Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yik-Lam Cho"'
Autor:
Wan Yun Ho, Li-Ling Chak, Jin-Hui Hor, Fujia Liu, Sandra Diaz-Garcia, Jer-Cherng Chang, Emma Sanford, Maria J. Rodriguez, Durgadevi Alagappan, Su Min Lim, Yik-Lam Cho, Yuji Shimizu, Alfred Xuyang Sun, Sheue-Houy Tyan, Edward Koo, Seung Hyun Kim, John Ravits, Shi-Yan Ng, Katsutomo Okamura, Shuo-Chien Ling
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108152- (2023)
Summary: MicroRNAs (miRNAs) modulate mRNA expression, and their deregulation contributes to various diseases including amyotrophic lateral sclerosis (ALS). As fused in sarcoma (FUS) is a causal gene for ALS and regulates biogenesis of miRNAs, we syst
Externí odkaz:
https://doaj.org/article/a1a36ec90cb447b39d91b7f4cf3e5ff6
Autor:
Hayden Weng Siong Tan, Guang Lu, Han Dong, Yik-Lam Cho, Auginia Natalia, Liming Wang, Charlene Chan, Dennis Kappei, Reshma Taneja, Shuo-Chien Ling, Huilin Shao, Shih-Yin Tsai, Wen-Xing Ding, Han-Ming Shen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The mechanisms underlying mitochondrial quality control are not fully understood. Here the authors identify a switch from degradative to secretory autophagy in the absence of the mATG8-conjugation system, termed Autophagic Secretion of Mitochondria.
Externí odkaz:
https://doaj.org/article/5faa98dd54e74eb38a71aec60636557b
Autor:
Heng Boon Low, Zhen Lim Wong, Bangyuan Wu, Li Ren Kong, Chin Wen Png, Yik-Lam Cho, Chun-Wei Li, Fengchun Xiao, Xuan Xin, Henry Yang, Jia Min Loo, Fiona Yi Xin Lee, Iain Bee Huat Tan, Ramanuj DasGupta, Han-Ming Shen, Herbert Schwarz, Nicholas R. J. Gascoigne, Boon Cher Goh, Xiaohong Xu, Yongliang Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Chemoresistance is one of the main challenges for cancer therapy success. Here, the authors show that dual-specificity phosphatase 16 (DUSP16) expression is associated with chemoresistance in several types of cancer through impairing mitochondria-ass
Externí odkaz:
https://doaj.org/article/7cd1e1ed821d475f86d18b8927eabe0d
Autor:
Yongliang Zhang, Heng Boon Low, Yik-Lam Cho, Herbert Schwarz, Nicholas R. J. Gascoigne, Fengchun Xiao, Chin Wen Png, Fiona Yi Xin Lee, Xiaohong Xu, Bangyuan Wu, Jia Min Loo, Han-Ming Shen, Li Ren Kong, Henry Yang, Ramanuj DasGupta, Zhen Lim Wong, Xuan Xin, Chun-Wei Li, Boon Cher Goh, Iain Beehuat Tan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Drug resistance is a major obstacle to the treatment of most human tumors. In this study, we find that dual-specificity phosphatase 16 (DUSP16) regulates resistance to chemotherapy in nasopharyngeal carcinoma, colorectal cancer, gastric and breast ca
Autor:
Hayden Weng Siong Tan, Guang Lu, Han Dong, Yik-Lam Cho, Auginia Natalia, Liming Wang, Charlene Chan, Dennis Kappei, Reshma Taneja, Shuo-Chien Ling, Huilin Shao, Shih-Yin Tsai, Wen-Xing Ding, Han-Ming Shen
Publikováno v:
Nature communications. 13(1)
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the most important mechanisms in mitochondrial quality control (MQC) via the clearance of damaged mitochondria. Although it is well known that the conjugation of mammal
Autor:
Rizwan Wahab, Yik-Lam Cho, Weifeng He, Han-Ming Shen, Javed Ahmad, Quaiser Saquib, Yi Ren, Boon-Huat Bay, Hayden Weng Siong Tan
Publikováno v:
Free radical biologymedicine. 153
Nickel oxide nanoparticles (NiO-NPs) are an important group of nanoparticles with increasing applications in many aspects of industry. At present, there is evidence demonstrating the cytotoxic characteristics of NiO-NPs, while the involvement of auto
Autor:
Yih-Cherng Liou, Yin Shi, Hanry Yu, Jianbin Zhang, Han-Ming Shen, Shuo Deng, Liming Wang, Yik-Lam Cho, Guang Lu, Pornteera Pawijit, Boon-Huat Bay, Kah-Leong Lim, Hayden Weng-Siong Tan, Jingzi Zhang, Yajun Wu, Yihua Wu, Jigang Wang, Yancheng Tang, Celestial T. Yap, Yan Tong, Lei Fang, Hui-Ying Chan, Grace Gui-Yin Lim, Mallilankaraman Karthik, Jung Eun Park, Ritu Chawla, Siu Kwan Sze, Chunxin Wang
Publikováno v:
Cell Research
Mitophagy is an important type of selective autophagy for specific elimination of damaged mitochondria. PTEN-induced putative kinase protein 1 (PINK1)-catalyzed phosphorylation of ubiquitin (Ub) plays a critical role in the onset of PINK1–Parkin-me