Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Yijuang Chern"'
Autor:
Yu-Ju Liu, Chia-Wei Lee, Yi-Chu Liao, Joseph Jen-Tse Huang, Hung-Chih Kuo, Kang-Yang Jih, Yi-Chung Lee, Yijuang Chern
Publikováno v:
Neurobiology of Disease, Vol 202, Iss , Pp 106715- (2024)
Hypermetabolism is a prominent characteristic of ALS patients. Aberrant activation of AMPK, an energy sensor regulated by adiponectin, is known to cause TDP-43 mislocalization, an early event in ALS pathogenesis. This study aims to evaluate the assoc
Externí odkaz:
https://doaj.org/article/c59dd19c6624414084bc7bcefe65906f
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106672- (2024)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutant huntingtin protein with an abnormal CAG/polyQ expansion in the N-terminus of HTT exon 1. HD is characterized by progressive neurodegeneration and metabol
Externí odkaz:
https://doaj.org/article/aea99a4fd40047b0b5414155e0f1db5f
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2024)
IntroductionPathophysiological etiology of schizophrenia remains unclear due to the heterogeneous nature of its biological and clinical manifestations. Dysfunctional communication among large-scale brain networks and hub nodes have been reported. In
Externí odkaz:
https://doaj.org/article/a6af4646148f4e72a98702c87aada6c2
Autor:
Ching-Ya Chen, Fang-Yi Chou, Ya-Gin Chang, Chin-Jui Ho, Kuo-Chen Wu, Chia-Lin Hsu, Yijuang Chern, Chun-Jung Lin
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 106004- (2023)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease, characterized by motor dysfunction and abnormal energy metabolism. Equilibrative nucleoside transporter 1 (ENT1) and ENT2 are the major nucleoside transporters in cellular
Externí odkaz:
https://doaj.org/article/6f15d9764cfb43ce9c6011c5655438d2
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-25 (2021)
Abstract In modern societies, with an increase in the older population, age-related neurodegenerative diseases have progressively become greater socioeconomic burdens. To date, despite the tremendous effort devoted to understanding neurodegenerative
Externí odkaz:
https://doaj.org/article/7a4488a5dd2743c1a2546ca3cdf7573b
Autor:
Ching-Pang Chang, Ya-Gin Chang, Pei-Yun Chuang, Thi Ngoc Anh Nguyen, Kuo-Chen Wu, Fang-Yi Chou, Sin-Jhong Cheng, Hui-Mei Chen, Lee-Way Jin, Kevin Carvalho, Vincent Huin, Luc Buée, Yung-Feng Liao, Chun-Jung Lin, David Blum, Yijuang Chern
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including Alzheimer’s disease (AD). Earlier reports showed that adenosine metabolism is abnormal in the brain of AD patients whil
Externí odkaz:
https://doaj.org/article/8e4c10b7573a4385835d8307e2cb35af
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3443 (2023)
MicroRNAs (miRNAs) are 22-nucleotide noncoding RNAs involved in the differentiation, development, and function of cells in the body by targeting the 3′- untranslated regions (UTR) of mRNAs for degradation or translational inhibition. miRNAs not onl
Externí odkaz:
https://doaj.org/article/45d9e188fd394528a886ccdf00dbaa79
Publikováno v:
Neurobiology of Disease, Vol 160, Iss , Pp 105531- (2021)
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusi
Externí odkaz:
https://doaj.org/article/52a7d3f8cf4a4ab29473f8dcf59123f4
Autor:
Yu-Ju Liu, Yijuang Chern
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Impaired energy homeostasis and aberrant translational control have independently been implicated in the pathogenesis of neurodegenerative diseases. AMP kinase (AMPK), regulated by the ratio of cellular AMP and ATP, is a major gatekeeper for cellular
Externí odkaz:
https://doaj.org/article/b69e2203227f4f2a8b558b16bd846358
Autor:
Jian Jing Siew, Hui-Mei Chen, Huan-Yuan Chen, Hung-Lin Chen, Chiung-Mei Chen, Bing-Wen Soong, Yih-Ru Wu, Ching-Pang Chang, Yi-Chen Chan, Chun-Hung Lin, Fu-Tong Liu, Yijuang Chern
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
The authors show that Galectin-3 is up–regulated in brain tissues from patients and a mouse model of Huntington’s disease (HD) and correlates with disease severity. Galectin-3 accumulates at damaged lysosomes in HD microglia, prevents the clearan
Externí odkaz:
https://doaj.org/article/a6e1aa100a154ae9b970e162e6e98c2c