Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Yih Yang Chen"'
Autor:
Qin Dai, Stefan Wilhelm, Yih Yang Chen, Warren C. W. Chan, Ding Ding, Shrey Sindhwani, Abdullah Muhammad Syed, Presley MacMillan, Yuwei Zhang
Publikováno v:
ACS Nano. 12:8423-8435
Coating the nanoparticle surface with cancer cell recognizing ligands is expected to facilitate specific delivery of nanoparticles to diseased cells in vivo. While this targeting strategy is appealing, no nanoparticle-based active targeting formulati
Autor:
Abdullah Muhammad Syed, Warren C. W. Chan, Pamuditha N. Silva, Yih Yang Chen, Shrey Sindhwani, Jonathan V. Rocheleau
Publikováno v:
Proceedings of the National Academy of Sciences. 113:14915-14920
On-chip imaging of intact three-dimensional tissues within microfluidic devices is fundamentally hindered by intratissue optical scattering, which impedes their use as tissue models for high-throughput screening assays. Here, we engineered a microflu
Autor:
Julie Audet, Mayra Cruz Tleugabulova, Bo Tang, Anthony J. Tavares, Warren C. W. Chan, Wayne Ngo, Jonathan R. Krieger, Yih Yang Chen, Stefan Wilhelm, Thierry Mallevaey, James Lazarovits, Fayi Song, Qiaochu Lin, Yi-Nan Zhang
Publikováno v:
Nano letters. 19(1)
Nanoparticles are engineered from materials such as metals, polymers, and different carbon allotropes that do not exist within the body. Exposure to these exogenous compounds raises concerns surrounding toxicity, inflammation, and immune activation.
Autor:
Jonathan V. Rocheleau, Presley MacMillan, Yih Yang Chen, Abdullah Muhammad Syed, Warren C. W. Chan
Publikováno v:
Advanced Materials. 32:1906274
Nanoparticles are commonly administered through systemic injection, which exposes them to the dynamic environment of the bloodstream. Injected nanoparticles travel within the blood and experience a wide range of flow velocities that induce varying sh
Publikováno v:
Advanced Materials Technologies. 5:2000103
Publikováno v:
Chemical Communications. 51:2756-2767
Nanoparticles are suitable platforms for cancer targeting and diagnostic applications. Typically, less than 10% of all systemically administered nanoparticles accumulate in the tumour. Here we explore the interactions of blood components with nanopar
Autor:
Mark A. Eckert, Weian Zhao, Yih Yang Chen, Leonard S. Sender, David A. Fruman, Zhiqing Zhang, Dong-Ku Kang, M. Monsur Ali
Publikováno v:
Biomaterials. 34:9728-9735
Poor efficacy and off-target systemic toxicity are major problems associated with current chemotherapeutic approaches to treat cancer. We developed a new form of polyvalent therapeutics that is composed of multiple aptamer units synthesized by rollin
Autor:
Jonathan V. Rocheleau, Romario Regeenes, Pamuditha N. Silva, Uilki Tufa, Dawn M. Kilkenny, Zaid Atto, Yih Yang Chen, Allen Volchuk, Warren C. W. Chan
Publikováno v:
Lab on a chip. 16(15)
Tissues are challenging to genetically manipulate due to limited penetration of viral particles resulting in low transduction efficiency. We are particularly interested in expressing genetically-encoded sensors in ex vivo pancreatic islets to measure
Autor:
Dylan Glancy, Warren C. W. Chan, Michael Dobosz, Shrey Sindhwani, Yih Yang Chen, Stefan Wilhelm, Abdullah Muhammad Syed
Publikováno v:
ACS nano. 10(5)
The role of tissue architecture in mediating nanoparticle transport, targeting, and biological effects is unknown due to the lack of tools for imaging nanomaterials in whole organs. Here, we developed a rapid optical mapping technique to image nanoma
Autor:
Katherine E. Brechun, Stacy-Anne Morgan, Yih-Yang Chen, Helen Y. Fan, G. Andrew Woolley, Anna S. I. Jaikaran
Publikováno v:
Biochemistry. 50:1226-1237
Photocontrolled transcription factors could be powerful tools for probing the roles of transcriptional processes in a variety of settings. Previously, we designed a photocontrolled DNA-binding protein based on a fusion between the bZIP region of GCN4