Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Yih Hsin Chang"'
Autor:
Yu-Li Lo, Ching-Yao Li, Tsui-Fen Chou, Ching-Ping Yang, Li-Ling Wu, Chun-Jung Chen, Yih-Hsin Chang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116660- (2024)
Pancreatic ductal adenocarcinoma (PDAC) has an extremely devastating nature with poor prognosis and increasing incidence, making it a formidable challenge in the global fight against cancer-related mortality. In this innovative preclinical investigat
Externí odkaz:
https://doaj.org/article/d2e23416c3de49658faa8ae2328aedf3
Autor:
Yih-Hsin Chang, Shu-Wen Chang, Wei-Ting Hsu, Ching-Ping Yang, Yu-Li Lo, Chun-Jung Chen, Hui-Fang Tsai, Ming-Yuh Shiau
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2603 (2022)
Our previous studies demonstrated that collapsin response mediator protein 2 (CRMP2) is associated with obesity and, in addition, that hyperglycemia-suppressed CRMP2 augments malignant traits of colorectal cancer and is associated with advanced tumor
Externí odkaz:
https://doaj.org/article/488b46fd7b98469098bd5ed24b0fde40
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1759 (2022)
Dysregulational EGFR, KRAS, and mTOR pathways cause metabolic reprogramming, leading to progression of gastric cancer. Afatinib (Afa) is a broad-spectrum tyrosine kinase inhibitor that reduces cancer growth by blocking the EGFR family. MicroRNA 125 (
Externí odkaz:
https://doaj.org/article/91e17c3dfa764680b3a1a29db98a2345
Autor:
Yih-Hsin Chang, Hui-Ju Yang, Huan-Wen Chen, Chiao-Wan Hsiao, Yi-Chen Hsieh, Yu-Wei Chan, Shu-Wen Chang, Wei-Lun Hwang, Wei-Shone Chen, Hou-Hsuan Cheng, Teh-Ying Chou, Fu-Pang Chang, Hsiang-Ling Ho, Fang-Yeh Chu, Yu-Li Lo, Chun-Jung Chen, Hui-Fang Tsai, Ming-Yuh Shiau
Publikováno v:
Cells, Vol 11, Iss 4, p 727 (2022)
Background: Common demographic risk factors are identified in colorectal cancer (CRC) and type 2 diabetes mellitus (DM), nevertheless, the molecular link and mechanism for CRC-DM comorbidity remain elusive. Dysregulated glycogen synthase kinase-3 bet
Externí odkaz:
https://doaj.org/article/62d7ba1ee1a041a7b60b37d6922eca8e
Publikováno v:
AIMS Allergy and Immunology, Vol 1, Iss 4, Pp 181-193 (2017)
Elevated resistin levels and the polymorphisms located at gene encoding resistin (RETN) are associated with diabetic pathogenesis. However, the correlation between RETN genotypes and T2DM is controversial due to discrepancies among reports. This stud
Externí odkaz:
https://doaj.org/article/a8e01ea46acc42bc8a7bcc4323a05471
Autor:
Yih-Hsin Chang, Jen-Ning Tsai, Tzu-Lin Chen, Kuo-Ting Ho, Hsin-Yi Cheng, Chiao-Wan Hsiao, Ming-Yuh Shiau
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
Anti-inflammatory cytokine interleukin-4 (IL-4) promotes glucose tolerance and insulin sensitivity while reduces lipid deposits. However, the effects of IL-4 on energy metabolism in muscle, the largest insulin-targeting organ, remain obscure. The stu
Externí odkaz:
https://doaj.org/article/9c7ed4262c6b45b899aab38b54fb53e9
Autor:
Yu-Li Lo, Chen-Shen Wang, Yen-Chun Chen, Tse-Yuan Wang, Yih-Hsin Chang, Chun-Jung Chen, Ching-Ping Yang
Publikováno v:
Pharmaceutics, Vol 12, Iss 8, p 756 (2020)
Mitochondrial dysfunction may cause cancer and metabolic syndrome. Ellagic acid (abbreviated as E), a phytochemical, possesses anticancer activity. MicroRNA 125 (miR-125) may regulate metabolism. However, E has low aqueous solubility, and miR-125 is
Externí odkaz:
https://doaj.org/article/9c2cd2f1cf5449c6a882d0b0072473ae
Autor:
Yuh-Jen Cheng, Chao-Chi Liu, Fang-Yeh Chu, Ching-Ping Yang, Chiao-Wan Hsiao, Cheng-Wei Chuang, Ming-Yuh Shiau, Hsueh-Te Lee, Jen-Ning Tsai, Yih-Hsin Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5493 (2020)
The expansion of adipose tissue mass is the primary characteristic of the process of becoming obesity, which causes chronic adipose inflammation and is closely associated with type 2 diabetes mellitus (T2DM). Adipocyte hypertrophy restricts oxygen av
Externí odkaz:
https://doaj.org/article/88e59da711684032a1a1200a954fc5c5
Autor:
Shih-Yi Lin, Ching-Ping Yang, Ya-Yu Wang, Chiao-Wan Hsiao, Wen-Ying Chen, Su-Lan Liao, Yu-Li Lo, Yih-Hsin Chang, Chen-Jee Hong, Chun-Jung Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4451 (2020)
Obesity is a metabolic disorder that results from complex interactions between genetic predisposition and dietary factors. Interleukin-4 (IL-4), besides its role in immunity, has metabolic effects on insulin efficacy. We studied the effects of IL-4 o
Externí odkaz:
https://doaj.org/article/8570de7475de4535bc6309f3be531f44
Autor:
Yih-Hsin Chang, Jen-Ning Tsai, Shu-Wen Chang, Wei-Ting Hsu, Ching-Ping Yang, Chiao-Wan Hsiao, Ming-Yuh Shiau
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2172 (2020)
As emerging evidence suggesting neurodegenerative diseases and metabolic diseases have common pathogenesis, we hypothesized that the neurite outgrowth-controlling collapsin response mediator protein 2 (CRMP2) was involved in energy homeostasis. There
Externí odkaz:
https://doaj.org/article/12904cd16a83466db2e70358c3b0d46d