Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yike Ni"'
Autor:
Shijie Wei, Tianqi Du, Lili Zhang, Xuhao Li, Zhe Wang, Yike Ning, Yu Tang, Xinyu Wu, Jing Han
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-21 (2024)
Abstract Background Migraine, as a prevalent neurologic disorder, involves intricate and yet incompletely elucidated pathophysiological mechanisms. A plethora of research findings underscores the pivotal role played by astrocytes in the progression o
Externí odkaz:
https://doaj.org/article/f9ecc1eb198541639df66f2430c2bd9c
Autor:
Shijie Wei, Hao Lv, Dianhui Yang, Lili Zhang, Xuhao Li, Yike Ning, Yu Tang, Xinyu Wu, Jing Han
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundMigraine imposes a substantial global burden, impacting patients and society. Pharmacotherapy, as a primary treatment, entails specific adverse reactions. Emphasizing these reactions is pivotal for improving treatment strategies and enhanci
Externí odkaz:
https://doaj.org/article/01e28e54e30443d1bd151f10045ffb07
Publikováno v:
Entropy, Vol 26, Iss 7, p 579 (2024)
The rapid evolution of computer technology and social networks has led to massive data generation through interpersonal communications, necessitating improved methods for information mining and relational analysis in areas such as criminal activity.
Externí odkaz:
https://doaj.org/article/9c8f3a08a0d4498d946106dd5dd679fe
Autor:
Albert J. Robichaud, Norbert Hoefgen, Karen L. Marquis, Steven M. Grauer, Hans Stange, Radka Graf, Ute Egerland, Thorsten Hage, Christian Grunwald, Julie A. Brennan, Michael S. Malamas, Boyd L. Harrison, Menelas N. Pangalos, Kevin Parris, Thomas Kronbach, Yike Ni, Kristi Fan, Rudolf Schindler, Rachel Navarra, Hans-Joachim Lankau, Nicholas J. Brandon, James Joseph Erdei, Barbara Langen
Publikováno v:
Journal of Medicinal Chemistry. 54:7621-7638
The identification of highly potent and orally active phenylpyrazines for the inhibition of PDE10A is reported. The new analogues exhibit subnanomolar potency for PDE10A, demonstrate high selectivity against all other members of the PDE family, and s
Publikováno v:
Journal of the American Chemical Society. 131:17714-17718
A unified approach to the pyrrolidine triacid natural products isodomoic acids G and H has been developed. Total syntheses of both natural products were completed, and determination of the correct stereostructure of isodomoic acid G was established b
Autor:
John Montgomery, Yike Ni
Publikováno v:
Journal of the American Chemical Society. 128:2609-2614
A new nickel-catalyzed procedure for the [4+2+1] cycloaddition of (trimethylsilyl)diazomethane with alkynes tethered to dienes has been developed. A broad range of unsaturated substrates participates in the sequence, and stereoselectivities are gener
Autor:
Menelas N. Pangalos, James Joseph Erdei, Rudolf Schindler, Thorsten Hage, Christian Grunwald, Hans Stange, Michael S. Malamas, Julie A. Brennan, Barbara Langen, Nicholas J. Brandon, Norbert Hoefgen, Kristi Fan, Yike Ni, Boyd L. Harrison, Albert J. Robichaud, Karen L. Marquis, Radka Graf, Kevin Parris, Hans-Joachim Lankau, Steven M. Grauer, Rachel Navarra, Ute Egerland, Thomas Kronbach
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(18)
The identification of highly potent and orally active triazines for the inhibition of PDE10A is reported. The new analogs exhibit low-nanomolar potency for PDE10A, demonstrate high selectivity against all other members of the PDE family, and show des
Publikováno v:
Organic Letters. 4:1743-1745
[reaction: see text] 1,3-Dienes were prepared by a variety of nickel-catalyzed couplings and cyclization processes. Intermolecular or partially intramolecular couplings of alkynes, vinylzirconium reagents, and either aldehydes or enones efficiently p
Autor:
Lih-Ling Lin, Ariamala Gopalsamy, Derek C. Cole, J. Perry Hall, Manus Ipek, Rajiah Aldrin Denny, Yonghan Hu, Julie Liu, Yike Ni, Julie Lee, Jean-Baptiste Telliez, Michael Luong
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(19)
We report here the synthesis and SAR of a new series of thieno[3,2-d]pyrimidines as potent Tpl2 kinase inhibitors. The proposed binding mode suggests the potential flipped binding mode depending on the substitution. Biacore studies show evidence of b
Autor:
Yike Ni, Derek C. Cole, Rajiah Aldrin Denny, Julie Liu, David R. Anderson, Timothy Chamberlain, Yonghan Hu, Lih-Ling Lin, Manus Ipek, J. Perry Hall, Suvit Thaisrivongs, Michael Luong, Xiaolun Wang, Jean-Baptiste Telliez, Ariamala Gopalsamy
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(16)
Synthesis, modeling and structure–activity relationship of indazoles as inhibitors of Tpl2 kinase are described. From a high throughput screening effort, we identified an indazole hit compound 5 that has a single digit micromolar Tpl2 activity. Thr