Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Yih-Woei C. Fridell"'
Autor:
Ran-Der Hwang, Lyle Wiemerslage, Christopher J. LaBreck, Munzareen Khan, Kavitha Kannan, Xinglong Wang, Xiongwei Zhu, Daewoo Lee, Yih-Woei C. Fridell
Publikováno v:
Neurobiology of Disease, Vol 69, Iss , Pp 180-191 (2014)
Parkinson's disease (PD), caused by selective loss of dopaminergic (DA) neurons in the substantia nigra, is the most common movement disorder with no cure or effective treatment. Exposure to the mitochondrial complex I inhibitor rotenone recapitulate
Externí odkaz:
https://doaj.org/article/77bcd13f869f4ede956fadc27f5f6312
Autor:
Rafique Islam, Lichuan Yang, Megha Sah, Kavitha Kannan, Denise Anamani, Chibi Vijayan, Jenny Kwok, Marie E. Cantino, M. Flint Beal, Yih-Woei C. Fridell
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 1, Pp 137-146 (2012)
Parkinson's disease (PD), caused by selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta, is the most common movement disorder. While its etiology remains unknown, mitochondrial dysfunction is recognized as one of the maj
Externí odkaz:
https://doaj.org/article/f7365d0afb8f415084c3c7f47386fcd7
Autor:
Felipe Sierra, Yih-Woei C. Fridell
Metabolic interventions involving undernutrition but not malnutrition (e.g., caloric restriction, CR) are effective strategies for improving both health and longevity in species ranging from lower organisms to nonhuman primates. Initial human trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd77caee83e0c9c4e69098b76e3e189
https://doi.org/10.1016/bs.pmbts.2017.12.015
https://doi.org/10.1016/bs.pmbts.2017.12.015
Autor:
Jenny Kwok, Lichuan Yang, Megha Sah, Yih-Woei C. Fridell, Kavitha Kannan, Denise Anamani, Marie E. Cantino, M. Flint Beal, Chibi Vijayan, Rafique Islam
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 1, Pp 137-146 (2012)
Parkinson's disease (PD), caused by selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta, is the most common movement disorder. While its etiology remains unknown, mitochondrial dysfunction is recognized as one of the maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6c4a471bba9b0434908fa6a54468be
https://doi.org/10.1016/j.nbd.2011.12.055
https://doi.org/10.1016/j.nbd.2011.12.055
Publikováno v:
NeuroReport. 21:1116-1120
We sought to understand the mechanisms underlying glucose sensing in Drosophila melanogaster. We found that insulin-producing cells (IPCs) of adult Drosophila respond to glucose and glibenclamide with a burst-like pattern of activity. Under controlle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce2515c7125938a476f19a67cf4fa8fb
https://doi.org/10.1097/wnr.0b013e3283409200
https://doi.org/10.1097/wnr.0b013e3283409200
Autor:
Aaron T. Haselton, Yih-Woei C. Fridell
Publikováno v:
Aging (Albany NY)
Genetic ablation of Drosophila melanogaster insulin-like peptide (DILP) and adipokinetic hormone-producing cells accompanied by cell biological and metabolic measurements have revealed functional conservation in nutrient sensing and the underlying si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa0a1ffc66bc2ccbf040837af1a3de4
https://doi.org/10.18632/aging.100185
https://doi.org/10.18632/aging.100185
Publikováno v:
Cell Cycle. 9:3135-3143
In Drosophila melanogaster (D. melanogaster), neurosecretory insulin-like peptide-producing cells (IPCs), analogous to mammalian pancreatic beta cells are involved in glucose homeostasis. Extending those findings, we have developed in the adult fly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab24a09f9a74f1df9856fb2a7afa20a7
https://doi.org/10.4161/cc.9.15.12458
https://doi.org/10.4161/cc.9.15.12458
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2010, 19 (17), pp.3372-82. ⟨10.1093/hmg/ddq249⟩
Human Molecular Genetics, 2010, 19 (17), pp.3372-82. ⟨10.1093/hmg/ddq249⟩
Human Molecular Genetics, Oxford University Press (OUP), 2010, 19 (17), pp.3372-82. ⟨10.1093/hmg/ddq249⟩
Human Molecular Genetics, 2010, 19 (17), pp.3372-82. ⟨10.1093/hmg/ddq249⟩
International audience; Huntington's disease (HD) is a polyglutamine (polyQ) disease caused by an expanded CAG tract within the coding region of Huntingtin protein. Mutant Huntingtin (mHtt) is ubiquitously expressed, abundantly in neurons but also si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5588e9efc933fffbaa6719420b455c1f
https://doi.org/10.1093/hmg/ddq249
https://doi.org/10.1093/hmg/ddq249
Publikováno v:
Genetics. 172:1699-1710
A novel uncoupling protein, UCP5, has recently been characterized as a functional mitochondrial uncoupler in Drosophila. Here we demonstrate that UCP5 knockout (UCP5KO) flies are highly sensitive to starvation stress, a phenotype that can be reversed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe73b7a92ba8712046d17b46e1cc231
https://doi.org/10.1534/genetics.105.053389
https://doi.org/10.1534/genetics.105.053389
Publikováno v:
Journal of Bioenergetics and Biomembranes. 36:219-228
Sequence alignment of conserved signature motifs predicts the existence of the uncoupling protein 5 (UCP5)/brain mitochondrial carrier protein (BMCP1) homologue in Drosophila melanogaster (Hanak P. and Jezek P. (2001). FEBS Lett.495, pp. 137–141.).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a74357896dd2df4cdde3a3e6fd2a343
https://doi.org/10.1023/b:jobb.0000031973.20153.c6
https://doi.org/10.1023/b:jobb.0000031973.20153.c6