Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Yihsuan S Tsai"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 5, p e1011095 (2023)
The clinical approvals of KRAS G12C inhibitors have been a revolutionary advance in precision oncology, but response rates are often modest. To improve patient selection, we developed an integrated model to predict KRAS dependency. By integrating mol
Externí odkaz:
https://doaj.org/article/ee05cc1fd97d4d6e93c0fe665bffe523
Autor:
Yihsuan S. Tsai, Mark G. Woodcock, Salma H. Azam, Leigh B. Thorne, Krishna L. Kanchi, Joel S. Parker, Benjamin G. Vincent, Chad V. Pecot
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 4 (2022)
BACKGROUND The KRAS proto-oncogene is among the most frequently mutated genes in cancer, yet for 40 years it remained an elusive therapeutic target. Recently, allosteric inhibitors that covalently bind to KRAS G12C mutations have been approved for us
Externí odkaz:
https://doaj.org/article/5223000f272e4197899612ea903e721e
Autor:
Ivan P. Gorlov, Kathleen Conway, Sharon N. Edmiston, Eloise A. Parrish, Honglin Hao, Christopher I. Amos, Spiridon Tsavachidis, Olga Y. Gorlova, Colin Begg, Eva Hernando, Chao Cheng, Ronglai Shen, Irene Orlow, Li Luo, Marc S. Ernstoff, Pei Fen Kuan, David W. Ollila, Yihsuan S. Tsai, Marianne Berwick, Nancy E. Thomas
Publikováno v:
Melanoma Research. 33:163-172
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da063e3970195d25dac5211ba81738fb
https://doi.org/10.1097/cmr.0000000000000881
https://doi.org/10.1097/cmr.0000000000000881
Autor:
W. Kimryn Rathmell, Cheryl L. Walker, Ruhee Dere, Joel S. Parker, Brian D. Strahl, Ian J. Davis, Abid Khan, Aguirre A. de Cubas, Yihsuan S. Tsai, Ryoma Ohi, Reid T. Powell, Pratim Chowdhury, Bo-Hwa Sohn, Charles B. Shuster, Menuka Karki, Catherine C. Fahey, Frank M. Mason, Durga Nand Tripathi, Esteban A. Terzo, In-Young Park, Yun-Chen Chiang
SETD2 loss promotes chromosomal abnormalities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cf572946bacc7499a8f3ac9594ff59
https://doi.org/10.1158/0008-5472.22419723.v1
https://doi.org/10.1158/0008-5472.22419723.v1
Autor:
W. Kimryn Rathmell, Cheryl L. Walker, Ruhee Dere, Joel S. Parker, Brian D. Strahl, Ian J. Davis, Abid Khan, Aguirre A. de Cubas, Yihsuan S. Tsai, Ryoma Ohi, Reid T. Powell, Pratim Chowdhury, Bo-Hwa Sohn, Charles B. Shuster, Menuka Karki, Catherine C. Fahey, Frank M. Mason, Durga Nand Tripathi, Esteban A. Terzo, In-Young Park, Yun-Chen Chiang
Loss of the short arm of chromosome 3 (3p) occurs early in >95% of clear cell renal cell carcinoma (ccRCC). Nearly ubiquitous 3p loss in ccRCC suggests haploinsufficiency for 3p tumor suppressors as early drivers of tumorigenesis. We previously repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b405439d92a4d44007c6c967ae1a3cf
https://doi.org/10.1158/0008-5472.c.6510453
https://doi.org/10.1158/0008-5472.c.6510453
Autor:
W. Kimryn Rathmell, Cheryl L. Walker, Ruhee Dere, Joel S. Parker, Brian D. Strahl, Ian J. Davis, Abid Khan, Aguirre A. de Cubas, Yihsuan S. Tsai, Ryoma Ohi, Reid T. Powell, Pratim Chowdhury, Bo-Hwa Sohn, Charles B. Shuster, Menuka Karki, Catherine C. Fahey, Frank M. Mason, Durga Nand Tripathi, Esteban A. Terzo, In-Young Park, Yun-Chen Chiang
fig legends for sup figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14971053ddde6dac6e1a07f8b4f7587d
https://doi.org/10.1158/0008-5472.22419699
https://doi.org/10.1158/0008-5472.22419699
Autor:
Evan S Dellon, Yihsuan S Tsai, Alisha R Coffey, Kelly Bodwin, Jared A Sninsky, Carson N Mosso, Tianshe M He, Kevin A O’Connor, Sara R Selitsky, Andrew B Nobel, Joel S Parker
Publikováno v:
Diseases of the Esophagus. 36
Summary Few predictors of response to topical corticosteroid (tCS) treatment have been identified in eosinophilic esophagitis (EoE). We aimed to determine whether baseline gene expression predicts histologic response to tCS treatment for EoE. We anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1285b36a0058b361d53b00111e2892
https://doi.org/10.1093/dote/doac071
https://doi.org/10.1093/dote/doac071
BackgroundThe clinical approvals of KRAS G12C inhibitors has been a revolutionary advance in precision oncology, but response rates are often modest. To improve patient selection, we developed an integrated model to predict KRAS dependency.Methods an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d7fb3dbdf83531871a60560857a1de
https://doi.org/10.1101/2022.07.07.499238
https://doi.org/10.1101/2022.07.07.499238
Publikováno v:
International Brazilian Journal of Urology, Vol 36, Iss 4, Pp 464-479 (2010)
PURPOSE: Interstitial cystitis/painful bladder syndrome (IC/PBS) is characterized by chronic pain, pressure and discomfort felt in the pelvis or bladder. An in-depth shotgun proteomics study was carried out to profile the urinary proteome of women wi
Externí odkaz:
https://doaj.org/article/ef868f58a07548e5ba2f3c4d944b3e77
Autor:
David W. Ollila, Paul B. Googe, Eloise Parrish, Nancy E. Thomas, Honglin Hao, Kathleen Conway, Glynis Scott, Pei Fen Kuan, Joel S. Parker, Jill S. Frank, Sharon N. Edmiston, Yihsuan S. Tsai
Publikováno v:
J Invest Dermatol
Cutaneous melanoma can be lethal even if detected at an early stage. Epigenetic profiling may facilitate the identification of aggressive primary melanomas with unfavorable outcomes. We performed clustering of whole-genome methylation data to identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85c339bb963a199914a95d91f829f84
https://europepmc.org/articles/PMC9135958/
https://europepmc.org/articles/PMC9135958/