Genetic variations in base excision repair pathway and risk of bladder cancer: A case–control study in the United States

Autor: Hui Xie, Jian Gu, Yilei Gong, Xifeng Wu, Jingyao Dai

Publikováno v: Molecular Carcinogenesis. 54:50-57

Base excision repair (BER) is one of the major cellular DNA repair pathways that repairs small isolated foci of DNA damage including reduced or oxidized single bases or fragments and small, non-bulky adducts. Genetic variations in BER genes may affec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9844f2d7df16e71261d36c63c82d4d03
https://doi.org/10.1002/mc.22073

Reduced mitochondrial DNA copy number in peripheral blood leukocytes increases the risk of soft tissue sarcoma

Autor: Xifeng Wu, Hui Xie, Dina Lev, Yilei Gong, Jian Gu, Raphael E. Pollock, Shui Wang

Publikováno v: Carcinogenesis. 34:1039-1043

Mitochondrial DNA (mtDNA) has increased susceptibility to damage due to its close proximity to the site of reactive oxygen species production, lack of introns and protective histones, and less efficient DNA repair mechanisms than nuclear DNA. The rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577f2ce3625f855b2309aae834f436a9
https://doi.org/10.1093/carcin/bgt023

Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry

Autor: Núria Malats, Robert L. Grubb, Jarmo Virtamo, William Wheeler, Zhaoming Wang, Françoise Clavel-Chapelon, Helena Furberg, Colin P.N. Dinney, Stephanie J. Weinstein, Josep Lloreta, Edward Giovannucci, Jan G. Hengstler, Katja K.H. Aben, Manolis Kogevinas, Simonetta Guarrera, Paul Brennan, Joseph Vijai, Alison Johnson, Paolo Vineis, Consol Serra, Mark P. Purdue, Peter Kraft, Vijayalakshmi Panduri, Morgan Rouprêt, Anne Tjønneland, Angela Carta, Geraldine Cancel-Tassin, Thorunn Rafnar, Marianna C. Stern, Molly Schwenn, Silvia Selinski, Giuseppe Matullo, H. Bas Bueno-de-Mesquita, Ruth C. Travis, Jennifer Prescott, Rebecca P. Jeppson, Stephen J. Chanock, Kvetoslava Koppova, David Van Den Berg, Stella Koutros, Amanda Black, Immaculata De Vivo, Stefano Porru, Jack A. Taylor, Laurie Burdett, Alfredo Carrato, Anne E. Kiltie, Timothy Bishop, Ludmila Prokunina-Olsson, Xia Pu, Charles Kooperberg, Reina García-Closas, Charles C. Chung, Cecilia Arici, Debra T. Silverman, W. Ryan Diver, Christopher A. Haiman, Eugene Gurzau, A. Rouf Banday, Amy Hutchinson, Mark Teo, Lambertus A. Kiemeney, Dalsu Baris, Kari Stefansson, Vittorio Krogh, Elio Riboli, Jose E. Castelao, Mark Harland, Victoria K. Cortessis, Chancellor Hohensee, Gerald L. Andriole, Demetrius Albanes, Margaret R. Karagas, Jonine D. Figueroa, Alan R. Schned, Joseph F. Fraumeni, Yilei Gong, Olivier Cussenot, Montserrat Garcia-Closas, Adonina Tardón, Manuela Gago-Dominguez, Simone Benhamou, Candace D. Middlebrooks, Patrick Sulem, Zongli Xu, Ashish M. Kamat, Giovanni Fiorito, Nilanjan Chatterjee, Tessel E. Galesloot, Sara Lindström, Eva Comperat, Kenneth Offit, Giuseppe Mastrangelo, Malcolm C. Pike, Ryan P. Kopp, Eric J. Jacobs, Holger Gerullis, G. M. Monawar Hosain, Gudmar Thorleifsson, Elisabete Weiderpass, Maria Elena Martinez, Constance Turman, Börje Ljungberg, David V. Conti, Patricia Cordeiro, Jenny Chang-Claude, David J. Hunter, Meinolf Blaszkewicz, Sita H. Vermeulen, Carlotta Sacerdote, Nathaniel Rothman, Xifeng Wu, Dean F. Bajorin, Jian-Min Yuan, Maria Teresa Landi, Susan M. Gapstur, Manuel Calaza, Sofia Pavanello, Yuanqing Ye, Tony Fletcher, Liren Zhang, Afshan Siddiq, Neil E. Caporaso, Miren Dorronsoro, Rajiv Kumar, Klaus Golka, Daniel Ovsiannikov

Publikováno v: Human Molecular Genetics, 25, 6, pp. 1203-14
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Human Molecular Genetics, 25, 1203-14

Contains fulltext : 167299.pdf (Publisher’s version ) (Closed access) Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk. In search for additional susceptibil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d272946c1c91cd31ee683c249f818cd7
http://hdl.handle.net/10044/1/43017

DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation

Autor: Yun Ling, Ying Sun, Bo Zhang, Yilei Gong, Haijing Liu, Lin Hou

Publikováno v: Molecular and Cellular Biochemistry. 300:249-258

NAT10 (N-acetyltransferase 10) is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity. The presented research shows its transcriptional activation by genotoxic agents and possible r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059ebfd887d031b5c0fbfbeffa164dad
https://doi.org/10.1007/s11010-006-9390-5

γ-H2AX level in peripheral blood lymphocytes as a risk predictor for bladder cancer

Autor: Jie Lin, Xifeng Wu, Yuanqing Ye, Mario I. Fernández, David W. Chang, Ashish M. Kamat, Yilei Gong

Identification of susceptibility to double-strand breaks (DSBs) may provide valuable information about individual bladder cancer (BC) risk. The formation of γ-H2AX foci is a highly sensitive marker for DNA DSBs induction. We assessed whether levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cdd5b6a3094b2ba450967c731f21fa
https://europepmc.org/articles/PMC3810842/