Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yijun Carrier"'
Autor:
Howard L. Weiner, Dennis J. Selkoe, Shaomin Li, Lior Mayo, Thomas Koeglsperger, Christian Brenneis, Yijun Carrier, Jessica L. Saulnier
Publikováno v:
Glia. 61:985-1002
Transforming growth factor β1 (TGF-β1) is a pleiotropic cytokine expressed throughout the CNS. Previous studies demonstrated that TGF-β1 contributes to maintain neuronal survival, but mechanistically this effect is not well understood. We generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece3931c29ac54981e2366429b6c388b
https://doi.org/10.1002/glia.22490
https://doi.org/10.1002/glia.22490
Autor:
Quintus G. Medley, Joe Craft, Heath Guay, Mayra Senices, Deborah Herber, Sarah A. Bertino, Sean Keegan, Tatyana A. Duzanski, Andrew L. Rankin, Nancy Stedman, Mark Ryan, Deborah Young, Laird Bloom, Kyri Dunussi-Joannopoulos, Yijun Carrier, Cheryl Nickerson-Nutter, Mary Collins
Publikováno v:
The Journal of Immunology. 188:1656-1667
MRL/MpJ-Faslpr/lpr/J (MRLlpr) mice develop lupus-like disease manifestations in an IL-21–dependent manner. IL-21 is a pleiotropic cytokine that can influence the activation, differentiation, and expansion of B and T cell effector subsets. Notably,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc891d5ac5598c935fe31180e731710d
https://doi.org/10.4049/jimmunol.1003871
https://doi.org/10.4049/jimmunol.1003871
Autor:
Yijun Carrier, Mary Collins, Margot O'Toole, Quintus G. Medley, Lynette A. Fouser, Kyri Dunussi-Joannopoulos, Hilda E. Ramon, Cheryl Nickerson-Nutter, Hak-Ling Ma, Lee Napierata, Clayton Small, Deborah A. Young
Publikováno v:
Journal of Investigative Dermatology. 131(12):2428-2437
Accumulating evidence indicates that IL-1 family members and Th17 cytokines have a pathogenic role in psoriasis. We investigated the regulatory interactions of the IL-1-like IL-36 cytokine family and the Th17 cytokines in the context of skin inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffd576762355c99511c21f53102729d
Autor:
Lynette A. Fouser, Scott H. Schelling, Andre-Jean Lambert, Kyriaki Dunussi-Joannopoulos, Quintus G. Medley, Hak-Ling Ma, Cheryl Nickerson-Nutter, Debra G. Goodwin, Kathleen Shields, Debra D. Pittman, Yijun Carrier, Mary Collins, Spencer Liang
Publikováno v:
The Journal of Immunology. 185:5531-5538
IL-22 is made by a unique set of innate and adaptive immune cells, including the recently identified noncytolytic NK, lymphoid tissue-inducer, Th17, and Th22 cells. The direct effects of IL-22 are restricted to nonhematopoietic cells, its receptor ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2455eb8047b810dd20814ab7b68bb83
https://doi.org/10.4049/jimmunol.0904091
https://doi.org/10.4049/jimmunol.0904091
Autor:
Howard L. Weiner, Muhamed Hadzipasic, Sharmila Masli, Yijun Carrier, Jose L. Vega, Luiz Vicente Rizzo, Jean Pierre Schatzmann Peron, Kaiyong Yang, Bing Zhu
Publikováno v:
Journal of Autoimmunity. 32:94-103
Transforming growth factor beta (TGF-beta) plays a role both in the induction of Treg and in the differentiation of the IL-17-secreting T cells (Th17) which drive inflammation in experimental autoimmune encephalomyelitis (EAE). We investigated the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909fc747119ae3a200e101c4b62b9e51
https://doi.org/10.1016/j.jaut.2008.12.004
https://doi.org/10.1016/j.jaut.2008.12.004
Autor:
Howard L. Weiner, Amit Awasthi, Yijun Carrier, Jean Pierre Schatzmann Peron, Estelle Bettelli, Mohamed Oukka, Vijay K. Kuchroo, Masahito Kamanaka, Richard A. Flavell
Publikováno v:
Nature Immunology. 8:1380-1389
Regulatory T cells (T(reg) cells) expressing the transcription factor Foxp3 are key in maintaining the balance of immune homeostasis. However, distinct induced T regulatory type 1 (Tr1) cells that lack Foxp3 expression also regulate T cell function,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e868667d6cd2d1bf41dfd81c5c874c2
https://doi.org/10.1038/ni1541
https://doi.org/10.1038/ni1541
Autor:
Wenda Gao, Terry B. Strom, Howard L. Weiner, Vijay K. Kuchroo, Yijun Carrier, Estelle Bettelli, Thomas Korn, Mohamed Oukka
Publikováno v:
Nature. 441:235-238
On activation, T cells undergo distinct developmental pathways, attaining specialized properties and effector functions. T-helper (T(H)) cells are traditionally thought to differentiate into T(H)1 and T(H)2 cell subsets. T(H)1 cells are necessary to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::def7bf7b57fbbfcd069a846e04f7ede9
https://doi.org/10.1038/nature04753
https://doi.org/10.1038/nature04753
Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells
Autor:
Joy S. Miyashiro, Stephen E. Benoit, Sean Keegan, Matthew J. Whitters, Hilda E. Ramon, Mark Ryan, Heath Guay, John Douhan, Mary Collins, Kyri Dunussi-Joannopoulos, Timothy P. LaBranche, Yijun Carrier, Quintus G. Medley
Publikováno v:
European journal of immunology. 42(6)
The glucocorticoid-induced TNFR-related (GITR) protein is a coactivating receptor that is constitutively expressed on Treg cells and induced on activated T cells. To better under-stand the role of long-term GITR signaling, we generated a mouse that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabb49f3804c8e88f0469534d7d0da17
https://pubmed.ncbi.nlm.nih.gov/22678896
https://pubmed.ncbi.nlm.nih.gov/22678896
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(1)
TGF-β has been shown to be critical in the generation of CD4+CD25+Foxp3+ regulatory T cells (Tregs). Because Th3 cells produce large amounts of TGF-β, we asked whether induction of Th3 cells in the periphery was a mechanism by which CD4+CD25+ Tregs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4248b5c444beee9037aea9cfdd88e059
https://pubmed.ncbi.nlm.nih.gov/17182553
https://pubmed.ncbi.nlm.nih.gov/17182553
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(1)
We developed a transgenic (Tg) mouse that expresses TGF-β under control of the IL-2 promoter to investigate Th3 cell differentiation both in vitro and in vivo. We previously found that repetitive in vitro Ag stimulation results in constant expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41772468e8530b439faee30205c589d2
https://pubmed.ncbi.nlm.nih.gov/17182552
https://pubmed.ncbi.nlm.nih.gov/17182552