Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2

Autor: Rong-Hsuan Wang, Pin-Ru Chen, Yue-Ting Chen, Yi-Chang Chen, Yu-Hsin Chu, Chia-Chen Chien, Po-Chen Chien, Shao-Yun Lo, Zhong-Liang Wang, Min-Chen Tsou, Ssu-Yu Chen, Guang-Shen Chiu, Wen-Ling Chen, Yi-Hsuan Wu, Lily Hui-Ching Wang, Wen-Ching Wang, Shu-Yi Lin, Hsing-Jien Kung, Lu-Hai Wang, Hui-Chun Cheng, Kai-Ti Lin

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Most cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation to aerobic glycolysis for energy production. By reducing enzyme activity of pyruvate kinase M2 (PKM2), cancer cells attain a greater fraction of glyco

Externí odkaz: https://doaj.org/article/11ac430e3387400d8e564c205164f273

Segmental ureterectomy outcome of upper tract urothelial carcinoma in a high endemic area: A Taiwan nationwide collaborative study

Autor: Shih‑Gang Wang, Hao‑Lun Luo, Hung‑Jen Wang, Wen‑Jeng Wu, Wei‑Ming Li, Po‑Hung Lin, See‑Tong Pang, Shian‑Shiang Wang, Jian‑Ri Li, Han‑Yu Weng, Ta‑Yao Tai, Jen‑Shu Tseng, Wun‑Rong Lin, I‑Hsuan Alan Chen, Jen‑Tai Lin, Yuan‑Hong Jiang, Yu‑Khun Lee, Jen Kai Fang, Chao‑Yuan Huang, Wen‑Hsin Tseng, Wei Yu Lin, Chia‑Chang Wu, Shu‑Yu Wu, Pai‑Yu Cheng, Po‑Han Lin, Yung‑Tai Chen, Allen W. Chiu, Bing-Juin Chiang, Chao-Hsiang Chang, Chao-Yuan Huang, Cheng-Huang Shen, Cheng-Kuang Yang, Cheng-Ling Lee, Chen-Hsun Ho, Che-Wei Chang, Chia-Chang Wu, Chieh-Chun Liao, Chien-Hui Ou, Chih-Chen Hsu, Chih-Chin Yu, Chih-Hung Lin, Chih-Ming Lu, Chih-Yin Yeh, Ching-Chia Li, Chi-Ping Huang, Chi-Rei Yang, Chi-Wen Lo, Chuan-Shu Chen, Chung-Hsin Chen, Chung-You Tsai, Chung-Yu Lin, Chun-Hou Liao, Chun-Kai Hsu, Fang-Yu Ku, Hann-Chorng Kuo, Han-Yu Weng, Hao-Han Chang, Hong-Chiang Chang, Hsiao-Jen Chung, Hsin-Chih Yeh, Hsu-Che Huang, Ian-Seng Cheong, I-Hsuan Alan Chen, Jen-Kai Fang, Jen-Shu Tseng, Jen-Tai Lin, Jian-Hua Hong, Jih-Sheng Chen, Jungle Chi-Hsiang Wu, Kai-Jie Yu, Keng-Kok Tan, Kuan-Hsun Huang, Kun-Lin Hsieh, Lian-Ching Yu, Lun-Hsiang Yuan, Hao-Lun Luo, Marcelo Chen, Min-Hsin Yang, Pai-Yu Cheng, Po-Hung Lin, Richard Chen-Yu Wu, See-Tong Pang, Shin-Hong Chen, Shin-Mei Wong, Shiu-Dong Chung, Shi-Wei Huang, Shuo-Meng Wang, Shu-Yu Wu, Steven Kuan-Hua Huang, Ta-Yao Tai, Thomas Y. Hsueh, Ting-En Tai, Victor Chia-Hsiang Lin, Wei-Chieh Chen, Wei-Ming Li, Wei-Yu Lin, Wen-Hsin Tseng, Wen-Jeng Wu, Wun-Rong Lin, Yao-Chou Tsai, Yen-Chuan Ou, Yeong-Chin Jou, Yeong-Shiau Pu, Yi-Chia Lin, Yi-Hsuan Wu, Yi-Huei Chang, Yi-sheng Lin, Yi-Sheng Tai, Yu-Khun Lee, Yuan-Hong Jiang, Yu-Che Hsieh, Yu-Chi Chen, Yu-Ching Wen, Yung-Tai Chen, Zhe-Rui Yang

Publikováno v: Urological Science, Vol 35, Iss 1, Pp 42-50 (2024)

Purpose:. According to the National Comprehensive Cancer Network guidelines, segmental ureterectomy (SU) of upper tract urothelial carcinoma (UTUC) is a considerable option for selected mid- and distal ureteral urothelial carcinoma (UC). As a UTUC en

Externí odkaz: https://doaj.org/article/868ccc01ef6d43b89da2a5c22758bb61

Prevalence and Associated Factors with Frailty Using the Kihon Checklist among Community-Dwelling Older Adults in Taiwan

Autor: Chien-Chih Chen, Wei-Chien Hsu, Yi-Hsuan Wu, Fang-Yu Lai, Pei-Yu Yang, I-Ching Lin

Publikováno v: Medicina, Vol 60, Iss 8, p 1231 (2024)

Background and Objectives: Frailty in older adults is associated with adverse health outcomes. This study aimed to analyze the frailty status of community-dwelling older adults in Taiwan using the Kihon Checklist (KCL) and explore associations with d

Externí odkaz: https://doaj.org/article/f50817858de84aca9954fcc3d19b4535

The impact of secondhand smoke on the development of kidney stone disease is not inferior to that of smoking: a longitudinal cohort study

Autor: Yi-Hsuan Chen, Jia-In Lee, Jung-Tsung Shen, Yi-Hsuan Wu, Yao-Hsuan Tsao, Jhen-Hao Jhan, Hsun-Shuan Wang, Yung-Chin Lee, Shu-Pin Huang, Szu-Chia Chen, Jiun-Hung Geng

Publikováno v: BMC Public Health, Vol 23, Iss 1, Pp 1-7 (2023)

Abstract Background Tobacco use and secondhand smoke (SHS) are risk factors of kidney stone disease (KSD). The hypothesis is that tobacco produces chemicals that increase oxidative stress and vasopressin, which leads to decreased urine output, and co

Externí odkaz: https://doaj.org/article/1f8616a53e17443e9ae75509297de7c5

Effects of robotic priming of bilateral arm training, mirror therapy, and impairment-oriented training on sensorimotor and daily functions in patients with chronic stroke: study protocol of a single-blind, randomized controlled trial

Autor: Yi-chen Lee, Yi-chun Li, Keh-chung Lin, Grace Yao, Ya-ju Chang, Ya-yun Lee, Chien-ting Liu, Wan-ling Hsu, Yi-hsuan Wu, Ho-ta Chu, Ting-xuan Liu, Yi-ping Yeh, Chieh Chang

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-9 (2022)

Abstract Background Combining robotic therapy (RT) with task-oriented therapy is an emerging strategy to facilitate motor relearning in stroke rehabilitation. This study protocol will compare novel rehabilitation regimens that use bilateral RT as a p

Externí odkaz: https://doaj.org/article/a50f0ab0be1e4e16a427e0514662487e