Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Yijen L. Wu"'
Autor:
Jessica Cummings, Yijen L. Wu, C. Edward Dixon, Jeremy Henchir, J. Marc Simard, Ashok Panigrahy, Patrick M. Kochanek, Ruchira M. Jha, Rajesh K. Aneja
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-11 (2023)
Abstract Sepsis-associated brain injury (SABI) is characterized by an acute deterioration of mental status resulting in cognitive impairment and acquisition of new and persistent functional limitations in sepsis survivors. Previously, we reported tha
Externí odkaz:
https://doaj.org/article/09fef268cec240d990a9cc47f2ca7af1
Autor:
George C. Gabriel, William A. Devine, Bethany K. Redel, Kristin M. Whitworth, Melissa Samuel, Lee D. Spate, Raissa F. Cecil, Randall S. Prather, Yijen L. Wu, Kevin D. Wells, Cecilia W. Lo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The pig is an ideal model system for studying human development and disease due to its similarities to human anatomy, physiology, size, and genome. Further, advances in CRISPR gene editing have made genetically engineered pigs viable models
Externí odkaz:
https://doaj.org/article/93f422a95d7043129581d1f40224dc7b
Autor:
Nolan T. Carew, Heidi M. Schmidt, Shuai Yuan, Joseph C. Galley, Robert Hall, Helene M. Altmann, Scott A. Hahn, Megan P. Miller, Katherine C. Wood, Bethann Gabris, Margaret C. Stapleton, Sean Hartwick, Marco Fazzari, Yijen L. Wu, Mohamed Trebak, Brett A. Kaufman, Charles F. McTiernan, Francisco J. Schopfer, Placido Navas, Patrick H. Thibodeau, Dennis M. McNamara, Guy Salama, Adam C. Straub
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Sudden cardiac death (SCD) in patients with heart failure (HF) is allied with an imbalance in reduction and oxidation (redox) signaling in cardiomyocytes; however, the basic pathways and mechanisms governing redox homeostasis in cardiomyocytes are no
Externí odkaz:
https://doaj.org/article/347f7b78e498476bb1cd8f897c890698
Autor:
Erik A. Koppes, Bethany K. Redel, Marie A. Johnson, Kristen J. Skvorak, Lina Ghaloul-Gonzalez, Megan E. Yates, Dale W. Lewis, Susanne M. Gollin, Yijen L. Wu, Shawn E. Christ, Martine Yerle, Angela Leshinski, Lee D. Spate, Joshua A. Benne, Stephanie L. Murphy, Melissa S. Samuel, Eric M. Walters, Sarah A. Hansen, Kevin D. Wells, Uta Lichter-Konecki, Robert A. Wagner, Joseph T. Newsome, Steven F. Dobrowolski, Jerry Vockley, Randall S. Prather, Robert D. Nicholls
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Phenylalanine hydroxylase–deficient (PAH-deficient) phenylketonuria (PKU) results in systemic hyperphenylalaninemia, leading to neurotoxicity with severe developmental disabilities. Dietary phenylalanine (Phe) restriction prevents the most deleteri
Externí odkaz:
https://doaj.org/article/25a4c7bc5404441d96bc2b097f4c68db
Autor:
Maliha Zahid, Kyle S. Feldman, Gabriel Garcia-Borrero, Timothy N. Feinstein, Nicholas Pogodzinski, Xinxiu Xu, Raymond Yurko, Michael Czachowski, Yijen L. Wu, Neale S. Mason, Cecilia W. Lo
Publikováno v:
Biomolecules, Vol 8, Iss 4, p 147 (2018)
Our previous work identified a 12-amino acid peptide that targets the heart, termed cardiac targeting peptide (CTP). We now quantitatively assess the bio-distribution of CTP, show a clinical application with the imaging of the murine heart, and study
Externí odkaz:
https://doaj.org/article/7eba8903b1a048e5b0e34a2facd80038
Autor:
Huabo Wang, Jie Lu, Taylor Stevens, Alexander Roberts, Jordan Mandel, Raghunandan Avula, Yijen L. Wu, Jinglin Wang, Clinton Vant Land, Toren Finkel, Jerry Vockley, Merlin Airik, Rannar Airik, Radhika Muzumdar, Zhenwei Gong, Michel Torbenson, Edward Prochownik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::801d30091f62eef6a6239c35a8c686ae
https://doi.org/10.2139/ssrn.4358859
https://doi.org/10.2139/ssrn.4358859
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9789811956416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbe29d6da63688e209a49a5d0eccd952
https://doi.org/10.1007/978-981-19-5642-3_4
https://doi.org/10.1007/978-981-19-5642-3_4
Publikováno v:
Advances in experimental medicine and biology. 1396
Congenital heart disease (CHD) has a strong genetic etiology, making it a likely candidate for therapeutic intervention using genetic editing. Complex genetics involving an orchestrated series of genetic events and over 400 genes are responsible for
Autor:
Lina Ghaloul-Gonzalez, Sivakama S. Bharathi, Jerry Vockley, Anuradha Karunanidhi, Eric S. Goetzman, Manuel Schiff, Yudong Wang, Andrew Sinsheimer, Yijen L. Wu, Kailyn Bloom, Al-Walid Mohsen
Publikováno v:
Mol Genet Metab
Acyl CoA Dehydrogenase 9 (ACAD9) is a member of the family of flavoenzymes that catalyze the dehydrogenation of acyl-CoAs to 2,3 enoyl-CoAs in mitochondrial fatty acid oxidation (FAO). Inborn errors of metabolism of all family members, including ACAD
Autor:
Scott A. Hahn, Ying Tang, Mark T. Gladwin, Taijyu Satoh, Charles F. McTiernan, Kentaro Noda, Cynthia St. Hilaire, Bing Wang, Adam C. Straub, Samuel K. Wyman, Cristina Espinosa-Diez, Georgios Triantafyllou, Jeffrey J. Baust, Sruti Shiva, Matthew R Dent, Longfei Wang, Yijen L. Wu, Elena A. Goncharova, Dmitry A. Goncharov, Mike Reynolds, Yen Chun Lai, Andrea R. Levine, Elizabeth R. Rochon, Delphine Gomez, Stephen Y. Chan
Publikováno v:
Circulation
Circulation, vol 144, iss 8
Circulation, vol 144, iss 8
Background: Many patients with heart failure with preserved ejection fraction have metabolic syndrome and develop exercise-induced pulmonary hypertension (EIPH). Increases in pulmonary vascular resistance in patients with heart failure with preserved