Lijuan Deng, Hui Yu, Feier Feng, Jun Zhu, Luni Hu, Jiao Li, Lan Mi, Dedao Wang, Wei Fang, Chao Zhong, Meng Wu, Xing Wang, Yime Zhang, Yunfei Shi, Yuqin Song, Yingying Ye, Ning Ding
Publikováno v:
Cancers, Vol 13, Iss 4249, p 4249 (2021)
Cancers
Volume 13
Issue 17
Cancers
Volume 13
Issue 17
Simple Summary The EZH2-targeted drugs have demonstrated notable therapeutic effects in EZH2 mutant B-cell lymphoma patients. In this study, we demonstrated that the combination of EZH2 inhibitor SHR2554 and HDAC inhibitor HBI8000 exert synergistic a