Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Yilai, Shu"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102207- (2024)
Externí odkaz:
https://doaj.org/article/98e9880015864b6bafb4d5b388f9ed48
Autor:
Hui Wang, MengZhao Xun, Honghai Tang, Jingjing Zhao, Shaowei Hu, Longlong Zhang, Jun Lv, Daqi Wang, Yuxin Chen, Jianping Liu, Geng-lin Li, Wuqing Wang, Yilai Shu, Huawei Li
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102135- (2024)
Adeno-associated viral (AAV) vectors are increasingly used as vehicles for gene delivery to treat hearing loss. However, lack of specificity of the transgene expression may lead to overexpression of the transgene in nontarget tissues. In this study,
Externí odkaz:
https://doaj.org/article/e8e4823512a44988bbfb0d4d69c3cdbb
Autor:
Jieyu Qi, Fangzhi Tan, Liyan Zhang, Ling Lu, Shanzhong Zhang, Yabo Zhai, Yicheng Lu, Xiaoyun Qian, WenXiu Dong, Yinyi Zhou, Ziyu Zhang, Xuehan Yang, Lulu Jiang, Chaorong Yu, Jiancheng Liu, Tian Chen, Lianqiu Wu, Chang Tan, Sijie Sun, Huaien Song, Yilai Shu, Lei Xu, Xia Gao, Huawei Li, Renjie Chai
Publikováno v:
Advanced Science, Vol 11, Iss 11, Pp n/a-n/a (2024)
Abstract Mutations in OTOFERLIN (OTOF) lead to the autosomal recessive deafness 9 (DFNB9). The efficacy of adeno‐associated virus (AAV)‐mediated OTOF gene replacement therapy is extensively validated in Otof‐deficient mice. However, the clinica
Externí odkaz:
https://doaj.org/article/13ae727fa26b405d86d815a31da8c0fe
Autor:
Yong Tao, Veronica Lamas, Wan Du, Wenliang Zhu, Yiran Li, Madelynn N. Whittaker, John A. Zuris, David B. Thompson, Arun Prabhu Rameshbabu, Yilai Shu, Xue Gao, Johnny H. Hu, Charles Pei, Wei-Jia Kong, Xuezhong Liu, Hao Wu, Benjamin P. Kleinstiver, David R. Liu, Zheng-Yi Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mutations in Atp2b2, an outer hair cell gene, cause dominant hearing loss in humans. Using a mouse model Atp2b2 Obl/+, with a dominant hearing loss mutation (Oblivion), we show that liposome-mediated in vivo delivery of CRISPR-Cas9 ribonucle
Externí odkaz:
https://doaj.org/article/a29936b8a683497cbbd1b953799336a4
Autor:
Shao Wei Hu, Jun Lv, Zijing Wang, Honghai Tang, Hui Wang, Fang Wang, Daqi Wang, Juan Zhang, Longlong Zhang, Qi Cao, Yuxin Chen, Ziwen Gao, Yu Han, Wuqing Wang, Geng-lin Li, Yilai Shu, Huawei Li
Publikováno v:
Research, Vol 7 (2024)
Adeno-associated virus (AAV)-mediated gene therapy is widely applied to treat numerous hereditary diseases in animal models and humans. The specific expression of AAV-delivered transgenes driven by cell type-specific promoters should further increase
Externí odkaz:
https://doaj.org/article/89a84e13996f4295b59370cfdeb239ce
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
Aminoglycosides are commonly used for the treatment of life-threatening bacterial infections, however, aminoglycosides may cause irreversible hearing loss with a long-term clinical therapy. The mechanism and prevention of the ototoxicity of aminoglyc
Externí odkaz:
https://doaj.org/article/91094f80d72a4c6c882ed986ebfb382a
Autor:
Longlong Zhang, Hui Wang, Mengzhao Xun, Honghai Tang, Jinghan Wang, Jun Lv, Biyun Zhu, Yuxin Chen, Daqi Wang, Shaowei Hu, Ziwen Gao, Jianping Liu, Zheng-Yi Chen, Bing Chen, Huawei Li, Yilai Shu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101154- (2023)
Pathogenic mutations in the OTOF gene cause autosomal recessive hearing loss (DFNB9), one of the most common forms of auditory neuropathy. There is no biological treatment for DFNB9. Here, we designed an OTOF gene therapy agent by dual-adeno-associat
Externí odkaz:
https://doaj.org/article/9201e8bb5dec4aaeb92965f6e0ea9271
Autor:
Qianying Liu, Xiang Zhang, Hui Huang, Yuxin Chen, Fang Wang, Aihua Hao, Wuqiang Zhan, Qiyu Mao, Yuxia Hu, Lin Han, Yifang Sun, Meng Zhang, Zhimin Liu, Geng-Lin Li, Weijia Zhang, Yilai Shu, Lei Sun, Zhenguo Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Pendrin (SLC26A4) is an anion exchanger expressed in the apical membranes of selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder associated with sensorineural hearing loss, hypothyroid goiter, and reduced blood p
Externí odkaz:
https://doaj.org/article/83e181bf026b4e51a03818fe885972ff
Autor:
Chong Cui, Daqi Wang, Bowei Huang, Fang Wang, Yuxin Chen, Jun Lv, Luping Zhang, Lei Han, Dong Liu, Zheng-Yi Chen, Geng-Lin Li, Huawei Li, Yilai Shu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 400-412 (2022)
Gene therapy would benefit from the effective editing of targeted cells with CRISPR-Cas9 tools. However, it is difficult to precisely assess the editing performance in vivo because the tissues contain many non-targeted cells, which is one of the majo
Externí odkaz:
https://doaj.org/article/00257e5ff9874d46b092959adb4ca12b
Autor:
Yangyang Yuan, Chenwei Wang, Xuran Zhuang, Shaofeng Lin, Miaomiao Luo, Wankun Deng, Jiaqi Zhou, Lihui Liu, Lina Mao, Wenbo Peng, Jian Chen, Qiangsong Wang, Yilai Shu, Yu Xue, Pengyu Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Protein kinase-mediated phosphorylation plays a critical role in many biological processes. Here the authors develop a trans-omics-based algorithm called Central Kinase Inference to integrate quantitative transcriptomic and phosphoproteomic data, fin
Externí odkaz:
https://doaj.org/article/0fc89203a49d4c89ba7a14014742a0a6