Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yik Siu"'
Autor:
Dominique F Leitner, Evgeny Kanshin, Manor Askenazi, Yik Siu, Daniel Friedman, Sasha Devore, Drew Jones, Beatrix Ueberheide, Thomas Wisniewski, Orrin Devinsky
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268597 (2022)
BackgroundTuberous sclerosis complex (TSC) and some focal cortical dysplasias (FCDs) are associated with dysfunctional mTOR signaling, resulting in increased cell growth and ribosomal S6 protein phosphorylation (phospho-S6). mTOR inhibitors can reduc
Externí odkaz:
https://doaj.org/article/1a1d5a20c92d4290b33bce6553d176bf
Publikováno v:
Viruses, Vol 15, Iss 1, p 242 (2023)
Influenza represents a major and ongoing public health hazard. Current collaborative efforts are aimed toward creating a universal flu vaccine with the goals of both improving responses to vaccination and increasing the breadth of protection against
Externí odkaz:
https://doaj.org/article/1819d34de0f74dc89203147f80914591
Autor:
Kim, Yubin, Park, Chanwoo, Jeong, Hyewon, Chan, Yik Siu, Xu, Xuhai, McDuff, Daniel, Lee, Hyeonhoon, Ghassemi, Marzyeh, Breazeal, Cynthia, Park, Hae Won
Foundation models are becoming valuable tools in medicine. Yet despite their promise, the best way to leverage Large Language Models (LLMs) in complex medical tasks remains an open question. We introduce a novel multi-agent framework, named Medical D
Externí odkaz:
http://arxiv.org/abs/2404.15155
Autor:
Dominique F. Leitner, Yik Siu, Aryeh Korman, Ziyan Lin, Evgeny Kanshin, Daniel Friedman, Sasha Devore, Beatrix Ueberheide, Aristotelis Tsirigos, Drew R. Jones, Thomas Wisniewski, Orrin Devinsky
Publikováno v:
Epilepsia. 64:1046-1060
Autor:
Jiehui Deng, David H. Peng, David Fenyo, Hao Yuan, Alfonso Lopez, Daniel S. Levin, Mary Meynardie, Mari Quinteros, Michela Ranieri, Soumyadip Sahu, Sally C. M. Lau, Elaine Shum, Vamsidhar Velcheti, Salman R. Punekar, Natasha Rekhtman, Catríona M. Dowling, Vajira Weerasekara, Yun Xue, Hongbin Ji, Yik Siu, Drew Jones, Aaron N. Hata, Takeshi Shimamura, John T. Poirier, Charles M Rudin, Takamitsu Hattori, Shohei Koide, Thales Papagiannakopoulos, Benjamin G. Neel, Nabeel Bardeesy, Kwok-kin Wong
Publikováno v:
bioRxiv
LKB1/STK11 is a serine/threonine kinase that plays a major role in controlling cell metabolism, resulting in potential therapeutic vulnerabilities in LKB1-mutant cancers. Here, we identify the NAD+degrading ectoenzyme, CD38, as a new target in LKB1-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664879e61c343e2d903f560a28e6eb38
https://europepmc.org/articles/PMC10153147/
https://europepmc.org/articles/PMC10153147/
Autor:
Drew R. Jones, Adrianna C. Shembel, Yik Siu, Leonard J. Ash, Tenzin Lhakhang, Aaron M. Johnson
Publikováno v:
Ann Otol Rhinol Laryngol
Objectives: (1) Determine the feasibility of obtaining a global, unbiased metabolomic profile on laryngeal muscle in a rat model; (2) evaluate the impact of biological aging on the laryngeal metabolome; and (3) characterize biochemical expression dif
Autor:
Francesco Boccalatte, Giacomo Milletti, Arnaldo A. Arbini, Sarah Keegan, Yeon-Tae Jeong, Francesco Cecconi, Sorasicha Nithikasem, Luca Busino, Francesca Nazio, Yik Siu, Gergely Róna, Nan Zhou, Emiliano Maiani, Alfie O’sullivan, Michele Pagano, Daniele Simoneschi, Andrew A. Wang, Drew R. Jones, David Fenyö, Shaowen Jiang, Valentina Cianfanelli
D-type cyclins are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer1, but the mechanisms that regulate their turnover are still being debated2,3. Here, by combining bioche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ac7a65f3511af731ad8b54caf76cf7
http://hdl.handle.net/2108/303777
http://hdl.handle.net/2108/303777
Autor:
Daniele, Simoneschi, Gergely, Rona, Nan, Zhou, Yeon-Tae, Jeong, Shaowen, Jiang, Giacomo, Milletti, Arnaldo A, Arbini, Alfie, O'Sullivan, Andrew A, Wang, Sorasicha, Nithikasem, Sarah, Keegan, Yik, Siu, Valentina, Cianfanelli, Emiliano, Maiani, Francesca, Nazio, Francesco, Cecconi, Francesco, Boccalatte, David, Fenyö, Drew R, Jones, Luca, Busino, Michele, Pagano
Publikováno v:
Nature
D-type cyclins are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer(1), but the mechanisms that regulate their turnover are still being debated(2,3). Here, by combining bi
Publikováno v:
ACS Synthetic Biology. 7:16-23
Feedback control allows cells to dynamically sense and respond to environmental changes. However, synthetic controller designs can be challenging because of implementation issues, such as determining optimal expression levels for circuit components w
Autor:
Marion Ferren, Negar Makhsous, Thomas Briese, Bert K. Rima, Matteo Porotto, Alexander L. Greninger, Yik Siu, Ya-Wen Chen, Anne Moscona, Hans-Willem Snoeck
Publikováno v:
Porotto, M, Ferren, M, Chen, Y-W, Siu, Y, Makhsous, N, Rima, B, Briese, T, Greninger, A L, Snoeck, H-W & Moscona, A 2019, ' Authentic Modeling of Human Respiratory Virus Infection in Human Pluripotent Stem Cell-Derived Lung Organoids ', mBio, vol. 10, no. 3, e00723-19 . https://doi.org/10.1128/mbio.00723-19
mBio, Vol 10, Iss 3 (2019)
mBio
mBio, Vol 10, Iss 3, p e00723-19 (2019)
mBio, Vol 10, Iss 3 (2019)
mBio
mBio, Vol 10, Iss 3, p e00723-19 (2019)
Respiratory viruses are among the first pathogens encountered by young children, and the significant impact of these viral infections on the developing lung is poorly understood. Circulating viruses are suited to the environment of the human lung and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202c48fcc5fcc5da7543a1a04693ba17
http://hdl.handle.net/11591/409188
http://hdl.handle.net/11591/409188