Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Yiannis Koutalos"'
Autor:
Bill X Wu, Jie Fan, Nicholas P Boyer, Russell W Jenkins, Yiannis Koutalos, Yusuf A Hannun, Craig E Crosson
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133032 (2015)
Mutations of acid sphingomyelinase (ASMase) cause Niemann-Pick diseases type A and B, which are fatal inherited lipid lysosomal storage diseases, characterized with visceral organ abnormalities and neurodegeneration. However, the effects of suppressi
Externí odkaz:
https://doaj.org/article/c4368c7f3dce44b19e1a665ea1fb1f6b
Autor:
Jie Fan, Jian Liu, Jiali Liu, Peggi M. Angel, Richard R. Drake, Yan Wu, Hongkuan Fan, Yiannis Koutalos, Craig E. Crosson
Publikováno v:
Experimental eye research. 224
Sphingomyelinases (SMase), enzymes that catalyze the hydrolysis of sphingomyelin to ceramide, are important sensors for inflammatory cytokines and apoptotic signaling. Studies have provided evidence that increased SMase activity can contribute to ret
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 315:G713-G721
Loss of retinyl ester (RE)-rich lipid droplets (LDs) from hepatic stellate cells (HSCs) is cited as a key event in their cellular transdifferentiation to activated, pro-fibrotic myofibroblasts; however, it remains unclear if changes in LD morphology
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Bis-retinoids are a major component of lipofuscin that accumulates in the retinal pigment epithelium (RPE) in aging and age-related macular degeneration (AMD). Although bis-retinoids are known to originate from retinaldehydes required for the
Publikováno v:
Photochem Photobiol Sci
Retinal, the vitamin A aldehyde, is a potent photosensitizer that plays a major role in light-induced damage to vertebrate photoreceptors. 11-Cis retinal is the light-sensitive chromophore of rhodopsin, the photopigment of vertebrate rod photorecepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4dcc05e6654688d3c244d814068adf
https://europepmc.org/articles/PMC7559207/
https://europepmc.org/articles/PMC7559207/
Publikováno v:
Exp Eye Res
Ceramides are bioactive compounds that play important roles in regulating cellular responses to extracellular stimuli and stress. Previous studies have shown that ceramides contribute to retinal degeneration associated with ischemic and ocular hypert
Autor:
M. Wade Calcutt, Yiannis Koutalos, Zsolt Ablonczy, Richard M. Caprioli, Anne Hanneken, David M. Anderson, Rosalie K. Crouch, Kevin L. Schey, Jeffrey M. Spraggins
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
Stargardt disease is a juvenile onset retinal degeneration, associated with elevated levels of lipofuscin and its bis-retinoid components, such as N-retinylidene-N-retinylethanolamine (A2E). However, the pathogenesis of Stargardt is still poorly unde
Autor:
Yiannis Koutalos, Debra A. Thompson, Leopold Adler, Chunhe Chen, Federico Gonzalez-Fernandez, Patrice Goletz
Publikováno v:
Journal of Biological Chemistry. 292:19356-19365
Interphotoreceptor retinoid-binding protein (IRBP) is a specialized lipophilic carrier that binds the all-trans and 11-cis isomers of retinal and retinol, and this facilitates their transport between photoreceptors and cells in the retina. One of the
Autor:
John E. Donello, Rosalie K. Crouch, Patrick Pallitto, Yiannis Koutalos, Julia E Herrmann, E. Ellen Jones, Zsolt Ablonczy, Richard R. Drake
Publikováno v:
Photochemical & Photobiological Sciences. 14:1888-1895
The accumulation of lipofuscin, an autofluorescent aging marker, in the retinal pigment epithelium (RPE) has been implicated in the development of age-related macular degeneration (AMD). Lipofuscin contains several visual cycle byproducts, most notab
Autor:
Neel Dey, Christine A. Curcio, Yiannis Koutalos, Sungmin Hong, Thomas Ach, R. Theodore Smith, Guido Gerig
Publikováno v:
Med Image Anal
Autofluorescence is the emission of light by naturally occurring tissue components on the absorption of incident light. Autofluorescence within the eye is associated with several disorders, such as Age-related Macular Degeneration (AMD) which is a le