Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Yi-Yin Ku"'
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f852ee29a9488942fba6fce73ac0eaf
https://doi.org/10.1158/1535-7163.c.6543327.v1
https://doi.org/10.1158/1535-7163.c.6543327.v1
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
1. Measured pKa values of ABBV-167 (Table S1. Ionization constants of ABBV-167) 2. Preparation of ABBV-167 on large scale (Scheme S1: Synopsis of GMP synthesis of ABBV-167) 3. Preparation of clinical ABBV-167 drug supply 4. Animal pharmacokinetics (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b82ad084c554229baf59a8bada6e495
https://doi.org/10.1158/1535-7163.22522290
https://doi.org/10.1158/1535-7163.22522290
Autor:
Kaid C. Harper, En-Xuan Zhang, Zhi-Qing Liu, Timothy Grieme, Timothy B. Towne, Daniel J. Mack, Jeremy Griffin, Song-Yuan Zheng, Ning-Ning Zhang, Srinivas Gangula, Jia-Long Yuan, Robert Miller, Ping-Zhong Huang, James Gage, Moiz Diwan, Yi-Yin Ku
Publikováno v:
Organic Process Research & Development. 26:404-412
Publikováno v:
Organic Process Research & Development. 26:994-1001
Autor:
Kaid C. Harper, Yi-Yin Ku, Srinivas Grangula, Jeremy Griffin, Jia-long Yuan, Ning-ning Zhang, James R. Gage, Timothy Towne, Ping-zhong Huang, Song-yuan Zheng, Daniel J. Mack, Moiz Diwan, En-xuan Zhang, Robert W. Miller, Zhi-qing Liu, Timothy A. Grieme
Despite the growth of photoredox methods in academia, application of photoredox at scale in the pharmaceutical and fine chemical industries has been slow. In this report, a photoredox trifluoromethylation of a thiophenol was modified from the origina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a56e0229b56d06c2c27415db437cd5
https://doi.org/10.33774/chemrxiv-2021-z3xm8-v2
https://doi.org/10.33774/chemrxiv-2021-z3xm8-v2
Autor:
Yu-Ming Pu, Yi-Yin Ku, Vincent S. Chan, Michael D. Wendt, Timothy A. Grieme, Alan Christesen, Mathew M. Mulhern
Publikováno v:
The Journal of Organic Chemistry. 84:4814-4829
The process development of a new synthetic route leading to an efficient and robust synthetic process for venetoclax (1: the active pharmaceutical ingredient (API) in Venclexta) is described. The redesigned synthesis features a Buchwald-Hartwig amina
Autor:
Darren C. Phillips, Gary J. Jenkins, Richard S. Hong, Chang H. Park, Richard A. Marks, Rohinton P. Edalji, Russell A. Judge, Geoff G. Z. Zhang, Nathaniel D. Catron, Jie Chen, Ahmed Salem, Ahmad Y. Sheikh, John C. Kalvass, Kaid C. Harper, Rajeev M. Menon, Kennan C. Marsh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Ahmed A. Suleiman, Yu-Ming Pu, Yi Shi, Keith M. Fournier, Zhi-Fu Tao, DeAnne Stolarik, Shuang Chen, Orlando F. Bueno, Xilu Wang, Jianguo Ji, Yi-Yin Ku, Andrew J. Souers, Joel D. Leverson, Russell C. Klix, Steven W. Elmore
Publikováno v:
Molecular cancer therapeutics. 20(6)
Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2
Publikováno v:
Organic Process Research & Development; 3/18/2022, Vol. 26 Issue 3, p994-1001, 8p
Autor:
Harper, Kaid C., En-Xuan Zhang, Zhi-Qing Liu, Grieme, Timothy, Towne, Timothy B., Mack, Daniel J., Griffin, Jeremy, Song-Yuan Zheng, Ning-Ning Zhang, Gangula, Srinivas, Jia-Long Yuan, Miller, Robert, Ping-Zhong Huang, Gage, James, Moiz Diwan, Yi-Yin Ku
Publikováno v:
Organic Process Research & Development; 2/18/2022, Vol. 26 Issue 2, p404-412, 9p
Autor:
Michael D. Wendt, Yi-Yin Ku
Publikováno v:
ACS Symposium Series ISBN: 9780841234321
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7875803015cbfbc2608b4a60b5aa689
https://doi.org/10.1021/bk-2019-1332.ch001
https://doi.org/10.1021/bk-2019-1332.ch001