Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yi-de He"'
Publikováno v:
Nucleic Acids Research
G-quadruplex is an essential element in gene transcription that serves as a promising drug target. Guanine-vacancy-bearing G-quadruplex (GVBQ) is a newly identified G-quadruplex that has distinct structural features from the canonical G-quadruplex. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5608f6e16b0b47b8e5785945ec591f
https://doi.org/10.1093/nar/gkab1154
https://doi.org/10.1093/nar/gkab1154
Autor:
Wei Zhou, Zhan-Fen Qin, Yuan-Yuan Li, Jin-Bo Li, Ya-li Shi, Miao-xin Dong, Xiang Li, Yong-Jun Zhang, Yi-De He
Publikováno v:
Aquatic Toxicology. 257:106431
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5dfc5c6961014735bf4fd73d0042809
https://doi.org/10.1016/j.aquatox.2023.106431
https://doi.org/10.1016/j.aquatox.2023.106431
Autor:
Ke-wei Zheng, Jia-Yuan Gong, Juan-Nan Chen, Yong Zhao, Yu-hua Hao, Cui-Jiao Wen, Zheng Tan, Yi-de He, Jia-yu Zhang
Publikováno v:
Nucleic Acids Research
G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated in essential physiological and pathological processes and serve as important drug targets. The genome-wide detection of G4s in living cells is important for exploring th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eabf6f1b382a45f28a80c24a12f3eb84
http://europepmc.org/articles/PMC7672459
http://europepmc.org/articles/PMC7672459
Publikováno v:
Chemical Communications. 56:6567-6570
A dual-functional peptide-PNA (peptide nucleic acid) conjugate consisting of a PNA G3-tract and an RHAU23 peptide is devised to target nucleic acids bearing three tandem guanine tracts (G-tracts). The PNA G3-tract joins the three G-tracts to form a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34aa99fd6c2a300af43a6b0140202dda
https://doi.org/10.1039/d0cc02102d
https://doi.org/10.1039/d0cc02102d
Autor:
Ting-ting Cai, Hui-ting Liang, Yi-de He, Jiaqi Wang, Qingyang Zhao, Cheng-lin Wang, Ke-wei Zheng
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ff5a11e0a8d257ea4449761d0132d07
https://doi.org/10.2139/ssrn.4124043
https://doi.org/10.2139/ssrn.4124043
Autor:
Juan-Nan Chen, Cui-Jiao Wen, Ming-Liang Tang, Jia-Yuan Gong, Zheng Tan, Rui-Fang Duan, Yu-hua Hao, Yi-de He, Jia-yu Zhang, Ke-wei Zheng, Su-Ping Ren, Qun Yu
Publikováno v:
Proc Natl Acad Sci U S A
G-quadruplexes (G4s) formed by guanine-rich nucleic acids play a role in essential biological processes such as transcription and replication. Besides the >1.5 million putative G-4–forming sequences (PQSs), the human genome features >640 million si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13956de9ba46cccb9e638a4a9f3e61f
https://doi.org/10.1073/pnas.2013230118
https://doi.org/10.1073/pnas.2013230118
Autor:
Xin-min Li, Zheng Tan, Yu-hua Hao, Yi-de He, Ke-wei Zheng, Jia-Yuan Gong, Yong Zhao, Cui-Jiao Wen
Publikováno v:
Journal of the American Chemical Society. 142(26)
Stabilization of G-quadruplexes (G4s) formed in guanine-rich (G-rich) nucleic acids by small-molecule ligands has been extensively explored as a therapeutic approach for diseases such as cancer. Finding ligands with sufficient affinity and specificit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236d9d2250ed9c7787be4d47a30d7e19
https://pubmed.ncbi.nlm.nih.gov/32491844
https://pubmed.ncbi.nlm.nih.gov/32491844
Autor:
Juan-Nan Chen, Jia-Yuan Gong, Ke-wei Zheng, Jia-yu Zhang, Zheng Tan, Cui-Jiao Wen, Yi-de He, Yu-hua Hao
G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated in essential physiological processes and serve as important drug targets. The genome-wide detection of G4s in living cells is important for exploring the biological role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0848c168678bb6b3f341f95dc81f08
https://doi.org/10.1101/2020.05.06.080622
https://doi.org/10.1101/2020.05.06.080622
Publikováno v:
Nucleic Acids Research
DNA supercoiling is an important regulator of gene activity. The transmission of transcription-generated supercoiling wave along a DNA helix provides a way for a gene being transcribed to communicate with and regulate its neighboring genes. Currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82ef308a0c586385d691f4c90c96406
https://doi.org/10.1093/nar/gky534
https://doi.org/10.1093/nar/gky534
Publikováno v:
ACS Chemical Biology. 12:2609-2618
Transcription induces formation of intramolecular G-quadruplex structures at the upstream region of a DNA duplex by an upward transmission of negative supercoiling through the DNA. Currently the regulation of such G-quadruplex formation remains uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed05274aca02ea6f3e822300d6b7dc5
https://doi.org/10.1021/acschembio.7b00435
https://doi.org/10.1021/acschembio.7b00435