Zobrazeno 1 - 10
of 323
pro vyhledávání: '"Yijie Ding"'
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Drug-drug interactions (DDIs) can result in unexpected pharmacological outcomes, including adverse drug events, which are crucial for drug discovery. Graph neural networks have substantially advanced our ability to model molecular
Externí odkaz:
https://doaj.org/article/ab31b89159da4698b7343802f725e9f6
Publikováno v:
Fundamental Research, Vol 4, Iss 4, Pp 715-737 (2024)
Drug discovery is costly and time consuming, and modern drug discovery endeavors are progressively reliant on computational methodologies, aiming to mitigate temporal and financial expenditures associated with the process. In particular, the time req
Externí odkaz:
https://doaj.org/article/abe1d527aa9d49e99689609b6ec50f03
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionSi-Ni-San (SNS), a traditional Chinese medicine, is effective in treating liver fibrosis with an unclear mechanism. Although disturbance of intestinal flora and the subsequent secretion of short-chain fatty acids (SCFAs) is suggested to b
Externí odkaz:
https://doaj.org/article/3ea696a3fd7b44ac8a26174c3d4a29e5
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 8, p e1012339 (2024)
Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool in genomics research, enabling the analysis of gene expression at the individual cell level. However, scRNA-seq data often suffer from a high rate of dropouts, where certain genes
Externí odkaz:
https://doaj.org/article/02da9efc673d43f3bea64d12888e1cec
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1012229 (2024)
De novo drug design is crucial in advancing drug discovery, which aims to generate new drugs with specific pharmacological properties. Recently, deep generative models have achieved inspiring progress in generating drug-like compounds. However, the m
Externí odkaz:
https://doaj.org/article/49f1967bc5054099a4d4ebf1d7bd61ee
Publikováno v:
Mathematical Biosciences and Engineering, Vol 20, Iss 7, Pp 13149-13170 (2023)
DNA-binding proteins (DBPs) play a critical role in the development of drugs for treating genetic diseases and in DNA biology research. It is essential for predicting DNA-binding proteins more accurately and efficiently. In this paper, a Laplacian Lo
Externí odkaz:
https://doaj.org/article/dbc1cea8e5e5400784f34091b2a81b2f
Autor:
Yijie Ding, Fanglei Zhong
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
It is widely recognized that inequalities in social status cause inequalities in health. Women in a family often directly influence three generations–women themselves, their children and their parents -yet the effect of women’s family status on t
Externí odkaz:
https://doaj.org/article/dd33494e75e24dd68cf2ac43c708e53e
Publikováno v:
Mathematical Biosciences and Engineering, Vol 19, Iss 12, Pp 13829-13850 (2022)
Biological sequence analysis is an important basic research work in the field of bioinformatics. With the explosive growth of data, machine learning methods play an increasingly important role in biological sequence analysis. By constructing a classi
Externí odkaz:
https://doaj.org/article/e5edf62019494d7fb4384055a021070e
Autor:
Jun Yan, Tengsheng Jiang, Junkai Liu, Yaoyao Lu, Shixuan Guan, Haiou Li, Hongjie Wu, Yijie Ding
Publikováno v:
Mathematical Biosciences and Engineering, Vol 19, Iss 8, Pp 7719-7736 (2022)
The study of DNA binding proteins (DBPs) is of great importance in the biomedical field and plays a key role in this field. At present, many researchers are working on the prediction and detection of DBPs. Traditional DBP prediction mainly uses machi
Externí odkaz:
https://doaj.org/article/c2ad5b7c728a48aaa527a93b82e56cf5
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: The physical interactions between enhancers and promoters are often involved in gene transcriptional regulation. High tissue-specific enhancer-promoter interactions (EPIs) are responsible for the differential expression of genes. Experi
Externí odkaz:
https://doaj.org/article/5fda1721957641a88757f258bc4dfff5