Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Yifeng, Chai"'
Publikováno v:
Responsive Materials, Vol 2, Iss 2, Pp n/a-n/a (2024)
Abstract Considering the continuous advances in the synthesis and clinical applications of monoclonal antibodies (mAbs), precision therapies that employ mAbs are essential. In recent years, extensive efforts have been invested in developing novel str
Externí odkaz:
https://doaj.org/article/60bae97ee9bc46d692e021214f9cc01a
Autor:
Minyu Qi, Diya Lv, Ying Zhang, Dongyao Wang, Xiaofei Chen, Zhenyu Zhu, Zhanying Hong, Yifeng Chai, Hai Zhang, Yan Cao
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 12, Iss 6, Pp 929-936 (2022)
Therapeutic drug monitoring (TDM) has played an important role in clinical medicine for precise dosing. Currently, chromatographic technology and immunoassay detection are widely used in TDM and have met most of the needs of clinical drug therapy. Ho
Externí odkaz:
https://doaj.org/article/544cb3e360ae45a99ab55a0a70b14363
Autor:
Xinyi Chai, Yanqiu Gu, Lei Lv, Chun Chen, Fei Feng, Yan Cao, Yue Liu, Zhenyu Zhu, Zhanying Hong, Yifeng Chai, Xiaofei Chen
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 12, Iss 5, Pp 725-732 (2022)
Astragali Radix (AR) is a clinically used herbal medicine with multiple immunomodulatory activities that can strengthen the activity and cytotoxicity of natural killer (NK) cells. However, owing to the complexity of its composition, the specific acti
Externí odkaz:
https://doaj.org/article/7fd586da386841f8b747c07e0eb048b4
Autor:
Yanqiu Gu, Rong Wang, Panpan Chen, Shengnan Li, Xinyi Chai, Chun Chen, Yue Liu, Yan Cao, Diya Lv, Zhanying Hong, Zhenyu Zhu, Yifeng Chai, Yongfang Yuan, Xiaofei Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 9, Pp 3682-3693 (2022)
Cell membrane affinity chromatography has been widely applied in membrane protein (MP)-targeted drug screening and interaction analysis. However, in current methods, the MP sources are derived from cell lines or recombinant protein expression, which
Externí odkaz:
https://doaj.org/article/c20e0e06ba1f4de8bf684c577c07251e
Autor:
Yuhong Cao, Jiahao Fang, Yiwei Shi, Hui Wang, Xiaofei Chen, Yue Liu, Zhenyu Zhu, Yan Cao, Zhanying Hong, Yifeng Chai
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 7, Pp 3113-3123 (2022)
P-glycoprotein (P-gp) highly expressed in cancer cells can lead to multidrug resistance (MDR) and the combination of anti-cancer drugs with P-gp inhibitor has been a promising strategy to reverse MDR in cancer treatment. In this study, we established
Externí odkaz:
https://doaj.org/article/e71ec7bfa1954341a854526397d30218
Autor:
Dan Jia, Chunliang Liu, Zhenyu Zhu, Yan Cao, Wen Wen, Zhanying Hong, Yue Liu, Erdong Liu, Long Chen, Chun Chen, Yanqiu Gu, Binghua Jiao, Yifeng Chai, Hong‐yang Wang, Jing Fu, Xiaofei Chen
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 11, Pp n/a-n/a (2022)
Abstract Background Transketolase (TKT), a key rate‐limiting enzyme in the non‐oxidative branch of the pentose phosphate pathway (PPP), provides more than 85% of the ribose required for de novo nucleotide biosynthesis and promotes the development
Externí odkaz:
https://doaj.org/article/9d926398c100402db3fef7a7bef6aea4
Autor:
Xiaofei Chen, Yunlong Wu, Chun Chen, Yanqiu Gu, Chunyan Zhu, Suping Wang, Jiayun Chen, Lei Zhang, Lei Lv, Guoqing Zhang, Yongfang Yuan, Yifeng Chai, Mingshe Zhu, Caisheng Wu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 222-236 (2021)
Lianhuaqingwen (LHQW) capsule, a herb medicine product, has been clinically proved to be effective in coronavirus disease 2019 (COVID-19) pneumonia treatment. However, human exposure to LHQW components and their pharmacological effects remain largely
Externí odkaz:
https://doaj.org/article/30ba5807875449f4a090c9169c96025b
Autor:
Yanqiu Gu, Xiao Chen, Yao Wang, Yue Liu, Leyi Zheng, Xiaoqun Li, Rong Wang, Shaozhan Wang, Shengnan Li, Yifeng Chai, Jiacan Su, Yongfang Yuan, Xiaofei Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 1856-1865 (2020)
Osteoporosis is a bone metabolic disease caused by the imbalance between osteoblasts and osteoclasts due to excess osteoclastogenesis, manifesting in the decrease of bone density and bone strength. Scutellariae Radix shows good anti-osteoporosis acti
Externí odkaz:
https://doaj.org/article/3d1db796ee4a48759b77ee4048fbe120
Autor:
Jianying Dai, Yuzhen He, Jiahao Fang, Hui Wang, Liang Chao, Liang Zhao, Zhanying Hong, Yifeng Chai
Publikováno v:
Molecules, Vol 27, Iss 23, p 8556 (2022)
The efficacy and pharmacokinetics of the biologically active components in Anemarrhenae rhizoma (AR) would be affected by the interaction of P-glycoprotein(P-gp) and effective components in AR. However, little is known about the interaction between t
Externí odkaz:
https://doaj.org/article/e70d7225cca5401a9b0adb0086256027
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 9, Iss 2, Pp 71-76 (2019)
Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported. The process of necroptosis is regulated and plays a critical role in the
Externí odkaz:
https://doaj.org/article/969720cb88bb4499b9026c060020351c