Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Yichin Liu"'
Autor:
Aimee Fourie-O’Donohue, Phillip Y. Chu, Josefa dela Cruz Chuh, Robert Tchelepi, Siao Ping Tsai, John C. Tran, William S. Sawyer, Dian Su, Carl Ng, Keyang Xu, Shang-Fan Yu, Thomas H. Pillow, Jack Sadowsky, Peter S. Dragovich, Yichin Liu, Katherine R. Kozak
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
For antibody-drug conjugates to be efficacious and safe, they must be stable in circulation to carry the payload to the site of the targeted cell. Several components of a drug-conjugated antibody are known to influence stability: 1) the site of drug
Externí odkaz:
https://doaj.org/article/e46e20ec184a4063ba55b87d5b9f2d28
Autor:
John C. Tran, Thomas Hunsaker, Christina Bell, Taylur P. Ma, Emily Chan, Pablo Saenz-Lopez Larrocha, Kelsey Homyk, Liling Liu, Hank La, Jialin Mao, Cecile C. de la Cruz, Kebing Yu, Maureen Beresini, William F. Forrest, Yang Xiao, Anne Jang, Natalia Samus, Nicholas Dupuis Stesco, Marija Mentinova, Stephane Parent, Gwenael Pottiez, Michael Schirm, Hans E. Purkey, Yichin Liu, Mark Merchant
Publikováno v:
Analytical Chemistry. 95:4834-4839
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ea38580cf5f1df5004a2b5d1c9e5ae9
https://doi.org/10.1021/acs.analchem.2c04417
https://doi.org/10.1021/acs.analchem.2c04417
Autor:
Cong, Wu, Ryan, Cook, Ping, Wu, Neha, Srikumar, Elin, Chee, William S, Sawyer, Hua, Wang, Meredith, Hazen, Isidro, Hotzel, Elsa-Noah, N'Diaye, Ning, Ding, Yichin, Liu, John C, Tran, Zhengmao, Ye
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:6601-6610
Proteases are critical proteins involved in cleaving substrates that may impact biological pathways, cellular processes, or disease progression. In the biopharmaceutical industry, modulating the levels of protease activity is an important strategy fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6cf2455a7b136a2e0665fb30ea7f35f
https://doi.org/10.1007/s00216-022-04220-2
https://doi.org/10.1007/s00216-022-04220-2
Autor:
Andrew G. Polson, Mark X. Sliwkowski, Robert W. Akita, Byoung-Chul Lee, Benjamin Haley, Qui Phung, Tommy K. Cheung, Jack Sadowsky, Thomas H. Pillow, Yichin Liu, Katherine R. Kozak, Donglu Zhang, Yong Ma, Josefa dela Cruz Chuh, Niña G. Caculitan
Supplementary Figure 5: Control spectrum obtained via quantitative LC-MS for the anti-HER2-VC(S)-MMAE ADC after 3 hours with in buffer with no proteolytic solution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbcee4c6000a7344ad67ea80f2ffb1d8
https://doi.org/10.1158/0008-5472.22416947.v1
https://doi.org/10.1158/0008-5472.22416947.v1
Autor:
Andrew G. Polson, Mark X. Sliwkowski, Robert W. Akita, Byoung-Chul Lee, Benjamin Haley, Qui Phung, Tommy K. Cheung, Jack Sadowsky, Thomas H. Pillow, Yichin Liu, Katherine R. Kozak, Donglu Zhang, Yong Ma, Josefa dela Cruz Chuh, Niña G. Caculitan
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52077034dd3017dea4fca6c949c037c
https://doi.org/10.1158/0008-5472.22416935.v1
https://doi.org/10.1158/0008-5472.22416935.v1
Autor:
Andrew G. Polson, Mark X. Sliwkowski, Robert W. Akita, Byoung-Chul Lee, Benjamin Haley, Qui Phung, Tommy K. Cheung, Jack Sadowsky, Thomas H. Pillow, Yichin Liu, Katherine R. Kozak, Donglu Zhang, Yong Ma, Josefa dela Cruz Chuh, Niña G. Caculitan
