Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Yik A, Yeung"'
5
Akademický článek
One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics
Autor: Wei Chen, Fan Yang, Carole Wang, Jatin Narula, Edward Pascua, Irene Ni, Sheng Ding, Xiaodi Deng, Matthew Ling-Hon Chu, Amber Pham, Xiaoyue Jiang, Kevin C. Lindquist, Patrick J. Doonan, Tom Van Blarcom, Yik Andy Yeung, Javier Chaparro-Riggers
Publikováno v: mAbs, Vol 13, Iss 1 (2021)
T-cell engaging biologics is a class of novel and promising immune-oncology compounds that leverage the immune system to eradicate cancer. Here, we compared and contrasted a bispecific diabody-Fc format, which displays a relatively short antigen-bind
Externí odkaz: https://doaj.org/article/689b1a83bc0d495ead97d93c01362efb
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6
Akademický článek
FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells
Autor: Jie Wei, Shahram Salek-Ardakani, Wenjing Yang, Lucia Campos Carrascosa, Adriaan A van Beek, Valeska de Ruiter, Michail Doukas, Timothy S Fisher, Keith Ching, Karlijn van Loon, Patrick P C Boor, Yannick S Rakké, Lisanne Noordam, Pascal Doornebosch, Dirk Grünhagen, Kees Verhoef, Wojciech G Polak, Jan N M IJzermans, Irene Ni, Yik Andy Yeung, Dave Sprengers, Jaap Kwekkeboom
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background OX40 (CD134) is a costimulatory molecule of the tumor necrosis factor receptor superfamily that is currently being investigated as a target for cancer immunotherapy. However, despite promising results in murine tumor models, the clinical e
Externí odkaz: https://doaj.org/article/e56e3eb9973e485888dbd8bd5af2b0dc
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7
Akademický článek
Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
Autor: S. Michael Chin, Christopher R. Kimberlin, Zygy Roe-Zurz, Pamela Zhang, Allison Xu, Sindy Liao-Chan, Debasish Sen, Andrew R. Nager, Nicole Schirle Oakdale, Colleen Brown, Feng Wang, Yuting Yang, Kevin Lindquist, Yik Andy Yeung, Shahram Salek-Ardakani, Javier Chaparro-Riggers
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The costimulatory T-cell receptor 4-1BB is an immuno-oncology target. Here the authors present the ligand bound 4-1BB receptor crystal structure in addition to the structures of 4-1BB bound with two therapeutic antibodies and verify the antibody bind
Externí odkaz: https://doaj.org/article/11f466e447544959a4ac278b485a238c
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8
Akademický článek
Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity
Autor: Pamela Zhang, Guang Huan Tu, Jie Wei, Pamela Santiago, Lance R. Larrabee, Sindy Liao-Chan, Tina Mistry, Matthew Ling-Hon Chu, Tao Sai, Kevin Lindquist, Hua Long, Javier Chaparro-Riggers, Shahram Salek-Ardakani, Yik Andy Yeung
Publikováno v: Cell Reports, Vol 27, Iss 11, Pp 3117-3123.e5 (2019)
Summary: Agonistic antibodies targeting the tumor necrosis factor (TNF) superfamily of co-stimulatory receptors (TNFRSF) are progressing through various stages of clinical development for cancer treatment, but the desired and defining features of the
Externí odkaz: https://doaj.org/article/44cb539f22be4485ababb5654bc38b0f
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