Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Yichen Dai"'
Autor:
Juan Du, Weiqiang Liu, Meng Li, Zihao Li, Xuanjing Li, Yichen Dai, Gaoming Liu, Xiao Wang, Pingfen Zhu, Vadim N Gladyshev, Xuming Zhou
Publikováno v:
PLoS Biology, Vol 22, Iss 8, p e3002778 (2024)
The naked mole rat (NMR), Heterocephalus glaber, is known as the longest-lived rodent and is extraordinarily resistant to hypoxia and cancer. Here, both NMR embryonic fibroblasts (NEFs) and their mouse counterparts (MEFs) were subjected to anoxic con
Externí odkaz:
https://doaj.org/article/4244d1b9a66e4a2b9dcb975b7e59a472
Engineering RsDddA as mitochondrial base editor with wide target compatibility and enhanced activity
Autor:
Kai Cheng, Cao Li, Jiachuan Jin, Xuezhen Qian, Jiayin Guo, Limini Shen, YiChen Dai, Xue Zhang, Zhanwei Li, Yichun Guan, Fei Zhou, Jin Tang, Jun Zhang, Bin Shen, Xin Lou
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102028- (2023)
Double-stranded DNA-specific cytidine deaminase (DddA) base editors hold great promise for applications in bio-medical research, medicine, and biotechnology. Strict sequence preference on spacing region presents a challenge for DddA editors to reach
Externí odkaz:
https://doaj.org/article/dcee89cade424d6faec9da6c74ede72b
Autor:
Jiayin Guo, Xiaoxu Chen, Zhiwei Liu, Haifeng Sun, Yu Zhou, Yichen Dai, Yu'e Ma, Lei He, Xuezhen Qian, Jianying Wang, Jie Zhang, Yichen Zhu, Jun Zhang, Bin Shen, Fei Zhou
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 73-80 (2022)
Critical mutations of mitochondrial DNA (mtDNA) generally lead to maternally inheritable diseases that affect multiple organs and systems; however, it was difficult to alter mtDNA in mammalian cells to intervene in or cure mitochondrial disorders. Re
Externí odkaz:
https://doaj.org/article/d0efd2d09726457fb6ad0eba937a0219
Autor:
Xiaoxu Chen, Dong Liang, Jiayin Guo, Junqiang Zhang, Haifeng Sun, Xiaolan Zhang, Jiachuan Jin, Yichen Dai, Qinmin Bao, Xuezhen Qian, Lei Tan, Ping Hu, Xiufeng Ling, Bin Shen, Zhengfeng Xu
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/f46a566c80354612bc230ef0dac7b4c4
Autor:
Jiayin Guo, Xue Zhang, Xiaoxu Chen, Haifeng Sun, Yichen Dai, Jianying Wang, Xuezhen Qian, Lei Tan, Xin Lou, Bin Shen
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-5 (2021)
Externí odkaz:
https://doaj.org/article/84d8f74318724cf3894d45abf689ce06
Divergent genes in gerbils: prevalence, relation to GC-biased substitution, and phenotypic relevance
Publikováno v:
BMC Evolutionary Biology, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background Two gerbil species, sand rat (Psammomys obesus) and Mongolian jird (Meriones unguiculatus), can become obese and show signs of metabolic dysregulation when maintained on standard laboratory diets. The genetic basis of this phenoty
Externí odkaz:
https://doaj.org/article/8f2a04a7adf349ff9ec66e38aa6474a9
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-18 (2020)
Abstract Background Embryonic Sertoli cells (eSCs) have been known for playing important roles in male reproductive development system. In current studies, eSCs were mainly generated from induced intermediate mesoderm. The deriving mechanism of eSCs
Externí odkaz:
https://doaj.org/article/4d71a6f21805411ea97b8b2d9b00c758
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Placenta is an important organ that is crucial for both fetal and maternal health. Abnormalities of the placenta, such as during intrauterine growth restriction (IUGR) and pre-eclampsia (PE) are common, and an improved understanding of these diseases
Externí odkaz:
https://doaj.org/article/fb8d32571a294ffda952417bd3e9feeb
Publikováno v:
Vaccines, Vol 9, Iss 10, p 1128 (2021)
Porcine circovirus Type 2 (PCV2) is a primary etiological pathogen of post-weaning multi-systemic wasting syndrome (PMWS). The capsid protein of PCV2 is the crucial immunogenic protein which can induce antibody generation and immune responses. Howeve
Externí odkaz:
https://doaj.org/article/5c4fec4247304c4ca1f991ebf4d748bc
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Salinomycin, an important polyketide, has been widely utilized in agriculture to inhibit growth of pathogenic bacteria. In addition, salinomycin has great potential in treatment of cancer cells. Due to inherited characteristics and beneficial potenti
Externí odkaz:
https://doaj.org/article/204de2fba55141f2a8a8a4d55a94567f