Antibody–drug conjugates (ADC) are designed to selectively bind to tumor antigens via the antibody and release their cytotoxic payload upon internalization. Controllable payload release through judicious design of the linker has been an early techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35b8ea5d91de0b8b1b320419f56d8e61
https://doi.org/10.1158/0008-5472.c.6509693.v1
https://doi.org/10.1158/0008-5472.c.6509693.v1
Autor:
Neha Srikumar, Joseph Carver, Christoph Spiess, John C. Tran, Ambrose Williams, Yichin Liu, Amy Shen, Phillip Y. Chu, Cong Wu, Ankai Xu, William S. Sawyer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance While electrospray ionization–mass spectrometry (ESI-MS) provides higher resolution for larger proteins, the conventional liquid chromatography (LC)-MS method suffers from low throughput. Our described RapidFire-MS workflow demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842c2cdb134e11180cf936e2e39f7186
https://doi.org/10.1073/pnas.1917383117
https://doi.org/10.1073/pnas.1917383117
Autor:
Wen Liu, Amy Gustafson, Firoz Jaipuri, Erica VanderPorten, Leanne Goon, Yamin Zhang, Guosheng Wu, Zuhui Zhang, Antonio G. DiPasquale, Xiaokai Li, Angela J. Oh, Lewis J. Gazzard, Seth F. Harris, Jesse Waldo, Roheeth Kumar Pavana, Yichin Liu, Venkata Velvadapu, Cheng Shao, Yuen Po-Wai, Mario R. Mautino, Zhonghua Pei, Hank La, Hima Potturi, Georgette Castanedo, Benjamin D. Sellers, Kevin DeMent, Sanjeev Kumar, Richard Pastor, Rohan Mendonca, Brendan T. Parr
Publikováno v:
ACS Med Chem Lett
[Image: see text] A class of imidazoisoindole (III) heme-binding indoleamine-2,3-dioxygenase (IDO1) inhibitors were optimized via structure-based drug design into a series of tryptophan-2,3-dioxygenase (TDO)-selective inhibitors. Kynurenine pathway m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701dd22f186bad66eefde1770830d8d6
https://doi.org/10.1021/acsmedchemlett.0c00004
https://doi.org/10.1021/acsmedchemlett.0c00004
Autor:
Thomas H. Pillow, Yuzhong Deng, Katherine R. Kozak, Peter S. Dragovich, Liling Liu, Robert T. Cass, Yichin Liu, S. Cyrus Khojasteh, Aimee Fourie-O'Donohue, Donglu Zhang, Jack Sadowsky, Cornelis E. C. A. Hop
Publikováno v:
Drug Metabolism and Disposition. 47:1156-1163
In cells, catalytic disulfide cleavage is an essential mechanism in protein folding and synthesis. However, detailed enzymatic catalytic mechanism relating cleavage of disulfide bonds in xenobiotics is not well understood. This study reports an enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e8affd3c247730a18fefcdc3bf9965
https://doi.org/10.1124/dmd.118.086132
https://doi.org/10.1124/dmd.118.086132
Autor:
Robert Tchelepi, John C. Tran, William F. Forrest, Greg A. Lazar, Neha Srikumar, Yichin Liu, Wenjing Li, Chen Gu, Diego Ellerman
Publikováno v:
Analytical chemistry. 92(10)
There are many pharmacokinetic challenges associated with administering protein therapeutics, including biotransformation via clipping, deamidation, isomerization, oxidation, etc. In the case of engineered multivalent tethered antibody formats, prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec90ccf3093af52c614862aeaa95536
https://pubmed.ncbi.nlm.nih.gov/32309925
https://pubmed.ncbi.nlm.nih.gov/32309925