Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Yi-liang LIU"'
Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration
Autor:
Ju-Yi Hsieh, Kun-Chi Chen, Chun-Hsiung Wang, Guang-Yaw Liu, Jie-An Ye, Yu-Tung Chou, Yi-Chun Lin, Cheng-Jhe Lyu, Rui-Ying Chang, Yi-Liang Liu, Yen-Hsien Li, Mau-Rong Lee, Meng-Chiao Ho, Hui-Chih Hung
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract Human mitochondrial NAD(P)+-dependent malic enzyme (ME2) is well-known for its role in cell metabolism, which may be involved in cancer or epilepsy. We present potent ME2 inhibitors based on cyro-EM structures that target ME2 enzyme activity
Externí odkaz:
https://doaj.org/article/8c54706653c84fc5ab3e4d4963ea7c0e
Autor:
Yi-Fang Yang, Chuang-Ming Wang, I.-Hsin Hsiao, Yi-Liang Liu, Wen-Hao Lin, Chih-Li Lin, Hui-Chih Hung, Guang-Yaw Liu
Publikováno v:
Cellular & Molecular Biology Letters, Vol 27, Iss 1, Pp 1-25 (2022)
Abstract Peptididylarginine deiminase type 2 (PADI2) catalyzes the conversion of arginine residues to citrulline residues on proteins. We demonstrate that PADI2 induces T cell activation and investigate how PADI2 promotes activated T cell autonomous
Externí odkaz:
https://doaj.org/article/802dbea7a5d24e36b93b82939b615eb4
Autor:
Kristyn Hayashi, Kenton L. Longenecker, Yi-Liang Liu, Bryan Faust, Aditi Prashar, Johannes Hampl, Vincent Stoll, Sandro Vivona
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Melanotransferrin (MTf) is an iron-binding member of the transferrin superfamily that can be membrane-anchored or secreted in serum. On cells, it can mediate transferrin-independent iron uptake and promote proliferation. In serum, it is a tr
Externí odkaz:
https://doaj.org/article/e40faf28a7d64f9d868ff1e3a76c9fde
Publikováno v:
Symmetry, Vol 14, Iss 10, p 2102 (2022)
In this paper, we investigate a spherically symmetric inverse heat conduction problem, which determines the internal surface temperature distribution of the hollow sphere from measured data at the fixed location inside it. This problem is ill-posed,
Externí odkaz:
https://doaj.org/article/52644d8b68854108b1483ddee83fb9a6
Autor:
Ju-Yi Hsieh, Hao-Ping Yang, Sunil Kumar Tewary, Hui-Chen Cheng, Yi-Liang Liu, Shih-Chieh Tai, Wei-Lin Chen, Chien-Hui Hsu, Ting-Jhen Huang, Chuan-Jung Chou, Yu-Nan Huang, Ching-Tien Peng, Meng-Chiao Ho, Guang-Yaw Liu, Hui-Chih Hung
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102034- (2021)
Summary: Human mitochondrial NAD(P)+-dependent malic enzyme (ME2) is well recognized to associate with cancer cell metabolism, and the single nucleotide variants (SNVs) of ME2 may play a role in enzyme regulation. Here we reported that the SNVs of ME
Externí odkaz:
https://doaj.org/article/4346595fc4e4492a8c26e89d16339be5
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Our recent studies of peptidylarginine deiminase 4 (PAD4) demonstrate that its non-catalytic Ca2+-binding sites play a crucial role in the assembly of the correct geometry of the enzyme. Here, we examined the folding mechanism of PAD4 and th
Externí odkaz:
https://doaj.org/article/9aceff9d3ef9404389090cd44055a0a0
Publikováno v:
Tongxin xuebao, Vol 35, Pp 233-239 (2014)
Vehicle networking intrusion detection solutions (IDS) can be used to confirm the authenticity of the events described in the notice of traffic incidents.The current Vehicle networking IDS frequently use detection scheme based on the consistency of r
Externí odkaz:
https://doaj.org/article/b9a6e905492343f0867ba4c3eb9fe234
Autor:
Na Shang, Qian Li, Tzu-Ping Ko, Hsiu-Chien Chan, Jikun Li, Yingying Zheng, Chun-Hsiang Huang, Feifei Ren, Chun-Chi Chen, Zhen Zhu, Melina Galizzi, Zhu-Hong Li, Carlos A Rodrigues-Poveda, Dolores Gonzalez-Pacanowska, Phercyles Veiga-Santos, Tecia Maria Ulisses de Carvalho, Wanderley de Souza, Julio A Urbina, Andrew H-J Wang, Roberto Docampo, Kai Li, Yi-Liang Liu, Eric Oldfield, Rey-Ting Guo
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004114 (2014)
Trypanosomatid parasites are the causative agents of many neglected tropical diseases and there is currently considerable interest in targeting endogenous sterol biosynthesis in these organisms as a route to the development of novel anti-infective dr
Externí odkaz:
https://doaj.org/article/7aa1b1fa08484e2681faf43225862b98
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104865 (2014)
Ornithine decarboxylase (ODC) catalyzes the decarboxylation of ornithine to putrescine and is the rate-limiting enzyme in the polyamine biosynthesis pathway. ODC is a dimeric enzyme, and the active sites of this enzyme reside at the dimer interface.
Externí odkaz:
https://doaj.org/article/efe21826aec1404e8971f70db5061161
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e51660 (2013)
This study investigated the functional roles of the N-terminal Ca(2+) ion-binding sites, in terms of enzyme catalysis and stability, of peptidylarginine deiminase 4 (PAD4). Amino acid residues located in the N-terminal Ca(2+)-binding site of PAD4 wer
Externí odkaz:
https://doaj.org/article/faa4ba82d0104a499fbe41b6b5d99398