Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Yi-Xue Li"'
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Hybrid capture-based next-generation sequencing of DNA has been widely applied in the detection of circulating tumor DNA (ctDNA). Various methods have been proposed for ctDNA detection, but low-allelic-fraction (AF) variants are s
Externí odkaz:
https://doaj.org/article/9109c4be1bb3421c87d1ed3a4b4c1449
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-9 (2019)
Abstract Background One of the key reasons for the high failure rate of new agents and low therapeutic benefit of approved treatments is the lack of preclinical models that mirror the biology of human tumors. At present, the optimal cancer model for
Externí odkaz:
https://doaj.org/article/8ed0d5470f1645a2b88ed81923401a27
Autor:
Sheng He, Bo Hu, Chao Li, Ping Lin, Wei-Guo Tang, Yun-Fan Sun, Fang-You-Min Feng, Wei Guo, Jia Li, Yang Xu, Qian-Lan Yao, Xin Zhang, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Yi-Xue Li, Hong Li, Xin-Rong Yang
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Liver cancer is the second leading cause of cancer-related deaths and characterized by heterogeneity and drug resistance. Patient-derived xenograft (PDX) models have been widely used in cancer research because they reproduce the c
Externí odkaz:
https://doaj.org/article/1ec6149bf5984fbbaf61757bbf35315a
Autor:
Hui-Chuan Sun, Lu Xie, Xin-Rong Yang, Wei Li, Jian Yu, Xiao-Dong Zhu, Yong Xia, Ti Zhang, Yang Xu, Bo Hu, Li-Ping Du, Ling-Yao Zeng, Jian Ouyang, Wei Zhang, Tian-Qiang Song, Qiang Li, Ying-Hong Shi, Jian Zhou, Shuang-Jian Qiu, Qian Liu, Yi-Xue Li, Zhao-You Tang, Yu Shyr, Feng Shen, Jia Fan
Publikováno v:
Chinese Medical Journal, Vol 130, Iss 22, Pp 2650-2660 (2017)
Background: For Chinese patients with hepatocellular carcinoma (HCC), surgical resection is the most important treatment to achieve long-term survival for patients with an early-stage tumor, and yet the prognosis after surgery is diverse. We aimed to
Externí odkaz:
https://doaj.org/article/ee49e02b78cb40b3853111cc0ae34bd9
Autor:
Jing Yang, Hui Yu, Bao-Hong Liu, Zhongming Zhao, Lei Liu, Liang-Xiao Ma, Yi-Xue Li, Yuan-Yuan Li
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79729 (2013)
Differential co-expression analysis (DCEA) has emerged in recent years as a novel, systematic investigation into gene expression data. While most DCEA studies or tools focus on the co-expression relationships among genes, some are developing a potent
Externí odkaz:
https://doaj.org/article/b2bf960731c744f299d34f02a204c541
Autor:
Lu-Lu Zheng, Yi-Xue Li, Juan Ding, Xiao-Kui Guo, Kai-Yan Feng, Ya-Jun Wang, Le-Le Hu, Yu-Dong Cai, Pei Hao, Kuo-Chen Chou
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42517 (2012)
Bacterial pathogens continue to threaten public health worldwide today. Identification of bacterial virulence factors can help to find novel drug/vaccine targets against pathogenicity. It can also help to reveal the mechanisms of the related diseases
Externí odkaz:
https://doaj.org/article/32f3339b8a80408e82ac0ccd21e0740f
Autor:
Ya-Jun Wang, Jing-Fang Wang, Jie Ping, Yao Yu, Ying Wang, Peng Lian, Xuan Li, Yi-Xue Li, Pei Hao
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44079 (2012)
Influenza virus, which spreads around the world in seasonal epidemics and leads to large numbers of deaths every year, has several ribonucleoproteins in the central core of the viral particle. These viral ribonucleoproteins can specifically bind the
Externí odkaz:
https://doaj.org/article/5513593b654140c095470666824544cd
Autor:
Tao Huang, Xiao-He Shi, Ping Wang, Zhisong He, Kai-Yan Feng, Lele Hu, Xiangyin Kong, Yi-Xue Li, Yu-Dong Cai, Kuo-Chen Chou
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10972 (2010)
The metabolic stability is a very important idiosyncracy of proteins that is related to their global flexibility, intramolecular fluctuations, various internal dynamic processes, as well as many marvelous biological functions. Determination of protei
Externí odkaz:
https://doaj.org/article/6c59599778ed4033b2c8aafbe1e8615e
Analyses of copy number variation of GK rat reveal new putative type 2 diabetes susceptibility loci.
Autor:
Zhi-Qiang Ye, Shen Niu, Yang Yu, Hui Yu, Bao-Hong Liu, Rong-Xia Li, Hua-Sheng Xiao, Rong Zeng, Yi-Xue Li, Jia-Rui Wu, Yuan-Yuan Li
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14077 (2010)
Large efforts have been taken to search for genes responsible for type 2 diabetes (T2D), but have resulted in only about 20 in humans due to its complexity and heterogeneity. The GK rat, a spontanous T2D model, offers us a superior opportunity to sea
Externí odkaz:
https://doaj.org/article/de2f08df41944090b4231706c5a1edb2
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12126 (2010)
BACKGROUND: The Saccharopolyspora erythraea genome sequence was released in 2007. In order to look at the gene regulations at whole transcriptome level, an expression microarray was specifically designed on the S. erythraea strain NRRL 2338 genome se
Externí odkaz:
https://doaj.org/article/ab31219e672c43949625502af78e4e2c