Development of Dual ARV-825 and Nintedanib-Loaded PEGylated Nano-Liposomes for Synergistic Efficacy in Vemurafnib-Resistant Melanoma

Autor: Yige Fu, Aishwarya Saraswat, Zenghui Wei, Manas Yogendra Agrawal, Vikas V. Dukhande, Sandra E. Reznik, Ketan Patel

Publikováno v: Pharmaceutics, Vol 13, Iss 7, p 1005 (2021)

A novel treatment strategy by co-targeting c-Myc and tumor stroma was explored in vemurafenib-resistant melanoma. BRD4 proteolysis targeting chimera (ARV-825) and nintedanib co-loaded PEGylated nanoliposomes (ARNIPL) were developed to incorporate a s

Externí odkaz: https://doaj.org/article/c3edc51cc9e54d0a8d8965a4cd2cc24c

Spectroscopy-Based Local Modeling Method for High-Throughput Quantification of Nucleic Acid Loading in Lipid Nanoparticles

Autor: Yuchen Fan, Zhenqi Shi, Shengli Ma, Sayyeda Zeenat Anwer Razvi, Yige Fu, Tao Chen, Jason Gruenhagen, Kelly Zhang

Publikováno v: Analytical Chemistry. 94:9081-9090

Lipid nanoparticles (LNPs) are the most widely investigated delivery systems for nucleic acid-based therapeutics and vaccines. Loading efficiency of nucleic acids may vary with formulation conditions, and it is considered one of the critical quality

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40860a7e009a79c454bb374df7431f41
https://doi.org/10.1021/acs.analchem.2c01346

Analytical techniques for characterizing diastereomers of phosphorothioated oligonucleotides

Autor: Tao Chen, Shijia Tang, Yige Fu, José G. Napolitano, Kelly Zhang

Publikováno v: Journal of chromatography. A. 1678

Oligonucleotides have emerged as powerful therapeutics for treating diverse diseases. To fully unlock the therapeutic potential of oligonucleotides, there is still a great need to further improve their drug-like properties. Numerous chemical modifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8f5b7d3b1ba1d1cce3198a63071f7b
https://pubmed.ncbi.nlm.nih.gov/35908512

Contributors

Autor: Aashruti Agrawal, Farhan Jalees Ahmad, Faria Ali, null Alka, Mohd. Aqil, M. Arockia Babu, Venkatesh Teja Banala, Sarwar Beg, Aditi Bhat, Valamla Bhavana, Padakanti Sandeep Chary, Vikas Chaudhary, Akash Chaurasiya, Manish K. Chourasia, Harshita Dalvi, Yige Fu, Amruta Gorajiya, Mimansa Goyal, Monica Gulati, Vivek Gupta, Harsha Jain, Dhara Jain, Nitin Jain, Isha Joshi, Kiran Jyoti, Manpreet Kaur, Ayesha Khan, Dharmendra Kumar Khatri, Parveen Kumar, Preeti Kush, Praveen Lakhera, Jitender Madan, Srushti Mahajan, Indrani Maji, Priyanka Maurya, Neelesh Kumar Mehra, Charu Misra, Keerti Mishra, Nidhi Mishra, Dhrubojyoti Mukherjee, Jatinder Kaur Mukker, Jayabalan Nirmal, Raquibun Nisha, Ravi Raj Pal, Vineela Parvathaneni, Ketan Patel, Manali Patki, Rakesh Kumar Paul, Purva Pingle, Ravi Shankar Prasad Singh, Abdul Qadir, Naveen Rajana, Manoj Rawat, Kaisar Raza, Vaskuri G.S. Sainaga Jyothi, Shubhini A. Saraf, Aishwarya Saraswat, Satish Sardana, Deep Shikha Sharma, null Shubhra, Snehal K. Shukla, Neelu Singh, Pankaj Kumar Singh, Priya Singh, Sachin Kumar Singh, Samipta Singh, Shashi Bala Singh, Yuvraj Singh, Rupinder Kaur Sodhi, Veerabomma Haritha Sree, Anitha Sriram, Saurabh Srivastava, Amrendra K. Tiwari, Richa Vartak, Sheetu Wadhwa, Xuechun Wang, Pavan K. Yadav, Sobiya Zafar

Publikováno v: Multifunctional Nanocarriers ISBN: 9780323850414

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fa321547f8a8e5c189e4e7fc51def72
https://doi.org/10.1016/b978-0-323-85041-4.01002-7

Stromal disruption facilitating invasion of a 'nano-arsenal' into the solid tumor

Autor: Yige Fu, Jasmin Monpara, Aishwarya Saraswat, Ketankumar Patel

Publikováno v: Drug discovery today. 27(4)

Owing to the indispensable role of nanotechnology in cancer therapy, it is imperative to comprehend every aspect limiting its therapeutic potential. Several preclinical reports have demonstrated the enhanced permeability and retention (EPR)-mediated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec050c7207b3e5f1ed762122039fc4ce
https://pubmed.ncbi.nlm.nih.gov/34823002