Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Yien Che Tsai"'
Autor:
Yien Che Tsai, Loren Kozar, Zo P. Mawi, Konstantin Ichtchenko, Charles B. Shoemaker, Patrick M. McNutt, Allan M. Weissman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7472 (2024)
Botulinum neurotoxins are some of the most potent natural toxins known; they cause flaccid paralysis by inhibiting synaptic vesicle release. Some serotypes, notably serotype A and B, can cause persistent paralysis lasting for several months. Because
Externí odkaz:
https://doaj.org/article/1c5f353faf6a48329e6e910d8fd915d8
Autor:
Sandeep K. Singhal, Jung S. Byun, Tingfen Yan, Ryan Yancey, Ambar Caban, Sara Gil Hernandez, Sediqua Bufford, Stephen M. Hewitt, Joy Winfield, Jaya Pradhan, Vesco Mustkov, Jasmine A. McDonald, Eliseo J. Pérez-Stable, Anna María Nápoles, Nasreen Vohra, Adriana De Siervi, Clayton Yates, Melissa B. Davis, Mei Yang, Yien Che Tsai, Allan M. Weissman, Kevin Gardner
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Women of African ancestry suffer higher rates of breast cancer mortality compared with all other groups in the United States. Though the precise reasons for these disparities remain unclear, many recent studies have implicated a role for differences
Externí odkaz:
https://doaj.org/article/d8136019c67d48819c70238b6e5115e2
Autor:
Kerrie L. Marie, Antonella Sassano, Howard H. Yang, Aleksandra M. Michalowski, Helen T. Michael, Theresa Guo, Yien Che Tsai, Allan M. Weissman, Maxwell P. Lee, Lisa M. Jenkins, M. Raza Zaidi, Eva Pérez-Guijarro, Chi-Ping Day, Kris Ylaya, Stephen M. Hewitt, Nimit L. Patel, Heinz Arnheiter, Sean Davis, Paul S. Meltzer, Glenn Merlino, Pravin J. Mishra
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Metastatic cells can mimic many of the phenotypic behaviors of embryonic cells. Here, the authors generate a melanoblast-specific transcriptome using a genetically engineered mouse model and identify KDELR3 as a pro-metastasis gene in melanoma.
Externí odkaz:
https://doaj.org/article/35727847607f4f45b98d5dc601c357f5
Autor:
Christopher E Smith, Yien Che Tsai, Yu-He Liang, Domarin Khago, Jennifer Mariano, Jess Li, Sergey G Tarasov, Emma Gergel, Borong Tsai, Matthew Villaneuva, Michelle E Clapp, Valentin Magidson, Raj Chari, R Andrew Byrd, Xinhua Ji, Allan M Weissman
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001474 (2021)
Endoplasmic reticulum-associated degradation (ERAD) is a protein quality control pathway of fundamental importance to cellular homeostasis. Although multiple ERAD pathways exist for targeting topologically distinct substrates, all pathways require su
Externí odkaz:
https://doaj.org/article/1d1767c146ff4ca2be2d36cff2726f11
Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus.
Autor:
Joseph W Briggs, Ling Ren, Kristi R Chakrabarti, Yien Che Tsai, Allan M Weissman, Ryan J Hansen, Daniel L Gustafson, Yousuf A Khan, Jonathan D Dinman, Chand Khanna
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185089 (2017)
Activation of the unfolded protein response (UPR) in eukaryotic cells represents an evolutionarily conserved response to physiological stress. Here, we report that the mTOR inhibitors rapamycin (sirolimus) and structurally related temsirolimus are ca
Externí odkaz:
https://doaj.org/article/21191385288e488bb0ace408ca335cc3
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e92290 (2014)
Prion protein PrP is a central player in several devastating neurodegenerative disorders, including mad cow disease and Creutzfeltd-Jacob disease. Conformational alteration of PrP into an aggregation-prone infectious form PrPSc can trigger pathogenic
Externí odkaz:
https://doaj.org/article/b9528e2ebfb5419eaa60cf8cb8259d08
Autor:
Yien Che Tsai, Allan M Weissman
Publikováno v:
PLoS Biology, Vol 9, Iss 3, p e1001038 (2011)
Proteins are co-translationally inserted into the endoplasmic reticulum (ER) where they undergo maturation. Homeostasis in the ER requires a highly sensitive and selective means of quality control. This occurs through ER-associated degradation (ERAD)
Externí odkaz:
https://doaj.org/article/6d0ea9a4d8194b92a6fdd21ef6c0001b
Autor:
Damali N Martin, Brenda J Boersma, Ming Yi, Mark Reimers, Tiffany M Howe, Harry G Yfantis, Yien Che Tsai, Erica H Williams, Dong H Lee, Robert M Stephens, Allan M Weissman, Stefan Ambs
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4531 (2009)
African-American breast cancer patients experience higher mortality rates than European-American patients despite having a lower incidence of the disease. We tested the hypothesis that intrinsic differences in the tumor biology may contribute to this
Externí odkaz:
https://doaj.org/article/278b7c636a6a4ab28884f281f7f9d357
Autor:
Allan M. Weissman, Karen H. Vousden, John A. Beutler, John H. Kenten, Chou-Chi H. Li, Pankaj Oberoi, Ilia V. Davydov, Jane P. Jensen, Shervon A. Pierre, Robert L. Ludwig, Kevin L. Lorick, Yien Che Tsai, Ren-Ming Dai, Jirouta Kitagaki, Yili Yang
The conjugation of proteins with ubiquitin plays numerous regulatory roles through both proteasomal-dependent and nonproteasomal-dependent functions. Alterations in ubiquitylation are observed in a wide range of pathologic conditions, including numer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc1227002443a3063ad1af58535618d
https://doi.org/10.1158/0008-5472.c.6496439.v1
https://doi.org/10.1158/0008-5472.c.6496439.v1
Autor:
Allan M. Weissman, Karen H. Vousden, John A. Beutler, John H. Kenten, Chou-Chi H. Li, Pankaj Oberoi, Ilia V. Davydov, Jane P. Jensen, Shervon A. Pierre, Robert L. Ludwig, Kevin L. Lorick, Yien Che Tsai, Ren-Ming Dai, Jirouta Kitagaki, Yili Yang
Supplementary Figures 1-8 from Inhibitors of Ubiquitin-Activating Enzyme (E1), a New Class of Potential Cancer Therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce062a4d872eee53295c21e6dfd6cce
https://doi.org/10.1158/0008-5472.22370567
https://doi.org/10.1158/0008-5472.22370567